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  1. #1
    wyuoiea is offline New Member
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    Two-Month plan to increase Testosterone / reduce SHBG using supplements

    Iíve had low free/bioavailable testosterone for years and I am now attempting to resolve this. Would appreciate any advice.

    I just got this yearís lab work back. I actually have decent T production, but no Free or Bioavailable with my SHBG numbers waaaay high.

    My doc has agreed with my plan to increase Vit D supplements from 4K IU daily to 10K IU. Heís ordered lab work to test my Vit D, T and SHBG in two months. So I want to try and do anything possible that will move my T up and SHBG down.

    Iím 51, 177lb, 5í7Ē. Iíve reduced booze intake (none for the last month), I've lost weight through a diet as healthy and low-fat as I can get it and Iím monitoring and trying to improve the quantity and quality of my sleep. Iím engaged in martial arts and do moderate weight lifting (2x week, Starting Strength program) that I canít really change. Iíve reduced caffeine significantly. I will try to lose an additional 5lbs of pudge. I canít change my stress levels.

    Currently taking daily (results should be reflected in the 8/2014 & 11/2013 lab work):
    Vitamin D3 Ė 4k IU
    Aspirin - 83mg
    Fish Oil - 4k (1200 mg Omega 3)
    Magnesium - 400 mg
    Zinc - 50 mg
    B6 - 25 mg

    My supplement program for the next two months will be:
    Vitamin D3 Ė increase to 10k IU daily
    Solaray Saw Palmetto & Nettle w/Pumpkin MultiSup
    Nettle (Urtica dioica)(root extract) 600mg daily
    Pumpkin (Cucurbita pepo) (seed oil) 400mg daily
    Saw Palmetto (Serenoa repens) (berry oil) 320 mg daily

    Iím willing to try almost any other supps that anyone recommends just to see if I can move the numbers in the next two months.

    Here are my past test results.
    8/18/14 Lab Results
    Vit D, 25-OH, Total: 70. Ref Range 30-100 nb/mL
    Testosterone , Free, Bio and Total, LC/MS/MS Testosterone, Total
    683. 250-1100 ng/dL
    Testosterone, Free 43.0. 46.0-224.0 pg/mL
    Testosterone, Bioavailable 84.6 L. 110.0-575.0 ng/dL
    Sex Hormone Binding Globulin 80. 9-45 nmol/L
    Albumin, Serum 4.3. 3.6-5.1 g/dL

    11/04/13 Lab Results
    Vitamin D, 25-OH, Total 73. 30-100 ng/mL
    Testosterone , Free, Bio and Total, LC/MS/MS Testosterone, Total, LC/MS/MS: 638. 250-1100 ng/dL
    Testosterone, Free: 49.5. 46.0-224.0 pg/mL
    Testosterone, Bioavailable: 106.0 L. 110.0-575.0 ng/dL
    Sex Hormone Binding Globulin: 63. 10-50 nmol/L
    Albumin, Serum: 4.7. 3.6-5.1 g/dL

    11/29/11 Lab Results
    Vitamin D, 25-OH, Total 43. 30-100 ng/mL
    Testosterone , Free, Bio and Total, LC/MS/MS Testosterone, Total, LC/MS/MS: 479. 250-1100 ng/dL
    Testosterone, Free: 51.2. 46.0-224.0 pg/mL
    Testosterone, Bioavailable: 105.2 L. 110.0-575.0 ng/dL
    Sex Hormone Binding Globulin: 43. 10-50 nmol/L
    Albumin, Serum: 4.5. 3.6-5.1 g/dL

    10/1/08 Lab Results
    Testosterone , Free, Bio and Total, LC/MS/MS Testosterone, Total: 612. 250-1100 ng/dL
    Testosterone, Free: 65.1. 46.0-224.0 pg/mL
    Testosterone, Bioavailable: 133.9 L. 110.0-575.0 ng/dL
    Sex Hormone Binding Globulin: 45. 9-45 nmol/L
    Albumin, Serum: 4.5. 3.6-5.1 g/dL

    Any other ideas?

  2. #2
    wyuoiea is offline New Member
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    Bumping....anyone have any ideas on supplements to increase T and decrease SHBG?
    I have a great opportunity to test and check results.

    If no one has an opinion, anyone know of any other sources I could check with?

  3. #3
    wyuoiea is offline New Member
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    Hereís info I could find on some supps that could help.

    D-aspartic acid:
    Reprod Biol Endocrinol. 2009 - PubMed - NCBI
    RESULTS:
    In humans and rats, sodium D-aspartate induces an enhancement of LH and testosterone release. In the rat pituitary, sodium D-aspartate increases the release and synthesis of LH through the involvement of cGMP as a second messenger, whereas in rat testis Leydig cells, it increases the synthesis and release of testosterone and cAMP is implicated as second messenger. In the pituitary and in testes D-Asp is synthesized by a D-aspartate racemase which convert L-Asp into D-Asp. The pituitary and testes possesses a high capacity to trapping circulating D-Asp from hexogen or endogen sources.
    CONCLUSION:
    D-aspartic acid is a physiological amino acid occurring principally in the pituitary gland and testes and has a role in the regulation of the release and synthesis of LH and testosterone in humans and rats.
    That sounds goodÖ.

