
Originally Posted by
RangerDanger830
An AI is an aromatase inhibitor. Think of aromatase, aka estrogen synthase, as a primary means to increase estrogen in your body as it biosynthesizes it primarily through converting androgens (which is what you are elevating in your body) into dirty nasty estrogens.
An inhibitor works via two diffierent mechanisms, actively or allosterically. In an active inhibition the AI (adex or whatever you use) binds to the aromatase's active site). In doing this is essentially, in layman's terms, blocks any androgens from binding to the aromatase since the binding sight is already being occupied, kind of like a parking spot. Since no androgens can bind to the aromatase enzyme, the enzyme cannot make estrogen, yay.
In an allosteric inhibition the inhibitor binds to the allosteric site, which is any sight but the active sight. In doing so the inhibitor essentially changes the active site's shape so nothing can bind to it either, therefore no androgen to estrogen reactions can occur via the enzyme.
This is why it is so important to take an AI while on a cycle because on cycle you are experiencing a large amount of androgen in your body which can equate to a larger amount of estrogen in your body. Estrogen can cause gyno obviously, without it women would not have breasts, among other things.
The Nolva now, is an antagonist of estrogen which focuses primarily on your breast tissue, which can prevent and treat gyno along with other SERMs. In order for you to get gyno there has to be a significant amount of estrogen binding to the receptors in your breast tissue. What Nolva and other SERMs do is they bind to your breast receptors in the same way estrogen does. The different here is that the SERMs like Nolva do not activate the receptors. Essentially they are just stealing the parking space without creating gyno.
Now that I have concluded my bio 101 lecture I will get to the point here. Taking a reasonable dose of Nolva daily, 20mg per se, will help you prevent the onset of gyno if that is indeed what you have. So yes, take some until you get your AI. Now in doing this your estrogen in your body will not bind with your breast tissue and give you gyno. But you will still have high estrogen which means the other sides effects of having high estrogen will still be present.