calling magic32,tia and joevette (damm hes banned)

[goose]

magic since your an academic and specialist on DNP,always admired your intelligent views,its final Im getting 4;6 dinitro,found a source with the help of a great guy.Would love to hear an extended notion on your thoughts on this please.




During 1933, Dodds and Robertson27b published three communications dealing with the clinical application of a related nitro-compound, 4:6 dinitro-ortho-cresol. This drug was claimed by these authors to be from three to five times more powerful than dinitrophenol, although its toxicity was no greater. They believed that dinitro-ortho-cresol was superior
for weight reduction, since equal effects could be secured with one-third the dosage,also half-life is half as short as DNP.

[goose]

For tai!!!!

http://www.foxnews.com/story/0,2933,279482,00.html

[marcus300]

I cant wait for magic's response

[taiboxa]

For tai!!!!

http://www.foxnews.com/story/0,2933,279482,00.html

LOL why the hell.. would i be at risk for OD'ing on Wintergreen cream LOL!!!

[goose]

LOL why the hell.. would i be at risk for OD'ing on Wintergreen cream LOL!!!

I thought you was gay

[taiboxa]

i didnt take adderall
here
http://www.who.int/ipcs/publications/ehc/en/ehc220.pdf
i dont know what it is
but its pdf so its neat! i like frogurt!

[Panzerfaust]

I thought you was gay

LMAO @ "This points to the dangers of OTC drugs"...wtf? Who goes around layering that ****ing shit on 24hrs a day besides this retard?

Anyway, i am also interested to hear about this new fat burner.

[MrNice]

Tai, I say you frontload 18.25g for your first day.

Thats a one year dosage at 50mg ed. You'll be 2% bf in no time

[taiboxa]

Tai, I say you frontload 18.25g for your first day.

Thats a one year dosage at 50mg ed. You'll be 2% bf in no time

well i was thinking bout running a tbl spoon a day lol so OK!

[goose]

well i was thinking bout running a tbl spoon a day lol so OK!

[Giants11]

I would shoot Conciliator a PM too, he's knows more about DNP than anyone I've ever seen.

[MrNice]

Conciliator was banned.

I have however posted a thread on this topic on the forum he frequents most often. I'll repost anything he says on the subject over here.

[goose]

I would shoot Conciliator a PM too, he's knows more about DNP than anyone I've ever seen.

MAny thanks.He is a member here? He posts?

[goose]

Woops great stuff.You are a nice guy.

[goose]

Im thinking 60mg....IGF 120.....T3 75......This combo could change the face of fat loss.1 pound per day easy with min sides (I hope)

[spywizard]

goose, what about muscle loss.. at 75mcg i lose muscle...

[goose]

goose, what about muscle loss.. at 75mcg i lose muscle...

I agree a little high but in doing this we can keep the dino at minimal levels,we got the IGF to help us,but I would include a mild AAS Im thinking furazabol with Tbol 50mg each.With myo.Run the dino for 20 days.Just ideas Im playing with.

[MrNice]

I've read that PDF Tai posted.

From what I can gather:

DNC may or may not be mutagenic, no one is sure. (mutagens damage DNA)

It is not carcinogenic (does not cause cancer)

when given to pregnant rats it is not teratogenic (does not cause birth defects)

In the initial studies during the 30s they dosed it at 3mg/kg of bodyweight. This resulted in sweating, lethargy and restlessness. Also found to be effective were dosages like .5-1mg/kg.

[goose]

The idea with this drug is to find out :

Is the fat loss ratio to sides effects better than DNP.On paper it looks a winner same toxic levels and shorter half-life.

[MrNice]

Yeah I know what u mean, i was just posting that so you know you're not gonna get cancer and have 3 legged babies after one dose

[taiboxa]

for my next go i was thinking
pgcl/tren/igf/T4 and a tbl spoon of DNoC

[Property of Steroid.com]

Conciliator was banned..

