Quote Originally Posted by Bonaparte View Post
The effects of selective calcium channel blockers are limited to cardiac and smooth muscle. They don't affect skeletal muscle.
I had to smile when I saw you answered this, because I was thinking about commenting on this as well, because it's a really clever question.

As I understand it, amlodipine (and most other dihydropyridine ca antagonists) act primarily on L type calcium channel blockers, which are the most common type of calcium channels in all muscle tissue, including skeletal.

But I have seen empirical studies that say the effect on skeletal muscles is extremely small. I wonder why that is? Do you know?

Also (speaking of side effects of these type of blood pressure meds) don't ca antagonists also inhibit some endocrine cells? I thought that they reduced testosterone levels. Does that effect those on TRT?