Hmb

[nsa]

I was reading some stuff on hmb, It has methylbuterate in its name, so im assuming its methylated. Does anyone know if this means it is methylated and thus toxic to the liver?

[nsa]

Bump...

[bigpump23]

HMB is crap, you have to take a high dosage of it to be effective, not worth it

[nsa]

All you have to do is take 3 grams aday to get results. And its scientifically proven to cause muscle mass gains, so i know its not crap. I just want to know if it stresses your liver. Anyone with proven knowledge on this forum please help me out.

[Psychotron]

TRADE NAMES
HMB Fuel Plus (Twinlab) and HMB Fuel Mega 750 (Twinlab).

DESCRIPTION
Beta-hydroxy-beta-methylbutyrate, abbreviated HMB, is found naturally in living matter as a metabolite of the essential amino acid L-leucine. There is preliminary evidence suggesting HMB may have anticatabolic, as well as immunomodulatory, properties. As a nutritional supplement, it is popular among athletes engaged in strenuous physical activity.

HMB is also known as hydroxymethylbutyrate, beta-hydroxyisovalerate and 3-hydroxyisovalerate.

ACTIONS AND PHARMACOLOGY
ACTIONS
HMB has putative anticatabolic and immunomodulatory activities.

MECHANISM OF ACTION
The mechanism of HMB's possible actions is unknown. There is, however, speculation. The branched-chain amino acids L-leucine, L-isoleucine and L-valine are known to be beneficial to catabolic patients (sepsis, trauma, burns, etc.) by improving hepatic protein synthesis and nitrogen economy. These amino acids make up about one-third of muscle protein. Of these amino acids, L-leucine has the highest oxidation rate. Further, L-leucine has been shown to stimulate protein synthesis in muscle, and decreases in leucine levels in skeletal muscle and in serum have been noted following exhaustive exercise. However, L-leucine supplementation has not been found to have a significant effect on athletic performance. It has been speculated that the L-leucine metabolite HMB may be responsible for the inhibitory effect of L-leucine on protein breakdown. How this may happen is unknown.

In pigs, HMB is produced from alpha-ketoisocaproate, a metabolite of L-leucine, via the enzyme alpha-ketoisocarproate dioxygenase, an enzyme that requires oxygen and iron for its activity. This pathway, located in the cytosol, may also exist in humans. L-leucine is also metabolized in mitochondria to produce HMB in the form of HMB-coenzyme A (HMB-CoA), rather than free HMB.

HMB has been found to induce chicken macrophage growth and enhance chicken macrophage function in culture. It has also been found to enhance both humoral and cellular immunity in young broilers. The mechanism of these immunomodulatory activities is unknown.

PHARMACOKINETICS
Little is reported on the pharmacokinetics of HMB in humans. Apparently, HMB is absorbed, and about 50% of an ingested dose is excreted unchanged in the urine. HMB may be metabolized to beta-hydroxy-beta-methylglutaryl-CoA, which is, in turn, metabolized to acetyl-CoA and acetoacetate.

INDICATIONS AND USAGE
It is claimed that HMB can increase lean muscle mass and exercise performance, but this is far from conclusively established. There is the suggestion in some preliminary research that HMB may have some immunomodulating effects.

RESEARCH SUMMARY
One study has reported that HMB-supplemented subjects (receiving 1.5 or 3 grams daily) lifted more weight compared with unsupplemented subjects. The researchers concluded that either dose of HMB "can partly prevent exercise-induced proteolysis and /or muscle damage and result in larger gains in muscle function associated with resistance training."

Because the subjects in the above-described study were initiating training, another group of researchers sought to determine whether HMB might have effects similar to those reported in the first study — but this time in trained athletes. This was a double-blind study in which 40 experienced resistance-trained athletes were randomized to receive 0, 3 or 6 grams of HMB daily for 28 days. No significant differences were noted in whole body anabolic /catabolic status, muscle and liver enzyme efflux, fat/bone-free mass, fat mass, percent body fat, or leg press one repetition maximums(1RM) strength. More research is needed.

Very preliminary research in some animal models suggests that HMB supplementation may improve several immunological functions that may result in decreased mortality in these animals.

CONTRAINDICATIONS, PRECAUTIONS, ADVERSE REACTIONS
CONTRAINDICATIONS
None known.

PRECAUTIONS
Pregnant women and nursing mothers should avoid supplemental HMB.

ADVERSE REACTIONS
None reported.

OVERDOSAGE
No reported overdosage.

DOSAGE AND ADMINISTRATION
Some athletes use 3 grams of HMB daily during periods of training.

HOW SUPPLIED
Capsules — 250 mg, 500 mg, 750 mg

Tablets

[nsa]

But is it toxic to the liver like methylated products?

[Psychotron]

From what i can tell, no. Just about everything is toxic, depends on what else you are throwing at your liver.