Since Concilator has never posted anything that hasn't been posted on a discussion forum before, it's not a great loss, and joevette scammed somebody for a bunch of DNP, so that's not much of a loss either.

[magic32]

POSITION:
As has been expressed and explained in multiple threads, making detailing here unnecessary, I am NOT a proponent of DNP use. Nark and I have sworn never to touch the stuff again, although I am planning to add my residuals to the pesticide that I sprinkle around the parameter of my home.

SOURCES:
Most of my information on the health effects of dinitrophenols comes from old studies of patients who were prescribed diet pills containing it prior to the ban, and illicit Kovorkianesque doctors who did so afterwards.

RELEVANT LEARNING:
That said, your question is about the efficacy of using 4,6. As you know there are six different dinitrophenols, and during weight loss marketing (early/mid 30’s) the only one deemed safe enough to MASS market was 2,4. The reason given, if I recall correctly, had to do with systems rerouting override. Let me present a little background before explaining this (and no I don’t still have the data, although I typically make a point to keep everything and will kick myself later):

Although it acts on levels similar to them, DNP operates in***endently of hormonal negative feedback loops. This peculiar distinction (non-participation) is also observed in its relation to the body’s monitoring systems which though hormonally controlled are locally measured. For example, the hypothalamus measures satiety by reports sent to it from remote sensors: the amount of chewing that occurs in the mouth; the volume swallowed as registered by the throat; and remaining capacity in the stomach.

Well DNP’s uncoupling properties are well known, but what is less known and was mentioned earlier are the other ways in which it affects the body. Anyone who has ever taken it can attest to the extreme heat sensation, caused on a cellular level by uncoupling oxidative phosphorylation, which increases the body's temperature and metabolic rate. Yet, every time a DNP user takes his/her temp it’s normal (for them), although there have been some who claim elevated readings this is simply not possible (and only/consistently heralds death), which is where the rerouting comes in. DNP does literally increase your temp due to the expulsion of additional heat, but this is never registered by the mercury because the respiratory system offsets the increase by overextending itself, permitting the temp to remain stable. Thus mitochondrial inefficiency, lowered thyroidal output and respiratory system participation complete the lethargy puzzle. The persistent dryness of the mouth is partly due to dehydration, but mostly to the excessive breathing exerted by an overtaxed respiratory system.

All that was basically given to say this, each of the other 5 types of dintrophenols seemed more greatly affect respiratory involvement making the body less able to cope, and making them better pest/herbicides than 2,4. So although they were not necessarily more toxic, they’re effects were more debilitating, which oddly enough is the desired characteristic here…LOL. Just as the salt additive reduces the harshness experienced by 2,4 the harshness of 4,6 should exceed that of 2,4, making it as concluded by Dodds and Robertson more potent.

CONCLUSION:
I know from other threads that you only run low grade doses in conjunction with IGF so I’d just say “proceed with caution”. Also, you've written that said doses afford you the luxury of cardio, well it should be shunned on 4,6.

Of course the same principles that make DNP valuable, namely its feedback system nonparticipation, also make it susceptible to rebound. I don’t know what your experiences have been, but since DNP doesn’t impact the homeostatic set-point, the body seeks to recoup DNP weight losses after discontinuation as homeostasis restores normalcy. This was indeed my experience, minus the ancillary synergy of gear and T3. However, some have proposed the seemingly counterintuitive, alternate theory of “semi-permanence” as illustrated in SV-1’s DNP discourse (http://forums.steroid.com/showthread...ight=dnp+sv-1), specifically post 01-25-2005, 12:54 AM. However, it should be noted that such theories are predicated upon low dose, long-term DNP studies typically between 250 – 320 days. These durations would logically permit homeostatic adjustments, in which the weight loses would be registered as valid, instead abnormal.

M.

[marcus300]

I was waiting for your response magic and i wasn't disappointed, you crack me up!!!

