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Thread: Glucocorticoids for endurence!!

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    Glucocorticoids for endurence!!

    we all know Glucocorticoids are very spread drugs on the doping-world!!they are use on cycling,football,climbing,cross country skier,thriathlon,rugby etc..in cycling "cortizon" is a drug with a tradition with more then 40 decades!!and many cyclers have reported after they have finish they carrier that they have win different races because of that drug(long time before EPO has come in).there are several Glucocorticoids that athletes are using:hidrocortizon,prednison,prednisolon,methylpr ednisolone,betamethazone,dexamethazone etc..

    from my reasearch i know some good reasons why Glucocorticoids(GC) are good for endurence:

    1)GC increase gluconeogenesis,which will release glucose in the blood,made out of the glicogen from the liver...the released glucose into the bloodstream will work as an energy supplier,but also will hit pancreatic receptors which will detect abnormal high levels of sugar in the blood and they will release INSULIN..HMMMM....INSULIN-A GREAT HORMONE INDEED!!BUT FOR RECOVERY ONLY!!not as pre-work out!!INSULIN it is counter productive to ATP production.INSULIN it is the hormone that after a work out will stop producing ATP levels,because the body needs to regenerate....

    2)The metabolic effects of these compounds consolidate glycogen reserves in muscle tissue and accelerate lipolysis and glycolysis mechanisms induced by catecholamines and growth hormone;

    3)Stimulation of fat breakdown in adipose tissue: The fatty acids released by lipolysis are used for production of energy in tissues like muscle, and the released glycerol provide another substrate for gluconeogenesis;

    4)Inhibition of glucose uptake in muscle and adipose tissue: A mechanism to conserve glucose,which will be use later as a second for of energy;

    5)neurostimulatory effects at cerebral GC receptors could attenuate central impressions of fatigue, and anti-inflammatory and analgesic effects could inhibit sensations of muscle pain on effort as well as raising the fatigue threshold;

    6)They also increase users’ tolerance for pain and enable them to sustain efforts that would be unbearable under normal conditions;

    7)GCs inhibit the production of prostaglandins!!this has 2 major benefits:

    a)it will inhibit prostaglandines from the muscle cells which will allow muscle to contract forward and forward,because you know when you exercise your's body respond by releasing prostaglandines in every tissues,to the point you will almost can't move..not to mention to perform..this is what happenes when you have fever from exercise-it is from prostaglandines...you know that all the couch tell you to take an aspirin if you have fever & muscle cramps..and yes this is good because aspirin inhibit the production of PG,but remember that aspirin is a non-steroidal drug,much more weaker then GCs..so when you use GCs you will avoid any over-trained symptoms,and you will regenerate faster;

    b)it will inhibit also the prostaglandines from the lungs which will cause Bronchoconstriction,with consequent coughing, wheezing, and shortness of breath.We all know that Exercise induced bronchoconstriction,and that's way after long exercise you will feel that you can not breathe anymore.GCs inhibit this effect.this is how GCs will give more AIR to you;

    8)GCs blocks endogenous release of ACTH,so your's cortizol levels will be shut down by feed-back mechanism.Blood levels of ACTH,beta-endorphin, cortisol, and cortisol-binding globulin were lowered by GCs(Dexamethazone in this case) at rest and after exercise in one scientific study;

    9)They possess pronounced anti-inflammatory activity and cause alteration of connective tissue in response to injuries. The anti-inflammatory and connective tissue effects of glucocorticoids might mask injuries;

    10)it remove the lactic acid by converting the glucose via the Cori cycle in the liver(gluconeogenesis)

    unfortunely GCs have some effects which are counter-productive to endurence also:

    1)Glucocorticoid treatment is often linked to increased whole-body energy expenditure and hypermetabolism. Glucocorticoids affect mitochondrial energy production, notably in the liver, where they lead to mitochondrial uncoupling reducing the efficacy of oxidative phosphorylation.( a metabolic pathway that uses energy released by the oxidation of nutrients to produce adenosine triphosphate (ATP))

    2)Glucocorticoids seem to reduce the effect of erythropoietin on these cells, most likely due to anti-inflammatory effects (the reduction of prostaglandin formation, since prostaglandin E2 has a stimulatory effect on erythropoietin action;

    it seems that short-term administration of GCs(few days) before a competition has most of it's beneffits,and this 2 side-effects that i have mention don't have time to make serious problems!!
    Last edited by bogdan84uzy; 12-22-2009 at 02:36 AM.

