Austinite drops CoQ10 and picks up UBQH instead - Find out why!

[austinite]

Before we even start, let me explain what exactly CoQ10 is. Going into too much detail will only confuse you, I will try to keep the descriptions as simple as possible (not going to be easy but bear with me), because you have to understand its meaning and purpose so that you actually know what you're taking and what it does in your body.


What is Coenzyme Q10 (ubiquinone) – also known as Vitamin Q10 or CoQ10

Enzyme is proteins produced by the body.

The ‘Co’ refers to an organic nonprotein molecule that coexists to support the function of the protein above.

The ‘Q’ refers to Quinone; a class of compounds that aid in bone formation, blood clotting and more.

The ‘10’ refers to the 10 chemicals that make up the Quinone structure mentioned above.

CoQ10 is naturally synthesized by our bodies. It’s a key player in energy as it helps your ‘cellular power plants’ (Mitochondria) function. It aids it by supplying “Adenosine-5'-triphosphate” or ATP which is used as energy. It uses oxygen to generate energy from carbohydrates. This process is called ‘Oxidative Metabolism’.CoQ10 is a natural antioxidant, protecting your cells from reactive chemicals that can damage DNA. Your levels are a good indication of your overall antioxidant levels. Lower levels mean you're not very well protected.

Some crucial benefits include: preventative measure for cardiovascular disease & heart toxicity and a boost for your immune system. These benefits can prevent cancer, and CoQ10 has been used by medical professionals (in conjunction with other meds) as therapy for cancer patients. It’s been proven to aid in preventing cancer growth. Even heart transplant patients are given CoQ10. So you see, this is nothing to shake a stick at.

It’s abundant in your heart, pancreas, kidneys and liver, but it’s present in most tissue. However, as you age, your levels decline. Your body simply slows production down drastically. You want your CoQ10 levels to be in the upper range. Over 3.0 µg /mL. Quest Diagnostics range is 0.30-3.84, and not too many people over 30 years of age are in the upper range.

Now you understand how important CoQ10 is. It would be silly not to supplement with it. My endocrinologist recommended this for me during my first visit with her. After tons of research on the compound, I found that many endo’s recommend this. For good reason as we saw above.


If it’s so great, why switch to UBQH (ubiquinol)?

If you're a young fella in your 20’s or early 30’s, you probably produce enough CoQ10, so basic CoQ10 supplementation is plenty. However, as you get older, your ability to produce it diminishes, and the most important conversion to ubiquinol (where all the benefit comes from) is hindered tremendously. You simply can't metabolize CoQ10 sufficiently.

Furthermore; my research indicates that up to 40% of humans do not convert CoQ10 to the reduced form due to genetic make-up. That’s a lot of people! UBQH is a patented formula that contains an already converted compound. You're taking ubiquinol directly and your body utilizes it immediately.

When searching for it, you'll notice only one manufacturer makes UBQH. That’s Premier Science Integrative Therapeutics. If you see it from a different manufacturer, it’s NOT the real deal. This brand was the one that was studied and concluded all the benefits.

UBQH is actually absorbed up to 8 times higher than CoQ10 when taken orally. That’s a massive difference and you'll see it in your serum levels.


Scientific Research

When individuals have substandard plasma levels of (total) CoQ10 (<2.0 g/ml), CoQ10 supplementation frequently fails to provide an adequate therapeutic response, even at doses up to 900 mg/day.†18,19 Many individuals respond poorly, if at all. A study by Watson demonstrated a mean plasma CoQ10 level of only 1.7 g/ml in the treatment group with only two of 30 patients (ages 18-75 years old) having a level greater than 2.0 g/ml.18 The Khatta trial, which included fifty-five participants (mean age=64 years), demonstrated a mean plasma CoQ10 level of 2.2±1.2 g/ml, indicating that some patients on treatment had levels as low as 1.0 g/ml.19

A recent clinical study of seven adult men and women (ages 58-78) with low serum CoQ10 levels (mean level 1.4 g/ml) and corresponding left ventricular output decreases investigated their response to Kaneka QH supplementation.4 Follow-up data showed an increase in mean plasma CoQ10 levels from 1.6 mcg/ml to 6.5 mcg/ml, as well as an improvement in left ventricular function from 22% up to 39%.

