Austinite or someone else on cutting edge of supplements , , ,question.

**David LoPan** · 11-11-2013, 11:44 PM

1. A 2003 review of studies on 250 nutritional supplements, published in the Journal of Applied Physiology, concluded that only two -- creatine and HMB --had evidence to support their use as a lean muscle builder. In fact, lean gain with creatine and HMB was double that of a placebo, according to researchers. Has there been any other studies that relate to this. Im not really familar with HMB and I didnt see it on your list?

2. DHEA - a recent study of DHEA in the New England Journal of Medicine failed to find any of the benefits men expect from a muscle booster. The two-year study followed 87 men and 57 women ages 60 and older who had low DHEA levels. Although supplements did raise DHEA levels to normal, researchers found no significant changes in muscle strength or body composition. DHEA reduces good cholesterol, so it's not a heart-healthy choice. Plus, there's the unwanted side effect of extra estrogen. I am on TRT, have been taking DHEA but now I am not sure if I should continue it. Your thoughts?

3. L-Arginine - A 2006 study published in the Journal of the American Medical Association found that taking a daily supplement with 9 grams of arginine may cause heart attack or even death in men with known -- and unknown -- heart disease. I see you take 3 grams, do you see a good risk benefit with the increases your body's production of nitric oxide?

4. Lastly, I see you take aspirin in the am? I wish I could find the study, but I have read that taking 81 mg of asa in the PM works much better. When I find the artical I will post it. Just wanted to know what you think.

**David LoPan** · 11-12-2013, 12:11 AM

just did a fast search on ASA, (aspirin)
May 15, 2002 -- Taking aspirin at the right time may be the key to preventing heart attacks, stroke, and even high blood pressure. The common yet potent drug works best at bedtime, a Spanish study shows.

Ramon C. Hermida, PhD, of the University of Vigo, Spain, reported the findings at this week's annual meeting of the American Society of Hypertension.

"Timed administration of low-dose aspirin could be a valuable approach not only for the prevention of major cardiovascular events, but also for the control of blood pressure in patients with mild-to-moderate [high blood pressure]," Hermida says in a press release.

Low-dose aspirin is known to reduce the risk of heart attack in high-risk patients. It also seems to help lower high blood pressure, but studies looking at this effect yield confusing results. Now there may be an explanation: aspirin only lowers blood pressure when taken at bedtime.

Hermida's team studied 109 men and women with mild high blood pressure. All of them went on a diet-and-exercise regimen. They were randomly assigned to three groups. One group didn't take any aspirin. A second group took a low-dose aspirin every morning when they got up. The third group took a low-dose aspirin every night when they went to bed.

Aspirin didn't affect blood pressure if given in the morning. But when given at night, it had a significant effect: a 7.0 mmHg decrease in systolic blood pressure (the top number in a blood-pressure reading) and a 4.8 mmHg decrease in diastolic blood pressure (the bottom number).

Hermida suggests that the body might absorb aspirin more quickly in the morning than at night. He advises researchers to look at when aspirin is given in future studies.

Heart attacks and strokes peak in the early morning hours, even before most men would have a chance to take their preventive aspirin. In theory, then, taking aspirin at bedtime would provide maximum platelet inhibition and protection during this vulnerable period. And a 2005 Spanish study found that morning doses of aspirin raise blood pressure, while bedtime doses lower it.

**MajorPectorial** · 11-12-2013, 02:16 AM

Was 23 when I had my first heart attack (or similar). Was diagnosed with quite severe s.v.t. heart goes OVER 240bpm. Its scary. N u get the cold ache in arm n joints there. Go cold n clammy the lot!. Had two attacks altogether n one op but with TWO ablations instead of one. Getting back into gym. Eating healthy. Cutting back drink and for some reason cycling has helped a great deal.
All I need to do now is nail sleeping long enough every night. Been awake all night yet again. Well annoying

**kelkel** · 11-12-2013, 10:32 AM

Originally Posted by BigTahl

1. A 2003 review of studies on 250 nutritional supplements, published in the Journal of Applied Physiology, concluded that only two -- creatine and HMB --had evidence to support their use as a lean muscle builder. In fact, lean gain with creatine and HMB was double that of a placebo, according to researchers. Has there been any other studies that relate to this. Im not really familar with HMB and I didnt see it on your list?

Best site out for vitamins / supplements: Creatine - Scientific Review on Usage, Dosage, Side Effects | Examine.com
HMB - Scientific Review on Usage, Dosage, Side Effects | Examine.com

2. DHEA - a recent study of DHEA in the New England Journal of Medicine failed to find any of the benefits men expect from a muscle booster. The two-year study followed 87 men and 57 women ages 60 and older who had low DHEA levels. Although supplements did raise DHEA levels to normal, researchers found no significant changes in muscle strength or body composition. DHEA reduces good cholesterol, so it's not a heart-healthy choice. Plus, there's the unwanted side effect of extra estrogen. I am on TRT, have been taking DHEA but now I am not sure if I should continue it. Your thoughts?

Plenty of studies to show the opposite and this really is not a geriatric community. Balancing hormones and replenishing them as we age is vital to maintaining youthfulness and vigor as we age. Here's just one study: [Positive effects of DHEA therapy on ... [Endokrynol Pol. 2005 Nov-Dec] - PubMed - NCBI. Sounds like that recent study that just came out a week or so ago saying testosterone therapy is bad for you. So flawed it wasn't funny.

3. L-Arginine - A 2006 study published in the Journal of the American Medical Association found that taking a daily supplement with 9 grams of arginine may cause heart attack or even death in men with known -- and unknown -- heart disease. I see you take 3 grams, do you see a good risk benefit with the increases your body's production of nitric oxide?

Anything can have a negative effect if used improperly. Read the side effects of Vit C and you'd think it would be a controlled substance.

4. Lastly, I see you take aspirin in the am? I wish I could find the study, but I have read that taking 81 mg of asa in the PM works much better. When I find the artical I will post it. Just wanted to know what you think.

Above in bold...IMHO.

**David LoPan** · 11-12-2013, 06:38 PM

Thanks for the replies. I am a nurse so I do like research. Seems like you can always find one study that says one thing and another that will say the opposite. I am a nurse so I like evidenced based information, so that is why I am asking. Major I am sorry to hear about your heart attack. I would recommend everyone start taking a low dose aspirin daily. Its cheap and very effective for heart problems. I started taking it 20 years ago, wow I'm now that old (45), due to have a doctor in my family that said "its better to take it and not need it, then need it and not take it".

Kelkel, thanks for the links. I am on TRT, I do take DHEA among a few other supplements but I don't use creatine and HMB. I did a search on here about HMB and found nothing. I also take CLA and found nothing on here about it as well. That is why I asked. I think I might just start taking Creatine and HMB. I know I should be on HCG but cant find a good place to get at a good price, due to the weight loss fad around here with the women using HCG and the 500 cal diet.

Thanks again for your replies. I aways find great help on here. Most by reading, some by posting questions.