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    Im pretty sure you have posted this exact same thing before...what happened to your last thread?

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    Interesting read.

    Thanks.

    Best

    T

  5. #5
    very very interesting thread bro!!i think nowhone in this forum have talk about glucorticoids for doping!i think this is extremly important for cyclist,marathon runners,fotbol players etc

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    Quote Originally Posted by peachfuzz View Post
    Im pretty sure you have posted this exact same thing before...what happened to your last thread?
    no..it wasn't the same thing!!other way i wouldn't post that my friend!!i have remove that indeed when i have seen that nowhone don't know something about GCs or they are not interested.

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    interesting

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    for me a very interesting thing it is somtimes the corelations between GH & GCs(on metabolic effects) and also the antagonism:human growth hormones increased muscle mass,increased bone density,improved immune system function,while GCs they do exact the opposite:decrease muscle mass(they are catabolic hormones),decrease bone density,decrease very hard immune system function..but in the same time they have the same effect on the metabolic functions:
    -Promotes gluconeogenesis in the liver;
    -Reduces liver uptake of glucose;
    -both of them are hiperglicemic hormones;
    also i would like to tell you 2opposite hormones:GH & INSULIN.one it raise the glicemic index(GH) the other one it lowers it.so you might thing because they have opposite effects,one of them will not be a good ergogenic drug..but guess what??if you use it both they are highly synergetic!!and also we know that GCs inhibit the production of GH!!so there are hormones very hard to understand,but we all know 1 thing!!EVEN IF THEY HAVE ANTAGONIST EFFECTS,AND THE DOCTORS SAID THAT THEY CAN'T HAVE ANY ERGOGENIC PROPERTIES,THE ATHLETES ARE STILL USING ALL OF THEM IN EXOTIC COCKTAILS AND THEY WORK LIKE A MAGIC & PERFECT FORMULA!!
    BUT LET ME TELL YOU 1 THING ABOUT DOCTORS!!THEY SAID THAT THEY DO SCIENTIFC STUDIES AND SHOW US THAT DEXAMETHASONE,CLENBUTEROL,TESTOSTERONE OR ANY OTHER DRUG DIDN'T HAVE ANY INFLUENCE ON TRAINING,AND THEY DIDN'T HAVE ANY EFFECT..YEAH?REALY??THEN IT SEEMS THAT THOSE DRUGS WILL NOT HAVE ANY EFFECT ALSO ON SICK INDIVIDUALS NO?IF THEY WORK VERY GOOD ON SICK INDIVIDUALS,WHY YOU THINK THAT THEY WILL NOT WORK ON HEALTH MALES NO?if EPO does it jobs extremly good on people that have anemia,then for what reasons on a male with normal hematocrit levels will not work? lol

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    just look at that link:
    http://en.wikipedia.org/wiki/List_of...ses_in_cycling
    and you will see how doping has evolved thru the years,and how many were caught with cortizon why you think?because it decrease peformance?of course not

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    Intense (high VO2 max) or prolonged physical exercise stimulate cortisol release in order to increase gluconeogenesis and maintain blood glucose.Proper nutrition and high-level conditioning can help stabilize cortisol release.Cortisol, a glucocorticoid, and adrenaline are the main hormones released by the body as a reaction to stress. They elevate blood pressure and prepare the body for a fight or flight response.so GCs produce energy even in extrem situations,when the body finish it's own energy,GCs release glucose from liver to fuel the body!!so GCs are the "last hope" for endurence,when the body can't take anymore,GCs makes you go forward and forward!!
    Compared to prednisolone, hydrocortisone is about 1/4 the strength for the anti-inflammatory effect, while dexamethasone is about 40 times as strong as hydrocortisone.so you just can imagine how power dexa it is!