[Property of Steroid.com]

POSITION:
As has been expressed and explained in multiple threads, making detailing here unnecessary, I am NOT a proponent of DNP use. Nark and I have sworn never to touch the stuff again, although I am planning to add my residuals to the pesticide that I sprinkle around the parameter of my home.


M.

Would you be interested in PyroGenX? It's also a Mitochondrial Uncoupler, but shouldn't pose the same health problems...i can send you some research...

[magic32]

Would you be interested in PyroGenX? It's also a Mitochondrial Uncoupler, but shouldn't pose the same health problems...i can send you some research...

You?
Send?


Come on Anthony, I'm still waiting for the Hunting joke!

------

Though uninterested for myself, I'm always up for seeing valuable research. Try to attach the joke also.

M.

[Property of Steroid.com]

You?
Send?


Come on Anthony, I'm still waiting for the Hunting joke!

------

Though uninterested for myself, I'm always up for seeing valuable research. Try to attach the joke also.

M.

I C/P'ed the joke from some other forum, I'm sure...I don't even remember it! The source on the secure suppliers list has his own site and he runs "Make me laugh" for gear contests, where the best joke gets a bunch of free gear (not joking...he really does that).

Check that site out, I'm sure I stole it from there...I honestly don't know the hunting joke anymore..I think it had to do with an umbrella and a gun, though...and a chick...

[goose]

Been speaking to a buddy of mine...This is not worth the risk,,,,in fact we talking about long term sides effects of DNP,some disturbing real notions,good post magic.

[MrNice]

Been speaking to a buddy of mine...This is not worth the risk,,,,in fact we talking about long term sides effects of DNP,some disturbing real notions,good post magic.

Yeah was just gonna post, according to others on another forum...it isn't worth the risk.


What has your buddy been saying about DNP?

[goose]

Yeah was just gonna post, according to others on another forum...it isn't worth the risk.


What has your buddy been saying about DNP?

Its over for me....the whole lot.Get out before its late,its great as I have done it .He is a BB,the collective data he has got with his own personal trials and others repeat users is weakness of vision,its ironic as I don't and never had to wear glasses,however,I have noticed my eyes are not as they were.Its similar to the notion of clen,use it once its OK.Same with DNP,even a couple of times,its the repeat user that the percentage of long term damage will became increased and getting this long term side is possible,long term clen users are fuced.Its no problem for me,as my coach has been praying for this day!!

[MrNice]

Aight I'm not planning on using it any time soon anyway, I've never had the crazy results some have. 4-5lbs in a week etc isn't worth my vision, If I'd seen 30lbs in 2 weeks like some then maybe I'd be loath to give it up.

Don't wanna end up like this guy

[goose]

Please take this quiz:


http://members.tripod.com/~Prof_Anil.../POISO018.HTML

[goose]

Résumé / Abstract
The effects of dinoseb (DNBP), a known testicular toxicant in the
rat, on germ cells were investigated in Sertoli-germ cell co-
cultures. Two DNBP-related dinitrophenolic compounds, 4,6-dinitro-o-
cresol (DNOC) and 2, 4-dinitrophenol (DNP), were also examined, as
testicular toxicity of these compounds had not been elucidated.
Cultures were exposed to each compound ( 10[-7]-10[-4] M) for 24 h
and examined for the number and viability of detached cells and
morphologic alterations under a light microscope. DNBP
significantly increased the number of detached cells (10[-5] and
10[-4]M) and suppressed their viability (10[-6]-10[-4] M).
Morphologic observations revealed degenerative alterations in the
germ cells and Sertoli cells. Similar effects as observed after
DNBP exposure were evident at 10[-4] M DNOC and 10[-4] M DNP. These
results demonstrate that DNBP, DNOC, and DNP have in vitro toxicity
to these cell populations at high concentration, and suggest the
possibility that DNOC and DNP also cause testicular damage in
experimental animals and humans.


