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09-20-2009, 09:17 AM #1
Creatine Mono increases DHT and T:DHT ratio
1: Clin J Sport Med. 2009 Sep;19(5):399-404.
Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players.
van der Merwe J, Brooks NE, Myburgh KH.
Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.
OBJECTIVE: This study investigated resting concentrations of selected androgens after 3 weeks of creatine supplementation in male rugby players. It was hypothesized that the ratio of dihydrotestosterone (DHT, a biologically more active androgen) to testosterone (T) would change with creatine supplementation. DESIGN: Double-blind placebo-controlled crossover study with a 6-week washout period. SETTING: Rugby Institute in South Africa. PARTICIPANTS: College-aged rugby players (n = 20) volunteered for the study, which took place during the competitive season. INTERVENTIONS: Subjects loaded with creatine (25 g/day creatine with 25 g/day glucose) or placebo (50 g/day glucose) for 7 days followed by 14 days of maintenance (5 g/day creatine with 25 g/day glucose or 30 g/day glucose placebo). MAIN OUTCOME MEASURES: Serum T and DHT were measured and ratio calculated at baseline and after 7 days and 21 days of creatine supplementation (or placebo). Body composition measurements were taken at each time point. RESULTS: After 7 days of creatine loading, or a further 14 days of creatine maintenance dose, serum T levels did not change. However, levels of DHT increased by 56% after 7 days of creatine loading and remained 40% above baseline after 14 days maintenance (P < 0.001). The ratio of DHT:T also increased by 36% after 7 days creatine supplementation and remained elevated by 22% after the maintenance dose (P < 0.01). CONCLUSIONS: Creatine supplementation may, in part, act through an increased rate of conversion of T to DHT. Further investigation is warranted as a result of the high frequency of individuals using creatine supplementation and the long-term safety of alterations in circulating androgen composition. STATEMENT OF CLINICAL RELEVANCE: Although creatine is a widely used ergogenic aid, the mechanisms of action are incompletely understood, particularly in relation to dihydrotestosterone, and therefore the long-term clinical safety cannot be guaranteed.
PMID: 19741313 [PubMed - in process]
Raise in DHT and T: DHT ratio.
May explain why some get acne from Creatine Mono.
I'm actually still suffering from acne (6 weeks later) from an Epistane cycle lasting 3-4 weeks tappered off. I'm also taking 5-10g Creatine daily. I'll see if stopping Creatine Mono helps with the acne at all...
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09-20-2009, 09:31 AM #2
Interesting.
Could one say that it is indeed the increase in DHT that led to the "gains" derived from the creatine consumption?
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09-20-2009, 09:45 AM #3
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09-20-2009, 11:39 AM #4
interesting indeed. id like to know more details of the study tho.
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09-20-2009, 11:49 AM #5
I never knew that, interesting!
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09-20-2009, 12:55 PM #6
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09-20-2009, 12:57 PM #7
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09-20-2009, 01:24 PM #8
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