  11. #11
    for bodybuilding i don't see any purpose,but for endurence i thing that GCs are great drugs!!and even for bodybuilding maybe he has a purpose also-on PCT!because DEXAMETHASONE reduce very much the cortisol levels in the body!!

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    Quote Originally Posted by bandogfighter View Post
    if EPO does it jobs extremly good on people that have anemia,then for what reasons on a male with normal hematocrit levels will not work? lol
    very true!!same thing for TESTOSTERONE studies..they have told that they have make studies,and the only weight-increase is because of the whater retention

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    Quote Originally Posted by bandogfighter View Post
    for bodybuilding i don't see any purpose,but for endurence i thing that GCs are great drugs!!and even for bodybuilding maybe he has a purpose also-on PCT!because DEXAMETHASONE reduce very much the cortisol levels in the body!!

    Bollocks to taking glucocorticoid's in PCT. Why would you want to take compounds that increase the chances of losing LBM? Whther they decrease cortisol or not.

    GC's will also inhibit the synthesis of IGF.

    They also inhibit DNA and collegen sythesis in bone cultures.

    There are other far more efficient ways of reducing cortisol during PCT.

    For endurance, yeah, maybe. For bodybuilder's, no chance.

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    Quote Originally Posted by Swifto View Post
    Bollocks to taking glucocorticoid's in PCT. Why would you want to take compounds that increase the chances of losing LBM? Whther they decrease cortisol or not.

    GC's will also inhibit the synthesis of IGF.

    They also inhibit DNA and collegen sythesis in bone cultures.

    There are other far more efficient ways of reducing cortisol during PCT.

    For endurance, yeah, maybe. For bodybuilder's, no chance.
    yes GCs complet inhibits endogenous GH(and IGF-1 of course) and about losing LBM GCs in the first instance they increase the weight,thru some water retention,but after because of the catabolic phase yes they decrease muscle mass,and increase catabolism which weakness the body.but this thing happends only at long trataments and high dose..but the way i have said to use GCs are just few days(2 it is enought) before a competition,and i have think also @ all sports that needs a lot of endurence.for bodybuilding yes i don't see any purpouse!but this is a forum for all the drugs that increase performance,and not only @ bodybuilding,because there are a lot of athletes also that visit this forum(track & fields,fighters,cyclists,fotbol players etc).

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    I actually found some studies supporting what you posted. i should have posted them...

  16. #16
    ok..then post them pls because this is a subject very very good which nowhone in this forum have talk i think before bogdan...

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    Quote Originally Posted by peachfuzz View Post
    I actually found some studies supporting what you posted. i should have posted them...
    yeah..you should post it my friend!!but i want to give you the best exemplas to understand why i think GCs ARE VERY GOOD FOR ENDURENCE!!

    DO YOU REMEMBER PARABOLAN? ASK SOMEWHONE ON THIS FORUM ABOUT USING PARABOLAN ON THE ATHLETIC FIELD AND THEY WILL ALL SAY:STAY AWAY FROM THIS DRUG IF YOU ARE AN ATHLETE!! IT WILL KILL YOUR'S STAMINA!!

    Many say that PARA kills your's stamina because it cause a raise in prostaglandines in the lungs,which cause bronchoconstriction,with consequent coughing, wheezing, and shortness of breath,the same thing like after long exercise when you will feel that you can not breathe anymore.

    THEN IF PARABOLAN MAKES BRONCHOCONSTRICTION AND THIS WAY IT KILL STAMINA,THEN GCs WHICH ARE BRONCHODILATATORS AND THEY ARE USED IN TREATMENT OF ASHTMA,TOGETHER WITH CLENBUTEROL,WILL OF COURSE GIVES YOU AN ERGOGENIC AID AND RAISE VERY MUCH YOUR'S ENDURENCE BY EXACTLY THE OPPOSITE EFFECT OF PARABOLAN!!

    IT DOESN'T MAKE SENSE??

  18. #18
    Quote Originally Posted by bogdan84uzy View Post
    yeah..you should post it my friend!!but i want to give you the best exemplas to understand why i think GCs ARE VERY GOOD FOR ENDURENCE!!