In an experiment which used an animal model of aging, ubiquinol supplementation was associated with healthier aging (as determined by skin, eye, skeletal and general health) in comparison to aging in both the CoQ10 and control group.†20 The control group in this experiment experienced double the senescence scores in mid-life when compared to the ubiquinol group, while the CoQ10 supplemented group had senescence scores approximately 1.5 times as high as the ubiquinol group.† Increased senescence scores are an indication of the signs of aging.

Hormonal Influence on Coenzyme Q10 Levels in Blood Plasma:

Abstract:
Coenzyme Q10 (CoQ10), also known as ubiquinone for its presence in all body cells, is an essential part of the cell energy-producing system. However, it is also a powerful lipophilic antioxidant protecting lipoproteins and cell membranes. Due to these two actions, CoQ10 is commonly used in clinical practice in chronic heart failure, male infertility, and neurodegenerative disease. However, it is also taken as an anti-aging substance by healthy people aiming for long-term neuroprotection and by sportsmen to improve endurance. Many hormones are known to be involved in body energy regulation, in terms of production, consumption and dissipation, and their influence on CoQ10 body content or blood values may represent an important pathophysiological mechanism. We summarize the main findings of the literature about the link between hormonal systems and circulating CoQ10 levels. In particular the role of thyroid hormones, directly involved in the regulation of energy homeostasis, is discussed. There is also a link with gonadal and adrenal hormones, partially due to the common biosynthetic pathway with CoQ10, but also to the increased oxidative stress found in hypogonadism and hypoadrenalism.

Conclusions:
Antioxidant systems represent a key defense mechanism in our body and an unbalance of these systems can underly a wide spectrum of human disease. The reported experimental data show that systemic hormones can affect their levels, both in physiological and pathological conditions. However CoQ10 can be affected by different mechanisms; its low levels in plasma, in fact, can be due to accelerated metabolism and/or consumption, such as in hyperthyroidism and acromegaly, or a reduced synthesis, such as in hypoadrenalism and hypogonadism.

All pituitary hormones and the dependent glands (thyroid, adrenal, gonads) are involved, even if an unequivocal picture is far from being designed. However, it seems clear that in all the considered conditions, the effect of thyroid hormones is predominant on other hormones in influencing CoQ10 plasma levels. Even though more controlled studies are needed, the clinical usefulness of CoQ10 determination for a diagnosis refinement, or CoQ10 oral supplementation as a support to the specific endocrine therapy, has already been demonstrated in many cases.

> The source for the abstract above is an incredible read: Click here to view.


Let’s sum up some benefits of UBQH and its anti-aging effects :

1. Direct benefit as no conversion is needed by the body.
2. Highly absorbable/most bioavailable form.
3. Has the serum impact of up to 162% more than CoQ10.
4. Increased left ventricle function.
5. Better Blood flow.
6. Powerful Antioxidant.
7. Boosts your immune system.
8. Increases sperm count.
9. Aids in treatment of Gum disease.
10. Protects stomach lining.
11. Lowers blood pressure.
12. Protects Vitamin E. (finally something to protect E since it protects everything else!)
13. Aids in sugar stabilization.
14. Provides liver and kidney support.
15. Keeps a healthy heart: clogged arteries, angina, arrhythmia, etc…


How to dose UBQH:

As I mentioned I recommend this for folks over 30 years of age and especially for folks over 40.

100mg of UBQH once daily. Take with dietary fats. (adjust if needed after testing levels, no more than 600mg daily)

I recommend that you have your levels checked next time you get blood work, and evaluate from there should you need to adjust your dose. You only need Coenzyme Q10, Total.

