Aromasin doesn't work?

[MR10X]

The mean baseline levels of estradiol and testosterone were 24.5 ± 8.8 pg/ml and 581 ± 165 ng/dl, respectively. Maximal suppression of estradiol (62 ± 14%) was observed 12 h after a single 25-mg dose of exemestane. Estradiol remained suppressed by 58 ± 21% at 24 h and returned to baseline 3–6 d after treatment (Fig. 3⇓). At the time of maximal estradiol suppression, plasma testosterone levels were unchanged and thereafter tended to increase by 32% between 2–3 d; however, contrary to the significant increase in testosterone observed after 10-d daily dosing, this change did not achieve statistical significance after a single oral dose. Serum LH and FSH concentrations were measured up to 24 h at the same time intervals as the exemestane samples for the PK analysis. The mean baseline levels of LH and FSH were 4.8 ± 2.2 and 1.3 ± 0.7 mIU/ml, respectively. The percent change from baseline up to 24 h is reported in Fig. 4⇓. The LH levels initially decreased by 26% at 2 h; thereafter, there was a tendency for an increase to a maximum of 81% at 24 h. The levels of FSH were unchanged up to 12 h and increased by 49% at 24 h.

[MickeyKnox]

Enzymes work do or do they? Well ask yourself this question what is the primary substrate of any enzyme? Answer proteins. Now the next question. What is the probability the enzyme is denatured to some extent as it passes thru the stomach with a PH of a whopping TWO! Answer about 100%!

Ergo unless your enzymes are "enteric coated" the degree of bioavailability is very low, such that what little "enzymmatic activity" your supplement contributes to enhance absorption in someone with an intact GI tract approximates ZERO, excepting the production of expensive feces. But if it's your desire to dump a load of money then "believe what you want".

Do you really obtain you evidence from another persons posts? Have you spent any of these countless hours looking for citations which support yours/their assertions. Because I've heard this same nonsense previously on many forums yet NO ONE provides the research to support this BS! Simply put:
1) NO AI or SERM results in a rebound effect upon their discontinuation
2) There are NO differences HTPA recovery with either AI!
3) Lastly there is NO EVIDENCE a low estrogen level causes or is associated with depressed libido, PROVIDING the TT is not significantly decreased and/or the TT;E-2 ratio are not remarkably elevated.

Oddly that's exactly how "bro science" is propagated, someone with an unyielding commitment to a belief, of a particular act of omission or commission, that the evidence matters not!

Pharmacokinetics
Following oral administration , exemestane is rapidly absorbed. After maximum plasma concentration is reached, levels decline polyexponentially with a mean terminal half-life of about 24 hours. Exemestane is extensively distributed and is cleared from the systemic circulation primarily by metabolism. The pharmacokinetics of exemestane are dose proportional after single (10 to 200 mg) or repeated oral doses (0.5 to 50 mg). Following repeated daily doses of exemestane 25 mg, plasma concentrations of unchanged drug are similar to levels measured after a single dose.

Incorrect information here,seriously where did the 9hr half life come from? Dose it twice a day? LMAO


Gender: The pharmacokinetics of exemestane following administration of a single, 25-mg tablet to fasted healthy males (mean age 32 years) were similar to the pharmacokinetics of exemestane in fasted healthy postmenopausal women (mean age 55 years).

The mean baseline levels of estradiol and testosterone were 24.5 ± 8.8 pg/ml and 581 ± 165 ng/dl, respectively. Maximal suppression of estradiol (62 ± 14%) was observed 12 h after a single 25-mg dose of exemestane. Estradiol remained suppressed by 58 ± 21% at 24 h and returned to baseline 3–6 d after treatment (Fig. 3⇓). At the time of maximal estradiol suppression, plasma testosterone levels were unchanged and thereafter tended to increase by 32% between 2–3 d; however, contrary to the significant increase in testosterone observed after 10-d daily dosing, this change did not achieve statistical significance after a single oral dose. Serum LH and FSH concentrations were measured up to 24 h at the same time intervals as the exemestane samples for the PK analysis. The mean baseline levels of LH and FSH were 4.8 ± 2.2 and 1.3 ± 0.7 mIU/ml, respectively. The percent change from baseline up to 24 h is reported in Fig. 4⇓. The LH levels initially decreased by 26% at 2 h; thereafter, there was a tendency for an increase to a maximum of 81% at 24 h. The levels of FSH were unchanged up to 12 h and increased by 49% at 24 h.

Hey bud, are we gonna get to see a supporting link sometime today? Or do you not want us to read the entire study ourselves? Is this possible?

Or are you just going to put up cut and paste all morning?