Example..

I do X exercise 150lbs x 10 reps x 10 sets = 15,000lbs pushed

Or I do 100lbs x 19 reps x 8 sets = 15,200lbs pushed

Is there a fatigue factor from the extra reps in the 2nd example that must be accounted for?

Just trying to figure out what the equivalent is when I go from low rep to high rep.