    DO YOU REMEMBER PARABOLAN? ASK SOMEWHONE ON THIS FORUM ABOUT USING PARABOLAN ON THE ATHLETIC FIELD AND THEY WILL ALL SAY:STAY AWAY FROM THIS DRUG IF YOU ARE AN ATHLETE!! IT WILL KILL YOUR'S STAMINA!!

    Many say that PARA kills your's stamina because it cause a raise in prostaglandines in the lungs,which cause bronchoconstriction,with consequent coughing, wheezing, and shortness of breath,the same thing like after long exercise when you will feel that you can not breathe anymore.

    THEN IF PARABOLAN MAKES BRONCHOCONSTRICTION AND THIS WAY IT KILL STAMINA,THEN GCs WHICH ARE BRONCHODILATATORS AND THEY ARE USED IN TREATMENT OF ASHTMA,TOGETHER WITH CLENBUTEROL,WILL OF COURSE GIVES YOU AN ERGOGENIC AID AND RAISE VERY MUCH YOUR'S ENDURENCE BY EXACTLY THE OPPOSITE EFFECT OF PARABOLAN!!

    IT DOESN'T MAKE SENSE??
    HELL YEAH!!it makes a lot of sense!!all those words makes sense to me!and i think this is the best and also the easiest explanation on how GCs works for endurence

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    i want to make a remark about a relations between GCs & some steroids!!

    we all know that DIANABOL inhibits 50-70% of cortisol levels in the body,and we know that a lot of it's power comes also from that proportie!!

    another drug that has a strong anti-glucorticoid propertie is HALOTESTIN!!we know that HALO it is wide-spread used by endurence athletes because it's proportie of raising red blood cell mass!!and HALO does that because of it's anti-glucorticoid propertie,because like i have said before GCs inhibits prostaglandin E2,which has a stimulatory effect on erythropoietin action!!

    the 3rd drug i want to mention it is different!!and i want to talk about THG a.k.a. "THE CLEAR"!!Unlike most other anabolic steroids, THG also binds with high affinity to the glucocorticoid receptor!!..WOW!!we know that THG it is a designer steroid no?developed by Patrick Arnold especialy for athletes!!so this affinity to the glucocorticoid receptor,i don't think that was by chance or accidental no?i think it was specialy made this alteration for the athletes is an additive propertie!!and i know that a lot of endurence athletes were caught with it-Marion Jones, Dwain Chambers,Barry Bonds etc .so this must have a conection between GCs properties and endurence my opinion!!

  20. #20
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    and here is something about GCs & glycogen(the body’s energy storing
    molecule):

    -GCs they increase gluconeogenesis in the liver by the conversion of a few amino acids in cellular protein to glucose(Mobilization of amino acids from extrahepatic tissues: These serve as substrates for gluconeogenesis);

    -GCs increase hepatic storage of glucose;

    -GCs decrease the blood corpuscle utilization of glucose;

    All those things result in an inhibition of glucose uptake in muscle and adipose tissue: A mechanism to conserve glucose,which will be use later as a second for of energy.the first form of energy comes from stimulation of fat breakdown in adipose tissue(a Metabolic effects made also by GCs)

    During power exercises such as sprinting, when the rate of demand for energy is high, lactate is produced faster than the ability of the tissues to remove it and lactate concentration begins to rise. This is a beneficial process since the regeneration of NAD+ ensures that energy production is maintained and exercise can continue. The increased lactate produced can be removed in a number of ways including:

    •oxidation to pyruvate by well-oxygenated muscle cells which is then directly used to fuel the citric acid cycle,
    •conversion to glucose via the Cori cycle in the liver through the process of gluconeogenesis.

    ..and this is exactly what GCs make!!

    SO!!..GCs removes lactic acid from muscle by inhibiting insulin, which in turn inhibit the levels of ATP. When ATP is abundant in the body, some is released in the blood,where it is achieving certain receptors of the pancreas,which It releases insulin, which inhibits ATP levels,to stop the high blood sugar due to release of liver glycogen and "say" to mitochondria to stop the production of ATP. INSULIN stop production of ATP, to allow the body for regeneration needed after long exercise .

