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Originally Posted by
Mr.BB
You need to understand how the hormone gets release from the ester... Ok, maybe first you need to understand what is a esterified hormone.
An hormone attached to an ester its not active, and the bigger the ester the less water soluble it is. What is called ester is just a kind of "tail" of carbon atoms attached, the longer the ester the more carbons has all attached. For example proprianate ester is a 3 carbons chained together, undecanoate has an 11 carbon atoms chain.
Like I said before the bigger the carbon chain the lower the water solubility forcing the hormone+ester to remain deposited at injection site.
The hormone gets released by the action of 2 enzymes that remove the carbon chain ester, atom by atom, so the bigger the chain the slower it gets released to the blood stream to become active.
So if you have a deposit you will have this 2 enzymes "attacking" the esters to release the hormone, if you have 2 deposits you will have a larger surface area where the enzymes can attack.
There are other variables involved, but I think this makes a pretty picture of what happens.
If you inject in 2 places (or more), you will basically have a higher release rate, but of course it will not last the period of time it has been studied to work.