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05-08-2013, 12:30 AM #1
Ursodeoxycholic acid restores anabolic liver
Ursodeoxycholic acid restores anabolic liver
Mexican doctors managed to repair a bodybuilder's damaged using the bile acid ursodeoxycholic acid, UDCA for short. UDCA is a cholesterol regulator that humans manufacture in small quantities in the body. Doctors and supplements
manufacturers use a synthetic version of the substance. The full name for UDCA is 3alpha,7beta dihydroxy 5alpha cholan 24-oic acid.
The 29-year-old bodybuilder had been suffering from stomach pain for two months. Two weeks before he went to the doctor he also developed jaundice and itching. He had lost fourteen kilograms.
The doctors discovered that his liver was in a bad way. The steroids the bodybuilder had been taking had given him cholestasis, a condition in which the ducts in the liver become inflamed and therefore cannot remove bile to the duodenum. Bile removes cholesterol from the body.
Before becoming ill, the bodybuilder had taken a three-month course of 25 mg of proviron per day, 40 mg of andriol per day, 30 mg of deca per day, 50 mg of oxymetholone per day and 800 mg of testosterone per day. [It’s there in black and white – Ed.]
The doctors got the bodybuilder to stop taking the steroids and gave him a daily 15 mg per kg bodyweight of ursodeoxycholic acid. Ursodiol, as it is also called, removes poisonous bile acids and possibly also steroids from the liver by competition - and thus stimulates the recovery of the ducts through which the liver sends the bile acid to the duodenum in the gut. [Gut. 1991 Sep;32(9):1061-5.] It took a couple of months but the bodybuilder’s liver function recovered.
Alb = albumin; ALT = alanine aminotransferase; AP = alkaline phosphatase; AST = aspartate aminotransferase; DB = direct bilirubin; GGT = gamma-glutamyltransferase; PT = prothrombin time; TB = total bilirubin; TPT = partial thromboplastin time.
Sources: Liver Int. 2008 Feb;28(2):278-82.
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05-08-2013, 12:35 AM #2
Hepatology. 2002 Sep;36(3):525-31.
Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited.
Paumgartner G, Beuers U.
Department of Medicine II, Klinikum Grosshadern, University of Munich, Munich, Germany. [email protected]
Abstract
Ursodeoxycholic acid (UCDA) is increasingly used for the treatment of cholestatic liver diseases. Experimental evidence suggests three major mechanisms of action: (1) protection of cholangiocytes against cytotoxicity of hydrophobic bile acids, resulting from modulation of the composition of mixed phospholipid-rich micelles, reduction of bile acid cytotoxicity of bile and, possibly, decrease of the concentration of hydrophobic bile acids in the cholangiocytes; (2) stimulation of hepatobiliary secretion, putatively via Ca(2+)- and protein kinase C-alpha-dependent mechanisms and/or activation of p38(MAPK) and extracellular signal-regulated kinases (Erk) resulting in insertion of transporter molecules (e.g., bile salt export pump, BSEP, and conjugate export pump, MRP2) into the canalicular membrane of the hepatocyte and, possibly, activation of inserted carriers; (3) protection of hepatocytes against bile acid-induced apoptosis, involving inhibition of mitochondrial membrane permeability transition (MMPT), and possibly, stimulation of a survival pathway. In primary biliary cirrhosis, UDCA (13-15 mg/kg/d) improves serum liver chemistries, may delay disease progression to severe fibrosis or cirrhosis, and may prolong transplant-free survival. In primary sclerosing cholangitis, UDCA (13-20 mg/kg/d) improves serum liver chemistries and surrogate markers of prognosis, but effects on disease progression must be further evaluated. Anticholestatic effects of UDCA have also been reported in intrahepatic cholestasis of pregnancy, liver disease of cystic fibrosis, progressive familial intrahepatic cholestasis, and chronic graft-versus-host disease. Future efforts will focus on definition of additional clinical uses of UDCA, on optimized dosage regimens, as well as on further elucidation of mechanisms of action of UDCA at the molecular level.
PMID: 12198643 [PubMed - indexed for MEDLINE]
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05-15-2013, 12:09 PM #3
Thanks for the post and the update Turkish.
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05-15-2013, 01:37 PM #4
UDCA is some pretty amazing stuff good post!
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UDCA and NAC are my 2 top liver supps!
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05-16-2013, 11:35 AM #6
What is the difference between udca and tudca?
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05-23-2013, 09:07 PM #7
Udca is perscription
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05-24-2013, 12:03 AM #8~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~
"It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel
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05-24-2013, 10:49 AM #9
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05-24-2013, 10:50 AM #10~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~
"It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel
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05-24-2013, 11:15 AM #11
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