    GCs are good for endurence because they inhibit insulin,which also inhibit glucose from the blood,and with very low glucose levels in the blood,you can't make any muscle contraction,because of the lack of ATP!!

    GCs make deposits of glicogen in the liver,much more then your's natural limits(2000 kcal).This is energy storing far beyond that your's body can store without GCs!!the glicogen from the liver will be used in the process of gluconeogenesis,to transform the molecules of ADP back to ATP.this is how GCs remove the lactic acid from muscle and they supplies the muscles with ATP faster and for a longer time then your's body can without GCs!!
    Glycogen in the liver will release sugar during a workout. The presence of these sugars causes the pancreas to release insulin. Therefore, glycogen is “stored energy.” Glycogen, a complex carb, provides energy after being broken down into sugars without the pancreas having to release a lot of insulin. There is no sugar rush with the release of glycogen because it is gradual (complex carbohydrates break down slower).a “sugar rush,” will make fatigue due to the role that insulin plays in sugar degradation!!


    SO BECAUSE OF THAT METABOLIC EFFECTS GCs INCREASE PERFORMACE BY REMOVING THE LACTIC ACID FROM MUSCLE,AND CREATE FUEL FOR THE BODY FROM Stimulation of fat breakdown in adipose tissue & from the deposits of glicogen in the liver!!

    this is only when we talk about metabolic effects but GCs posses also others properties like i have said before:

    -neurostimulatory effects at cerebral GC receptors could attenuate central impressions of fatigue, and anti-inflammatory and analgesic effects could inhibit sensations of muscle pain on effort as well as raising the fatigue threshold;
    -They also increase users’ tolerance for pain and enable them to sustain efforts that would be unbearable under normal conditions;
    -GCs inhibit the production of prostaglandins!!this has 2 major benefits,i have said them before and i would not repeat them because i don't want to bore somewhone!
    -They possess pronounced anti-inflammatory activity and cause alteration of connective tissue in response to injuries. The anti-inflammatory and connective tissue effects of glucocorticoids might mask injuries;

    i have try to do my best to explain what i know about those drugs and about how they could help an athlete!!

    best regards!!

  21. #21
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    Quote Originally Posted by bogdan84uzy View Post
    yeah..you should post it my friend!!but i want to give you the best exemplas to understand why i think GCs ARE VERY GOOD FOR ENDURENCE!!

    DO YOU REMEMBER PARABOLAN? ASK SOMEWHONE ON THIS FORUM ABOUT USING PARABOLAN ON THE ATHLETIC FIELD AND THEY WILL ALL SAY:STAY AWAY FROM THIS DRUG IF YOU ARE AN ATHLETE!! IT WILL KILL YOUR'S STAMINA!!

    Many say that PARA kills your's stamina because it cause a raise in prostaglandines in the lungs,which cause bronchoconstriction,with consequent coughing, wheezing, and shortness of breath,the same thing like after long exercise when you will feel that you can not breathe anymore.

    THEN IF PARABOLAN MAKES BRONCHOCONSTRICTION AND THIS WAY IT KILL STAMINA,THEN GCs WHICH ARE BRONCHODILATATORS AND THEY ARE USED IN TREATMENT OF ASHTMA,TOGETHER WITH CLENBUTEROL,WILL OF COURSE GIVES YOU AN ERGOGENIC AID AND RAISE VERY MUCH YOUR'S ENDURENCE BY EXACTLY THE OPPOSITE EFFECT OF PARABOLAN!!

    IT DOESN'T MAKE SENSE??
    Hazard? Is that you?
    Last edited by peachfuzz; 12-22-2009 at 01:14 PM.

