Dumbass q - how do you put together a cycle?

[Sworder]

LOL, thread starter asked how to stack. Dont think she will have prostate issues.

We are awaiting response, Bonaparte covered it in #3!

Women have the Skene's gland instead of the prostate. I wonder if androgens exert the same effects on the Skene's glad as they do in the prostate? Good point t-dogg.

[t-dogg]

We are awaiting response, Bonaparte covered it in #3!

Women have the Skene's gland instead of the prostate. I wonder if androgens exert the same effects on the Skene's glad as they do in the prostate? Good point t-dogg.

I would like to learn more about how steroids, peptides effect women more though. Im not even sure this forum has a section for that.

[Sworder]

I would like to learn more about how steroids, peptides effect women more though. Im not even sure this forum has a section for that.

Yes, I agree. I wish there was a section for women. Considering how different their physiology is, they shouldn't take advice from men on how to cycle. To some extent, I guess they could, but women with experience should be the ones giving the advice in a specific sub-forum.

[Bonaparte]

3-alpha hydroxysteroid dehydrogenase is an enzyme that converts DHT ->5α-androstan-3α,17β-diol. I haven't actually checked if the other AAS that are considered DHT derivatives would be subject to this enzyme, given their similar structure I would assume they are!

Ok, so what's my point and what am I saying? I am saying that the distribution of the enzyme causes DHT derivative steroids to be more active in certain tissues such as the skin and prostate. Producing what you call "androgenic" effects. This is the reason to why acne is more prominent with certain steroids because they have different tissue distribution. I do not believe in the notion that all DHT derivative steroids are producing their effects because of their "anti-estrogenic properties" as you are calling it. They compete at the estrogen receptor, sure but I don't think this would cause the "androgenic effects" seen by DHT.

It is well known that 5AR enzymes are heavily under the skin, wouldn't it make sense that 3a HSD enzymes would be close by and that is what is causing these effects?


What do you think? Is this plausible? If not, why?

Keep in mind, it's just a theory! Mindful that there may be something to it and would be great if you could provide some substrate to eradicate it. Please and thank you.


Edit: "(DHT derivatives) were modified specifically to avoid deactivation by 3-a hydroxysteroid dehydrogenase" I didn't know that... Hmm, know what they do? If that's the case I guess I am wrong

You will find in any profile written by "experts" that masteron is just a DHT molecule with a methyl group at the 2 position, which makes it resistant to deactivation in skeletal muscle by 3α-HSD. This is why DHT and Proviron are useless for muscle building (the main benefit they exert is a strength increase through the CNS), but mast and many other DHT derivatives have decent anabolic effect.
And if you'll look at the nomenclature of any other derivative of DHT, you'll notice some modification at the 2nd carbon.


I included some information from a paper I found to be interesting and applicable to the topic.

Human Types 1 and 3 3α-Hydroxysteroid Dehydrogenases: Differential Lability and Tissue Distribution
http://jcem.endojournals.org/content/86/2/841.full
RNA expression analysis indicates that human type 1 3α-HSD is expressed exclusively in the liver, whereas type 3 is more widely expressed and is found in the liver, adrenal, testis, brain, prostate, and HaCaT keratinocytes.

Type 3 3α-HSD is more widely expressed than type 1 3α-HSD. This enzyme is found in many peripheral tissues that produce active steroids, such as the prostate, the skin, the adrenals, and the brain. It is, thus, likely that type 3 3α-HSD plays a role in the intracrine control of active hormone levels in these tissues, especially DHT in the prostate.

This hypothesis is in agreement with the hypothesis being presented here, that type 3 3α-HSD is unique to human and that its role is to control the intracellular level of active steroids in peripheral target tissues.

See bold. And no, I do not believe that DHT derivatives cause acne in certain areas, and certainly not for the reason you're proposing. That just has to do with where androgen receptors are located and which sebaceous glands are sensitive to their activation, IMO.

[Sworder]

Thanks for taking the time.

[AD]

See bold. And no, I do not believe that DHT derivatives cause acne in certain areas, and certainly not for the reason you're proposing. That just has to do with where androgen receptors are located and which sebaceous glands are sensitive to their activation, IMO.

boss, looks like you will ace your exams!