Stay powerful.

[basketballfan22]

You mentioned that one should only purchase UBQH from Integrative Therapeutics. If UBQH is just ubiquinol which is a reduced and more bioavailable form of CoQ10, why shouldn't one purchase ubiquinol from other trustworthy companies, e.g. NOW Foods? Why is it too difficult for other companies to manufacture ubiqunol?

Great and very informative post by the way.

[austinite]

You mentioned that one should only purchase UBQH from Integrative Therapeutics. If UBQH is just ubiquinol which is a reduced and more bioavailable form of CoQ10, why shouldn't one purchase ubiquinol from other trustworthy companies, e.g. NOW Foods? Why is it too difficult for other companies to manufacture ubiqunol?

Great and very informative post by the way.

It's not stable outside the body. No one has managed to stabilize it but IT.

[austinite]

Stability and Safety

The safety, absorption, and bioavailability of ubiquinol have been established. Acute toxicity and safety studies of ubiquinol including genotoxicity tests, Ames, chromosome, and micronucleus tests have all been negative.20

In a recent placebo-controlled safety trial, single doses of Kaneka QH were given to 15 healthy volunteers (5 males and 5 females for the 150mg dose and 5 males for the 300mg dose).21 No safety concerns were noted, no changes in standard laboratory tests were observed, and no adverse events were reported in doses of up to 300mg for up to two weeks after the study's completion. In the bioavailability arm of the study, 78 healthy volunteers (10 males and 8 females each for placebo, 90 mg, 150mg, and 300 mg dose groups) received Kaneka QH for 4-weeks. No clinically relevant changes induced by Kaneka QH were noted in the subjects' standard laboratory tests, physical examination, vital signs, or electrocardiograph (ECG) readings in any dosage group.

Conclusion

Kaneka QH in UBQH is the same form of CoQ10 that is present in over 90 percent of the human bloodstream.16 UBQH would be appropriate for older adults, individuals presenting with NQ01 genetic inefficiencies, or those requiring higher doses of CoQ10 due to conditions that are associated with reduced blood CoQ10 levels.† Requiring no conversion from ubiquinone to ubiquinol, UBQH is ready to support nervous system and cardiovascular health in these populations.†

REFERENCE: Hosoe K, Kitano M, Kishida H, Kubo H, Fujii K, Kitahara M. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol 2007;47:19-28.

[basketballfan22]

It's not stable outside the body. No one has managed to stabilize it but IT.

So the ubiquinol one would purchase from other companies is unstable? Does this mean the compound will not be absorbed? You are one of the most vocal supporters of NOW Foods, so does this mean this is one compound you shouldn't trust NOW Foods with?

[Java Man]

Scholar. I'm going to check this out. My monthly natty supplement bill has gone up significantly since I joined here, I'll have you know Mr.!

[basketballfan22]

Stability and Safety

The safety, absorption, and bioavailability of ubiquinol have been established. Acute toxicity and safety studies of ubiquinol including genotoxicity tests, Ames, chromosome, and micronucleus tests have all been negative.20

In a recent placebo-controlled safety trial, single doses of Kaneka QH were given to 15 healthy volunteers (5 males and 5 females for the 150mg dose and 5 males for the 300mg dose).21 No safety concerns were noted, no changes in standard laboratory tests were observed, and no adverse events were reported in doses of up to 300mg for up to two weeks after the study's completion. In the bioavailability arm of the study, 78 healthy volunteers (10 males and 8 females each for placebo, 90 mg, 150mg, and 300 mg dose groups) received Kaneka QH for 4-weeks. No clinically relevant changes induced by Kaneka QH were noted in the subjects' standard laboratory tests, physical examination, vital signs, or electrocardiograph (ECG) readings in any dosage group.