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    Here is one but it was done using recreationally trained women, not athletes...

    http://www.springerlink.com/content/063q481071518751/

    Abstract The present study investigated whether short-term oral administration of glucocorticoid would modify performance and selected hormonal and metabolic parameters during submaximal exercise in healthy women. Nine recreational female athletes completed cycling trials at 70–75% VO2 max until exhaustion after either placebo (Pla, gelatin) or oral prednisone (Cor, Cortancyl, 50 mg per day for 1 week) treatment, according to a double-blind and randomized protocol. Blood samples were collected at rest; after 10, 20, and 30 min of exercise; at exhaustion; and after 10 and 20 min of passive recovery for adrenocorticotrophic hormone (ACTH), dehydroepiandrosterone (DHEA), prolactin (PRL), growth hormone (GH), insulin (Ins), blood glucose (Glu), and lactate (Lac) determination. Cycling time was significantly increased with short-term Cor intake (Cor: 66.4 ± 8.4 vs. Pla: 47.9 ± 6.7 min, P < 0.01). ACTH and DHEA remained completely blunted throughout the experiment with Cor versus Pla (P < 0.01), whereas GH and PRL were significantly decreased with Cor after, respectively, 20 and 30 min of exercise (P < 0.05). No significant difference in Ins or Glu values was found between the two treatments but Lac concentrations were significantly increased with Cor versus Pla between 10 and 30 min of exercise (P < 0.05). These data indicate that short-term glucocorticoid intake improved endurance performance in women, but further investigation is needed to determine whether these results are applicable to elite female athletes and, if so, current WADA legislation needs to be changed.

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    Quote Originally Posted by peachfuzz View Post
    Hazard? Is that you?
    i don't understand what you want to say here..and about that study,thanks!!but i have know it!!good to know anyway!!

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    i have found anouther experimental study very interesting:

    Taking Dex Can Improve High Altitude Exercise Capacity In Certain Climbers, Study Finds!!

    ScienceDaily (Aug. 13, 2009) — Taking dexamathasone prophlyactically may improve exercise capacity in some mountaineers, according to Swiss researchers. Dexamathasone, known popularly to climbers as "dex," has been used for years to treat altitude-related symptoms in mountaineers, but has never been tested for its ability to improve exercise capacity at high altitude.
    "We have known that both tadalafil and dexamethasone are good for preventing high altitude pulmonary edema (HAPE) and dex for treating symptoms of acute mountain sickness (AMS). But we did not know whether they could also improve exercise capacity at altitude by reducing pulmonary hypertension, one of the important factors in altitude- related exercise limitations," said lead authors Manuel Fischler, MD, of the University Hospital in Zurich, Switzerland, and Hans-Peter Brunner-La Rocca, of the University Hospital in Basel, Switzerland.

    The results were published in the August 15th issue of the American Journal of Respiratory and Critical Care Medicine, the journal of the American Thoracic Society.

    The researchers recruited 23 mountaineers with a history of HAPE and administered baseline cardiopulmonary exercise tests a low elevation (490 meters, or 1607 feet). Subjects were tested for oxygen uptake kinetics by pedaling a stationary bike at a constant rate for six minutes, and then for exercise capacity by pedaling at 50 percent of their predicted maximum workload for one minute, then increasing output by 25 percent each additional minute until exhaustion, usually after 8 to 12 minutes.

    "At low altitude, peak exercise performance of subjects was significantly above age- and gender-adjusted normal values, indicating superior fitness in these subjects," noted Dr. Fischler.

    All participants were randomized to take either tadalifil, dexamethasone or placebo, beginning the day before a cable-car ascent from Alagna, Italy, at 1,100 meters (3,609 feet), to 3,200 meters (10,499 feet). They then ascended on foot to Capanna Gnifetti at 3,650 meters (11,975 feet). After an overnight stay at Capanna Gnifetti, the climbers finally ascended to Capanna Regina Margherita at 4,559 meters (14,957 feet).

    A second round of cardiopulmonary exercise tests were performed 4-5 hours after arrival, and echocardiographic examinations were performed the next day.

    "Reduced oxygen content in the air is the major limiting factor at high altitude. Reduction in exercise capacity goes in parallel to the reduction in oxygen up to an altitude of approximately 4000 meters. At higher altitudes, there is an even further reduction in exercise capacity," said Dr. Fischler. "As expected, exercise capacity at high altitudes was diminished among all groups and key indictors of cardiopulmonary stress were elevated."

