AI Rebound EFfect

[reddragon4954]

Been doing some research and was wondering if someone could shed some light on this.

I have heard that AI's such as letro and armidex can cause an estrogen rebound effect, but Aromasin there will be no rebound effect?

Is this true, Aromasin has no rebound effect?

[LATS60]

Been doing some research and was wondering if someone could shed some light on this.

I have heard that AI's such as letro and armidex can cause an estrogen rebound effect, but Aromasin there will be no rebound effect?

Is this true, Aromasin has no rebound effect?

Yes it's true.
Both anastrozole and letrozole are type II nonsteroidal AIs, whereas exemestane has a steroidal structure and is classified as a type I AI, also known as an aromatase inactivator because it irreversibly binds with and permanently inactivates the enzyme.

[reddragon4954]

bump

[LATS60]

bump

Honest, i'm not telling lies mate.
That post is not my opinion, it's a pharmacological fact.

[reddragon4954]

so even if Im paranoid about gyno and running 50mg ED of aromasin, there will still be no rebound effect then?

[LATS60]

so even if Im paranoid about gyno and running 50mg ED of aromasin, there will still be no rebound effect then?

As aromasin lowers estrogen by around 85% then it's a pretty good AI to use on cycle for gyno. It's also a good AI for use in PCT because it makes the aromatase enzyme inactive, however there will come a point were there has to be some rebound, when and/or how much i cannot possibly say.
You would have to get into the molecular mechanisms of aromatase reaction.
This is an extremely complicated issue, aromasin has been shown to be very potent and specific, but the structural basis of drug recognition by aromatase has remained elusive because the three-dimensional structure of this enzyme hasn't been determined.
So even the molecular endochronologist don't yet know exactly how this works.
But after writing all that, gyno should not be an issue if you take the right precautions.

[jc95605]

use adex while on cycle and aromsin while in pct.