Conclusion

Kaneka QH in UBQH is the same form of CoQ10 that is present in over 90 percent of the human bloodstream.16 UBQH would be appropriate for older adults, individuals presenting with NQ01 genetic inefficiencies, or those requiring higher doses of CoQ10 due to conditions that are associated with reduced blood CoQ10 levels.† Requiring no conversion from ubiquinone to ubiquinol, UBQH is ready to support nervous system and cardiovascular health in these populations.†

REFERENCE: Hosoe K, Kitano M, Kishida H, Kubo H, Fujii K, Kitahara M. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol 2007;47:19-28.

Doesn't this suggest that supplementing with UBQH isn't effective because there were no relevant changes in blood work? Maybe my tired eyes are making me stupid right now, lol.

[austinite]

So the ubiquinol one would purchase from other companies is unstable? Does this mean the compound will not be absorbed? You are one of the most vocal supporters of NOW Foods, so does this mean this is one compound you shouldn't trust NOW Foods with?

No. It means it converts back to CoQ10 in the presence of oxygen. The patented version prevents it from oxidizing. It stays stable and is delivered as potent as it should be and studies show serum level difference. Now... it's possible that someone may have copied the patented formula, however, for me.. I'll trust the originators.

[austinite]

I'm going to bed. I'll answer any questions tomorrow. Fingers are numb.

[austinite]

Doesn't this suggest that supplementing with UBQH isn't effective because there were no relevant changes in blood work? Maybe my tired eyes are making me stupid right now, lol.

no..

[basketballfan22]

I guess they meant there were no adverse changes in blood work. I misinterpreted it as saying there were no changes at all (positively or negatively) in the blood work including CoQ10 levels.

[austinite]

Yes. They were looking for issues that may arise, potency, function as well as CoQ10 once administered, etc... this study was cited by the manufacturer themselves, it's a good thing.

[austinite]

Scholar. I'm going to check this out. My monthly natty supplement bill has gone up significantly since I joined here, I'll have you know Mr.!

lol. Just remember, it could always be worse... (like my bill)

[Java Man]

Not so sure. My supp shelf is starting to look like yours!

[austinite]

Not so sure. My supp shelf is starting to look like yours!

Welcome to the club

[austinite]

Blood work next week!

[basketballfan22]

Blood work next week!

You haven't started supplementing with UBQH yet have you? If your blood work shows that your CoQ10 levels are in the upper range, will you continue to supplement with basic CoQ10?

[austinite]

You haven't started supplementing with UBQH yet have you? If your blood work shows that your CoQ10 levels are in the upper range, will you continue to supplement with basic CoQ10?

lol. of course I'm on UBQH, notice the thread title...

[basketballfan22]

lol. of course I'm on UBQH, notice the thread title...

I thought it was a title reflecting an immediate decision, as in you just decided to drop CoQ10 last night. Smartass!

Out of curiosity, did you have your CoQ10 levels checked before? If so, how much improvement did you experience? Your level of CoQ10 was 0.86 (units?), so what is the optimal range?

[austinite]

I thought it was a title reflecting an immediate decision, as in you just decided to drop CoQ10 last night. Smartass!

Out of curiosity, did you have your CoQ10 levels checked before? If so, how much improvement did you experience? Your level of CoQ10 was 0.86 (units?), so what is the optimal range?

lol. ok... This was the first time I check my levels, which was disappointing considering I supplement with CoQ10 daily for years now.

read the thread again, sparky! levels and ranges are posted.

[basketballfan22]

lol. ok... This was the first time I check my levels, which was disappointing considering I supplement with CoQ10 daily for years now.

read the thread again, sparky! levels and ranges are posted.

Oops, sorry I missed that; but you said the upper range is over 3 µg/mL. I assume you can have too much CoQ10, so what is the upper limit? Your attachment shows that you have a CoQ10 level of 0.86. I am assuming that is not in µg/mL; otherwise you are quite short from where you want to be.