    And another study found:
    Total and free testosterone, luteinizing hormone, gonadotropin-releasing hormone, and estradiol were unchanged with resistance training and d-aspartic acid (D-ASP) supplementation (P > .05).
    But it also said...

    For serum D-ASP and d-aspartate oxidase (DDO), D-ASP resulted in a slight increase compared with baseline levels (P > .05). For the D-ASP group, the levels of serum DDO were significantly increased compared with placebo (P < .05). The gonadal hormones were unaffected by 28 days of D-ASP supplementation and not associated with the observed increases in muscle strength and mass. Therefore, at the dose provided, D-ASP supplementation is ineffective in up-regulating the activity of the hypothalamo-pituitary-gonadal axis and has no anabolic or ergogenic effects in skeletal muscle.
    Iím not really sure what that means. Do I want more d-aspartate oxidase (DDO)?


    Hereís my stuff for ďVit D Could HelpĒ

    Old RDA of Daily D is probably too low

    Am J Clin Nutr January 2007 vol. 85 no. 1 6-18
    Risk assessment for vitamin D1,2
    ÖCollectively, the absence of toxicity in trials conducted in healthy adults that used vitamin D dose ≥250 μg/d (10 000 IU vitamin D3) supports the confident selection of this value as the UL.
    Low D + Low T is really bad
    Clin Endocrinol (Oxf). 2012 Sep;77(3):475-83.
    ÖCombination of low free testosterone and low vitamin D predicts mortality in older men referred for coronary angiography.
    Vit D may increase T
    Horm Metab Res. 2011 Mar;43(3):223-5.
    Our results suggest that vitamin D supplementation might increase testosterone levels.
    and

    Clin Endocrinol (Oxf). 2012 Jul;77(1):106-12.
    This study supports previously reported positive associations between vitamin D and testosterone although we did not observe parallel seasonal variation patterns. Possible causality and direction of the vitamin D-testosterone association deserve further scientific investigation.

  4. #4
    wyuoiea is offline New Member
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    Quote Originally Posted by wyuoiea View Post

    My supplement program for the next two months will be:
    Vitamin D3 Ė increase to 10k IU daily
    Solaray Saw Palmetto & Nettle w/Pumpkin MultiSup
    Nettle (Urtica dioica)(root extract) 600mg daily
    Pumpkin (Cucurbita pepo) (seed oil) 400mg daily
    Saw Palmetto (Serenoa repens) (berry oil) 320 mg daily
    Ok results.
    For the period of 8/28-10/30 I followed the supplement protocol above.
    Iíd say, overall, results were positive: Total T decreased slightly (bad). Free T increased (good). Bioavailable T increased (good). SHBG decreased considerably (good)

    10/31/14 lab results
    Vit D, 25-OH, Total: 92. (30-100 nb/mL is considered normal) >>>>Increase of 22 (I donít know if this is good or bad)
    Testosterone , Free, Bio and Total, LC/MS/MS Testosterone,
    Total 629 (250-1100 ng/dL is considered normal) >>>>Decrease of 54 (a decrease is BAD)
    Testosterone, Free 61.8 (46.0-224.0 pg/mL is considered normal) >>>>>Increase of 18.8 (an increase is GOOD)
    Testosterone, Bioavailable 129.8 L (110.0-575.0 ng/dL is considered normal) >>>>>Increase of 45.2 (an increase is GOOD)
    Sex Hormone Binding Globulin 49 (9-45 nmol/L is considered normal) >>>>>>>Decrease of 31 (a decrease is GOOD)
    Albumin, Serum 4.6 (3.6-5.1 g/dL is considered normal) >>>>Increase of 0.3 (I donít know if this is good or bad)

    I don't know a lot about this subject, so I'm not sure if my numbers would have swung the way they did in a two month period without the protocol I followed. But there seems to have been a positive change.

    The recommended Solaray dose was 1 capsule 3x a day - I always took 3 capsules at once in the morning. I forgot to take this 2x during this period.

    2 weeks into this period stopped heavy lifting due to injury. When I stopped lifting I started drinking more booze, eating more crap and increased body fat. Those factors should have helped decrease the Total T numbers.

    Other than that, Iím not a scientist so I donít really have a qualified opinion on how this all worked. But is seems to have been a positive result.

    Would love to hear any comments or opinions on this.

  5. #5
    Khazima's Avatar
    Khazima is offline Knowledgeable Member
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    Great thread and layout man hopefully kelkel can come in and shed some light on the results.

  6. #6
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    fitnesstrainer is offline Associate Member
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    This is an instance where a quality test booster may come in handy. Very rarely do I recommend them but this is a case where I would.

  7. #7
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    VoRTeXO77 is offline New Member
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  8. #8
    kelkel's Avatar
    kelkel is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~ No Source Checks
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    Seems like you're pretty much on top of things and making progress. A couple thoughts:

    Closely continue to follow your D3 level. Keep it near the top but don't go excessively over as it's fat soluble and becomes toxic over time.
    Try to make one change at a time. Otherwise you won't know how to gauge results.
    A consideration would be Danazol to help reduce shbg. It may give you a needed bump (down) and your protocol may then help maintain a better level.
    Other than that, the quickest way to reduce shbg is to increase testosterone .

    Great thread and work on your part. Keep updating please.
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