Dumbass q - how do you put together a cycle?

[Sworder]

Your making a habit of being incorrect now aren't your Sworder.

Contribute instead Swifto! Lets hear about the DHT receptors

Yes, 99% of the things I know are due to Michael Scally MD and Bill Roberts, I will always give them credit for my knowledge base. I haven't written any book nor attended Steroid Pharmacology 101. So...?

I am often wrong in my interpretations of data or in my theories, which I don't mind at all!

The interesting thing about the DHT derivatives is their concentration in different skin regions. If you would measure the metabolic enzyme (3-a hydroxysteroid dehydrogenase) in different areas you might find some interesting data and, it could be an explanation to the steroid induced acne distribution. I will look into this further...

[Bonaparte]

Contribute instead Swifto! Lets hear about the DHT receptors

Yes, 99% of the things I know are due to Michael Scally MD and Bill Roberts, I will always give them credit for my knowledge base. I haven't written any book nor attended Steroid Pharmacology 101. So...?

I am often wrong in my interpretations of data or in my theories, which I don't mind at all!

The interesting thing about the DHT derivatives is their concentration in different skin regions. If you would measure the metabolic enzyme (3-a hydroxysteroid dehydrogenase) in different areas you might find some interesting data and, it could be an explanation to the steroid induced acne distribution. I will look into this further...

http://en.wikipedia.org/wiki/3-beta-HSD
http://www.ncbi.nlm.nih.gov/pubmed/2243100
From what I can find, 3-beta-HSD is mainly responsible for the conversion of all hormonal precursors into more active hormones in the adrenal glands.
What does this have to do with the actions or metabolism of DHT-analogues (5a-reduced steroids)?

[Sworder]

3 Alpha, not beta!

[Bonaparte]

3 Alpha, not beta!

Ohhhh, now I see what you're getting at!
This is the enzyme that deactivates DHT in skeletal muscle (where it is concentrated).
But here's the problem: that only affects DHT, not masteron and other DHT derivatives, which were modified specifically to avoid deactivation by 3-a hydroxysteroid dehydrogenase, so that they could remain active in skeletal muscle and thus have have an anabolic effect.

So no...that's not it either. They just cause acne (if highly androgenic), lipolysis, and reduce estrogen because they share some properties of DHT.

[Sworder]

I will have to present it more thoroughly later. Before that, can we agree that "AAS acne" has a certain distribution?

What do you mean by "androgenic"? Having a high affinity for the AR? Having a "strong" expression when bound in the ligand? <- This is unknown as is the duration of binding, actually I remember seeing a paper which showed expression duration in different ligands. Never saved it but I will try to find it again.

I know it may be a difficult question to accurately answer but I would like to see what your response is. Androgenic/anabolic ratios have been thrown out, not very applicable...