Horner, W.D. 1942. Dinitrophenol and its relation to formation of
cataract. Arch. Ophthamol. 27:1097-1121.
2,4-dinitrophenol (2,4-DNP) and 4,6-dinitro-o-cresol (4,6-DNOC)
have been used clinically as weight reduction aids. Oral
administration of 2-5 mg/kg/day 2,4-DNP or 0.35-1.5 mg/kg/day 4,6-
DNOC produced cataracts in 0.1-1.0% of treated patients. Although
data regarding the cataractogenic effects of 4,6- dinitro-o-
cyclohexylphenol (4,6-DOCP) in humans were not available, it is
expected that 4,6-DOCP administration would also result in cataract
formation, since it is structurally related to 2,4-DNP and 4,6-
DNOC. Because Spencer et al. (1948) showed that the lipid
solubility of 4,6-DOCP (1.84 g/100 g of oil) is more closely
related to the solubility of 2,4-DNP (1.67 g/100 g of oil) than 4,6-
DNOC (5.98 g/100 g of oil) and that 4,6-DOCP and 2,4-DNP were about
equally toxic on a weight basis (mg/kg/day) to rats in a subchronic
feeding study, it is appropriate to derive an RfD by analogy to 2,4-
DNP.

Spencer et al. (1948) showed that 2,4-DNP, 4,6-DNOC and 4,6-DOCP
had similar effects in rats, but that 4,6-DNOC was toxic at lower
doses than either of the other two compounds. Rats received between
0 and 0.10% 4,6-DNOC or 4,6-DOCP, or 0 and 0.20% 2,4-DNP, in the
diet for 6 months. For 4,6-DOCP, the dietary levels of 0, 0.02,
0.05 and 0.10% corresponded to daily intakes of 0, 5.4-20, 13.5-50
and 27-100 mg/kg for these groups, respectively, based on each
rat's weight and food consumption. At the lower two dietary
concentrations, growth rates were ***ressed 3-10%, relative to
control rates. At 0.10%, the growth rate was ***ressed 10-15% below
control rates, and slight cloudy swelling of the liver was
observed. These changes were comparable to the effects seen in
separate groups of rats given the same doses of 2,4-DNP. Spencer et
al. (1948) found no cataracts in rats given dietary 2,4-DNP or 4,6-
DOCP for 6 months. The subchronic dietary rat study by Spencer et
al. (1948) is not useful for the RfD derivation because
experimental animals are not adequate models for the induction of
cataracts in humans by low-level oral exposure to dinitrophenols,
and, therefore, an RfD based on the rat data may not be adequately
protective for humans. There are no data on teratogenic effects of
4,6-DOCP.

[MrNice]

Conciliator had this to say:

While DNP was being sold for weight loss in the US, DNOC was being sold in the UK. Like your quote explains, the British researchers Dodds and Robertson were proponents of DNOC. They debated with Cutting and Tainter over which was the safest compound. Ultimately, both caused cataracts and both were removed from the market. As far as safety goes, I haven't seen any evidence to make me think one is any safer or more dangerous than the other. Of the two, DNOC is the stronger uncoupler, mg for mg. This is confirmed by recent research looking at the uncoupling capacity. DNOC's 4-5x greater strength underscores the importance of accurate capping and dosing. Any error is multiplied by a factor of 4-5 when compared to DNP, so be damn careful.

[magic32]

Been speaking to a buddy of mine...This is not worth the risk,,,,in fact we talking about long term sides effects of DNP,some disturbing real notions,good post magic.

Yeah, each of the other 5 can be quite hazardous, but I wanted to let you draw your own conclusions rather than just take the poison from you...so to speak. You made the right decision.

----------------------------------------

Anthony,

Don't sweat it, I remembered most of the joke, but wanted the genuine article.

I'm working on a screenplay, a romantic comedy about Cupid and his misadventures with a friend on earth. When the protagonist goes for a check up, the camera scrolls from the waiting room through the walls of several examination rooms while we eavesdrop on the patients (alone, w/nurses, and w/docs). One of which is your little old man who excitedly reports the unexpected pregnancy, followed by the Dr's regaling of the hunting tale.

M.