Seroquel after workout?

[quadsofsteel]

Hey Everybody!! this is my first thread and im unsure if i should take my seroquel (anitpsychotic medication) directly prior to exercise. I normally take 3 doses of seroquel daily and one of them is in the morning. those people who take this medication know that its basically impossible to workout and sedated from seroquel. Anyway, i usually hit the gym (in the afternoon) after/around my normal sedated times of day. Afternoon workouts are good but id like to do a morning session because its more convenient but the only problem is my medication time. Basically what im asking is, would seroquel interfier negatively with the "anabolic environment" of muscle postworkout?

Ive read in another thread that seroquel acts negatively on testosterone but ive found no evidence supporting this idea in my personal research. if anyone has any information or ideas please post.

[Panzerfaust]

I would ask a doctor such a question...I worked in Health Care for years and am aware of this drug but not within the realm of your question.

[scibble]

I will hazard to answer the question, given my background as an MD, with the usual disclaimer: any advice given should not substitute for the advice and recommendations of your personal physician and is for general informational purposes only, not meant as specific recommendation for any particular person---since I don't know you from Adam.

Generally, I'd preface by saying that medical "facts" are often presented as factual when in fact the level of evidence varies, and the complexity of the issues are usually oversimplified. For instance, many doctors or articles/books will state "x" has "y" effect on "z". Whenever you hear this you must consider the evidence for the claim: is it

(A) based upon theory which "makes sense" and therefore is accepted as fact. often such "evidence" is not born out in reality, but the facts are still accepted by unknowing practitioners as the hard truth.

(B) based upon molecular studies done in a test tube or pitri dish--nuf said.

(C) based upon some obscure research done on hamsters or other animals. in these cases the science cannot always be applied to humans, particularly at dosages or situations used in the research.

(D) based upon experiments done on a selective or small population. sometimes these outcomes are not generalizable to the extent that folklore suggests.

in other words, everyone has difference in response to various drugs; organs respond differently in different people; effects depend upon dosage of drugs; and some drugs may have real chemical alterations on hormones but not causing a signficant clinical effect. So the answers are complicated right from the beginning.

Now to cut to the chase: All antipsychotics reduce dopamine, which thereby reduce aggression and psychotic thinking and behavior. Since dopamine inhibits your pituitary from secreting Prolactin, the drug tends to jack up your Prolactin. High prolactin levels have been found to inhibit "gonadal function" in both men and women. I will not venture to say that I've gone into it far enough to explain by what mechanism it does this in men, but suffice it to say, it is written. I cannot vouch for the level of experiementation by which this was determined, which may be thin or broad, I just can't say without digging much deeper.

So it's quite possible. Whether YOUR dose of YOUR drug (seroquel) will do that to YOU and to the extent that if it did, would cause sufficient lowering of YOUR testosterone to cause diminished anabolic environment in YOU is anyone's guess. You might ask to have you testosterone, and possibly prolactin blood levels tested; I suppose that's what I would do. It probably does not impair the function of testosterone in the muscle cells, so this would not affect externally administered testosterone, only your own NAD-tural test.

Other ways in which seroquel could affect you gains: decreasing your insulin sensitivity--this is also different depending upon the individual. Further, by decreasing your aggression level, it could theoretically give you less "umph!!" or "drive" when you're lifting.

There are worse drugs than Seroquel in terms of these side effects, but it is one of the more sedating drugs, such that a lot of people are told that they are getting it to help them sleep. Discuss your goals with your doc and determine what measures might be attempted to help you live the life you want.

Adios dude.

[quadsofsteel]

wow scibble thanks for spending the time to write that long description. it helped alot!

[MercyDog]

I take one 600mg. dose at night and 3-100's of the day. As you already know it makes you eat like a horse. I mostly use it at night due to insomnia. When you use it to get a really good deep sleep it works WONDERS on recovery. Without taking it I can stay up for litterally weeks and get to the point where pain flows all through me from aching, not recovered muscles. There is nothing that will put me to bed like seroquel, I've tried everything, even thorazine. I went for years without dreams, now I have them back. Also it greatly helps with my homicidal tendancies when dealing with people during the day. hope this helps

[MercyDog]

btw every morning when I wake up I feel very, very, wired. To the point of feeling like I just had 10 cups of coffee. The drug isn't and doesn't have this affect on most all people but like I said I've got anxiety and tendencies pretty bad. I guess about 8 hours and its wearing off is why. Anyway I never work out doped on seroquel because it wouldn't be productive, although sometimes I feel like I'm ready to have a stroke. All and all I'd say getting the deep sleep at night makes it a plus and not a minus.

I think I actually suffer from a bad case of PTSD

[scibble]

will find this interesting:

Antipsychotic-induced Hyperprolactinemia Inhibits the HPG Axis and Reduces Bone Mineral Density in Male Patients With Schizophrenia:
Kishimoto,etal., Journal of Clinical Psychiatry, 69:3, March 2008

"It is believed GnRH in the hypothalamus is suppressed when the level of prolactin rises after administration of the antipsychotics, which then causes lowered secretion of LH and FSH in the pituitary and consequent lowered secretion of sex hormones such as estradiol and testosterone in the gonads, leading to abnormal bone metabolism similar to that associated with postmenopausal osteoporosis....

Prolactin-sparing antipsychotics include olanzapine, quetiapine, aripiprazole...prolactin-raising antipsychotics include first-generation antipsychotics and risperidone.

...results support the hypothesis of high prolactin level inhibiting the HPG axis, which has not been confirmed so far.

...the fact that estradiol was more markedly reduced than testosterone in the high prolactin group indicates that estrogens may have a major effect on bone metabolism in males."