
Originally Posted by
Wavelover
Hey Bro, Viagra doesn't increase NO release. Viagra block enzym called PDE5.
PDE5 exists in the penis, it works to breakdown cGMP. cGMP caused blood vessel to dilate, dilatation caused blood fill in the corpus penis. Pressurized blood make the penis erected.
Nitric Oxide created by NANC nerve cell. When brain send a signal, NANC create NO.
The nitric oxide stimulates an enzyme called guanylate cyclase in nearby cells, and this enzyme starts producing a chemical called cyclic guanosine monophosphate (cGMP).