[austinite]

Oops, sorry I missed that; but you said the upper range is over 3 µg/mL. I assume you can have too much CoQ10, so what is the upper limit? Your attachment shows that you have a CoQ10 level of 0.86. I am assuming that is not in µg/mL; otherwise you are quite short from where you want to be.

the range is 0.30-3.84. So logically, the upper range would be over 3.0. My result was 0.86, aka very weak. So yes, I am incredibly short from where I need to be.

[Brazensol]

Did you ever get your blood tested after starting UBQH. It is rather spendy and would like to see how it worked on you.

[austinite]

Yes, 100 mg daily took me to 1.9 in just a month.

[Brazensol]

Always nice to hear real world success. I'll be ordering me some of that!

[austinite]

Always nice to hear real world success. I'll be ordering me some of that!

Me too! Lol...

[Brazensol]

Better make it a rush order... lol. Do you get yours from Amazon?

[austinite]

Yup!

[ac guy]

Dude, you are the EF Hutton of supps ( that's a reference for us old bastards) lol

[ppwc1985]

Dude, you are the EF Hutton of supps ( that's a reference for us old bastards) lol

I agree totally, but he needs to make up his mind cause I just bought 3 month supply if Coq10. Loool.

[austinite]

I agree totally, but he needs to make up his mind cause I just bought 3 month supply if Coq10. Loool.

Sorry bud. I announced in all my threads that i made the switch, haven't had FTP access in a while so I'm unable to update the image protocol. So I actually did make up my mind

[ppwc1985]

Sorry bud. I announced in all my threads that i made the switch, haven't had FTP access in a while so I'm unable to update the image protocol. So I actually did make up my mind

Jk austinite

[austinite]

I know

[Joseph956]

My only "thing" with supplementing with something like this would be that I'm already going to be on 5mg of Cialis daily, perhaps even 2x day.. so doesn't that already help blood flow, lower BP and in turn heart health?

I might be thread hi-hacking here, but I don't have the kind of salary that can afford me to have a supplement shelf like Walgreens :P

So at the sake of doubling up on something that I'm just going to urinate because my body has enough of it OR have something which is only helping something that is already receiving help I'd rather save my money OR buy some more Cialis (in this case).

[austinite]

My only "thing" with supplementing with something like this would be that I'm already going to be on 5mg of Cialis daily, perhaps even 2x day.. so doesn't that already help blood flow, lower BP and in turn heart health?

I might be thread hi-hacking here, but I don't have the kind of salary that can afford me to have a supplement shelf like Walgreens :P

So at the sake of doubling up on something that I'm just going to urinate because my body has enough of it OR have something which is only helping something that is already receiving help I'd rather save my money OR buy some more Cialis (in this case).

If you're looking for Lowering blood pressure and blood flow, stick to cialis. But there is a ton of benefit from both that the other cannot provide. Check out the Cialis thread and compare benefits.

[cj111]

Man at first glance that picture you attached.. I thought it was of a toilet, and you know what inside!
On closer inspection, its a pill bottle... sigh

[austinite]

Man at first glance that picture you attached.. I thought it was of a toilet, and you know what inside!
On closer inspection, its a pill bottle... sigh

hahahahahaha. FUNNY! Because the other day I was scrolling through my phone pics, and I thought someone F*cked with me and took a pic of a turd. Had to look closely to remember. lmao.

[Lockout888]

Austinite, have any of the CoQ10 products improved in absorption?

What are your thoughts on: Doctor's Best High Absorption Coq10 w/ BioPerine?

[wellshii]

Good info.
Wonder what ones levels are when everything else the is essential are met through diet and supps(dha,epa,vitmamins ,choline ,etc)
and toxins are avoided as much as possible.
Guess I'll get checked to find out.

[gymffiti]

Great find Austinite

I know someone who is trying to lower their BP. This maybe a good addition to their supps