[Bonaparte]

boss, looks like you will ace your exams!

LOL. Unfortunately my exam involved boring shit like general tissue types and joints. But I still did well

But I may have to bite my tongue when we get to endocrinolgy, or I may draw too much attention to myself. Haha

[warmouth]

LOL. Unfortunately my exam involved boring shit like general tissue types and joints. But I still did well

But I may have to bite my tongue when we get to endocrinolgy, or I may draw too much attention to myself. Haha

No no. This is going to be hilarious when you get there. You are going to be able to dwarf everyone else, including your professors with your knowledge on the subject. It still puzzles me how and why you know so much on the subject. I wish you would write a book(or at least an article to share with us). You know how some people are born with the gift of say, playing football, or fishing(me)? You were born with the gift of AAS knowledge, rivaled by no one living. Mr. BigHead!

[Bonaparte]

No no. This is going to be hilarious when you get there. You are going to be able to dwarf everyone else, including your professors with your knowledge on the subject. It still puzzles me how and why you know so much on the subject. I wish you would write a book(or at least an article to share with us). You know how some people are born with the gift of say, playing football, or fishing(me)? You were born with the gift of AAS knowledge, rivaled by no one living. Mr. BigHead!

Well I wouldn't go that far...
But thanks. Lol
A deep-seated need for appreciation and recognition is largely what drives me, though I've just recently recognized and come to terms with it.

[KarsenH]

This thread is ****ing crazy. I don't even know what's going on right now.

[panntastic]

No no. This is going to be hilarious when you get there. You are going to be able to dwarf everyone else, including your professors with your knowledge on the subject. It still puzzles me how and why you know so much on the subject. I wish you would write a book(or at least an article to share with us). You know how some people are born with the gift of say, playing football, or fishing(me)? You were born with the gift of AAS knowledge, rivaled by no one living. Mr. BigHead!

I agree a article would be amazing
Maybe you could help rewrite some science into the steroid profiles to help people really learn.
A steroid bible by Bonaparte of you will

[Until_It_Sleeps]

I would like to learn more about how steroids, peptides effect women more though. Im not even sure this forum has a section for that.

I'll just have to be your lab rat for that one.

Re about me and my goals: my avatar is my latest show pic, so my goals are to look like that only bigger. I went in at 119 lbs and 9%, so maybe something like 125 lbs and 5-6% would give me the look I'm after?

Not so much concerned about virilization as I'm beyond help at this point. I think I've used nearly everything there is (except Gh and insulin).

I guess what I'm looking for is "Choose one drug from column A, one from column B and one from column C" but I doubt that exists. There are some things I know have worked well for me - test e, eq, tren, deca - so maybe I just need to stick with those. I know women don't need a test base, but I just feel awesome when I'm on it.

[Until_It_Sleeps]

Oh, and this board has a section for women, but...well, you know.

[t-dogg]

I'll just have to be your lab rat for that one.

Re about me and my goals: my avatar is my latest show pic, so my goals are to look like that only bigger. I went in at 119 lbs and 9%, so maybe something like 125 lbs and 5-6% would give me the look I'm after?

Not so much concerned about virilization as I'm beyond help at this point. I think I've used nearly everything there is (except Gh and insulin).

I guess what I'm looking for is "Choose one drug from column A, one from column B and one from column C" but I doubt that exists. There are some things I know have worked well for me - test e, eq, tren, deca - so maybe I just need to stick with those. I know women don't need a test base, but I just feel awesome when I'm on it.

Sweet, I have a lab rat lol. You can be Ms. Frankenstein!

[Until_It_Sleeps]

Seriously, I have inquired (enquired?) at teaching hospitals about the possibility of being a real lab rat, because no one knows much about women and steroids! Most women who use them just stick with anavar and don't use them to actually get freaky big. So I'd love to be part of a real research project on side effects, blood values, etc. but for now I'll settle with trying anything and everything and posting about it online.

So...what are peptides?

[t-dogg]

Ive only used a few "peptides". Gw501516, clen. Im debating for my next cycle running GHRP-6, Id rather just be on hgh though.