Diphenhydramine and Beta 2 receptors

[RangerDanger830]

Does Diphenhydramine (sleep aid/benadryl) affect beta 2 receptors? Months ago I was doing research and stumbled upon some broscience stating it upregulates them so taking it on your off cycles from clen would provide better results. It has been in my mind for awhile and upon searching I cannot find anything supporting this hypothesis or denying it with peer reviewed studies although they must be out there. Has anyone researched this before and found anything conclusive?

The following conclusion seems solid to me, am I missing any holes in this theory?

Wouldn't be a bad idea to change the profile description of clen on the steroid profiles page. It still supports bendryl as an option.

Quote:
Another option, if you are worried about receptor downgrade, is taking Benadryl, at around 50-100mgs/night before bed (every 3rd week or so, for that week). Benadryl is sold as an anti-histamine in the United States, and/or a sleep aid elsewhere in the world. However, Beta receptors are embedded in the cell´s outer phospholipid membrane. The stability of the membrane has a lot to do with the proper function of the receptors. Methylation of the phospholipids is stimulated by the binding of beta agonists to their receptors. Methylated phospholipids are foreign to the body, and when the body recognizes them as foreign, it breaks them down with phospholipase A2. This changes the structure of the outer membrane which results in desensitization of the beta receptors. On the other hand, agents that inhibit phospholipase A2 slow desensitization.

Cationic ampiphylic drugs are known for their ability to inhibit phospholipase A2. Benadryl (diphenhydramine) is a cationic ampiphylic drug.

Ergo, Benadryl slows desensitization of Beta receptors (i.e. Upgrades them) by inhibiting phospholipase A2, which is the enzyme that breaks down methylated phospholipids, and this action in turn keeps the phospholipid membrane stable, and thus keeps the receptors functioning properly. (7). This will allow you to use clen for much longer and it´ll still have the same effects. Also, since Benadryl is an anti-histamine, and histamines have a direct effect on beta-adrenoreceptors (not just Beta-2´s but all of them), using an anti-histamine will have a direct effect on reducing beta-receptor stimulation (16), and thus upregulating your beta-receptors.

[Bonaparte]

Benadryl does not, but ketotifen does.

[RangerDanger830]

Benadryl does not, but ketotifen does.

I know keto does, the reason I am asking isn't necessarily for a clen cycle. I have sleep issues for personal reasons and my doc prescribed ambien. Well I sleep too deeply with ambien, my alarm will not wake me up and I feel like death in the mornings. I decided to avoid the ambien and take the benadryl from time to time on days I haven't been very active to help me sleep. I was worried that taking keto and benadryl might be in some way hindering clen's effectiveness if it did indeed upregulate the clen in combination with the keto. Where did you learn that benadryl doesn't?

[Bonaparte]

I know keto does, the reason I am asking isn't necessarily for a clen cycle. I have sleep issues for personal reasons and my doc prescribed ambien. Well I sleep too deeply with ambien, my alarm will not wake me up and I feel like death in the mornings. I decided to avoid the ambien and take the benadryl from time to time on days I haven't been very active to help me sleep. I was worried that taking keto and benadryl might be in some way hindering clen's effectiveness if it did indeed upregulate the clen in combination with the keto. Where did you learn that benadryl doesn't?

Upregulating Beta-2 receptors would make your clen more effective, not the other way around.
And Benadryl has never been shown to affect beta-2 receptors. Guys just falsely assumed it did because it is also an antihistamine.

[RangerDanger830]

Upregulating Beta-2 receptors would make your clen more effective, not the other way around.
And Benadryl has never been shown to affect beta-2 receptors. Guys just falsely assumed it did because it is also an antihistamine.

Fair enough, I know it sounds elementary but I wasn't sure if it was possible to upregulate them too much. Oh well, thanks for the input.

[Ashop]

Does Diphenhydramine (sleep aid/benadryl) affect beta 2 receptors? Months ago I was doing research and stumbled upon some broscience stating it upregulates them so taking it on your off cycles from clen would provide better results. It has been in my mind for awhile and upon searching I cannot find anything supporting this hypothesis or denying it with peer reviewed studies although they must be out there. Has anyone researched this before and found anything conclusive?

The following conclusion seems solid to me, am I missing any holes in this theory?

Like you said,,,a lot of bro science. Most my people use KETO .The only real way to know is try it for
yourself.