    Both tadalafil and dexamethasone subjects showed a smaller drop in oxygen saturation over the placebo group, indicating a better uptake of oxygen, and a measure of pulmonary artery pressure was significantly less for both tadalifil and dexamethasone groups over placebo.

    But dexamethasone did show certain advantages over tadalafil. Heart rate increased in all groups, but significantly less so in the dexamethasone group, suggesting less activation of the autonomous nervous system at high altitude. While AMS did not differ between groups on day one, it was significantly less among the dexamethasone group on day two. Finally, and perhaps most significantly, VO2max (a key measurement of how efficiently the body is able to use oxygen) was significantly higher in the dexamethasone group at high altitude compared to both placebo and tadalafil groups.

    "In this study, we found that the most important limiting factor [with respect to exercise capacity at high altitude] is primarily pulmonary hypertension— elevated blood pressure in the circulation of the lungs— which may further reduce the oxygen uptake, particularly during exercise. Our study indicates that for HAPE-susceptible climbers, taking dexamethasone improved exercise capacity, oxygen uptake kinetics and decreased the anaerobic threshold," said Dr. Fischler. "Overall, this means that those climbers who took dex felt better, were able to do more, and probably experienced fewer altitude-related discomforts than both other groups."

    Glucocorticosteroids such as dexamethasone probably increase exercise capacity through several different mechanisms. They lower pulmonary artery pressure by enhancing nitric oxide availability, as well as stimulating alveolar sodium and water clearance, which may improve oxygen diffusion. Furthermore, they have anti-inflammatory properties and may act on the mental state of those who take it, endowing them with increased willingness to exert themselves.

    "There is, however, a word of caution to be made regarding the use of glucocorticosteriods," said Dr. Fischler. "Although short-term tolerability is generally good, they have significant side effects. They reduce the inflammatory response to infections, the increase blood glucose and in the long term, they may lead to osteoporosis, reduce muscle mass and skin thickness, just to name the most important ones. Therefore, they should not be used without prescription by a medical doctor. Further studies need to be done to determine whether these results are generalizeable to non-HAPE-susceptible climbers, but our research strongly suggests that dex taken prophylactically can have a therapeutic effect in those who have experience HAPE in the past."

    ..those things support what i just have said and like i have said short-term use of GCs is the best way!!you get most of it's beneffits,with out serious side effects

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    i have forgot to write about PULMONARY HYPERTENSION about they talk:
    pulmonary hypertension (PH or PHT) is an increase in blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, together known as the lung vasculature, leading to shortness of breath, dizziness, fainting, and other symptoms, all of which are exacerbated by exertion. Pulmonary hypertension can be a severe disease with a markedly decreased exercise tolerance and heart failure..AND IT'S SEEMS THAT THOSE SYMPTOMS EASY GO AWAY WITH A POWERFULL GCs AS DEX

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    From the beginning, what I have taken from this is that it that even though there are metabolic benefits (i dream of a drug that can burn my fat/turn up my metabolism) but it also causes your body to eat what muscle you have, as it is catabolic. Anything with that word in it, instantly turns me off ..

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    ..yeah..very true!!but i have never talk about this drug as a fat-burner even this drug do that very good!!and acts something like catecholamines(clen,salbutamol etc).and remember!T3 doesn't burn fat like hell but you must be carefull to use some steroids to protect your's muscle??i think all of today's fat burner have this proportie-T3,clenbuterol efedrine,DNP,all they burn fat but also can eat some of your's muscle mass..the only exception i think is GH!!

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    i might be totally wrong here but shouldnt insulin be left with the diabetes patients......give me shit if ya wana.....

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    Quote Originally Posted by love2liftiron View Post
    i might be totally wrong here but shouldnt insulin be left with the diabetes patients......give me shit if ya wana.....
    YOU ARE OFF-TOPIC!!IF YOU DON'T KNOW WHAT PLACE HAVE INSULIN IN DOPING THEN YOU ARE FAR AWAY FROM ALL THAT DOPING MEANS!!GO AND VISIT THAT SECTION OF THE FORUM FOR THAT:
    http://forums.steroid.com/forumdisplay.php?f=75
    ..AND LEAVE THIS TOPIC CLEAN!!NO OFFENSE!!

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