Sam e for depression?

[edmundo22]

Anyone have any experience with this supplement?, Iv read some glowing reports about it like its a magic bullet for depression but Iv been on it for 3 weeks and think it might just be snake oil.

[hammerheart]

Sam-e is some expensive sh*t. It works (for some), provided the pills are enteric-coated (ie. dissolve in the intestines) as stomach acid degrades the molecule.

There are some way around to get your endogenous AdoMet (different name, same compound) up, by 1) supplement with l-methionine; 2) fueling remethylation from homocysteine (healthier). The enzymes that perform this operation are called methionine synthases. You got two classes of them. The first is cobalamin (Vit. B12) dependent and the second takes betaine as a cofactor.

So you got your recipe: instead of Sam-E, you could supplement (for cheaper) with methionine, betaine (trimethylglycine) and/or the active form of B12 (methlycobalamin).

Creatine also is able to raise available adomet since endogenous synthesis takes up a lot of methyl groups from it.

Another very effective supplement for depression is P5P, tha activated form of B6.


I have no direct esperience with Same but the ones I mentioned above are effective for me.

[Ashop]

Sam-e is some expensive sh*t. It works (for some), provided the pills are enteric-coated (ie. dissolve in the intestines) as stomach acid degrades the molecule.

There are some way around to get your endogenous AdoMet (different name, same compound) up, by 1) supplement with l-methionine; 2) fueling remethylation from homocysteine (healthier). The enzymes that perform this operation are called methionine synthases. You got two classes of them. The first is cobalamin (Vit. B12) dependent and the second takes betaine as a cofactor.

So you got your recipe: instead of Sam-E, you could supplement (for cheaper) with methionine, betaine (trimethylglycine) and/or the active form of B12 (methlycobalamin).

Creatine also is able to raise available adomet since endogenous synthesis takes up a lot of methyl groups from it.

Another very effective supplement for depression is P5P, tha activated form of B6.


I have no direct esperience with Same but the ones I mentioned above are effective for me.

Interesting information. Definitely caught my interest especially with an all natural formula.

[edmundo22]

Iv been on it for 3 weeks haven't noticed any difference, too expensive to stay on it, anyone know any miracle cures for depression?

[hammerheart]

Iv been on it for 3 weeks haven't noticed any difference, too expensive to stay on it, anyone know any miracle cures for depression?

You ever tried l-tryptophan? Also give P5P a try.

What kind of depression are you experiencing? Do you feel rather melancholic or lethargic? How much do you sleep? It gets bettter or worse through the day?

[InternalFire]

Iv been on it for 3 weeks haven't noticed any difference, too expensive to stay on it, anyone know any miracle cures for depression?

I have self medicated with nicotine gum meditation education and lots of supplements which you can look up on the first post of my log.
Most supplements I continue to use till today I just no longer use nicotine gum and meditate very seldom. Nicotine gum always given me calm equilibrium of self sense and so I could start going any positive direction required for me to get on the right track. A month or two and was out of depression for good. Hope it helps

[edmundo22]

Thanks for the replys, yeah I tried L tryptofan worked great for a while but think I developed a tolerance to it, I have major depression along with psychotic symptoms the depression can be hell at times been dealing with it for 18 years now on account I got addicted to inhaling gasoline every day of the week, smart choice curiosity got the best of me just the one time then full blown addiction after that for a full year, just started a new medication today feeling better Iv read it increase prolactin though leading to weight gain n man boobs but if it works I don't mind, Never heard about nicotine been therapeutic already vaping so that's that covered.

[hellomycognomen]

Have you tried St. John's Wort? Aside from several drug interactions many people swear by its anti-depressant effects. I was on it for a short while, I felt uplifted, not sure if it was placebo effect. I stopped however because I was slowly losing libido. I would recommend that whatever you do, take each supplement in turn. If you start taking a bunch of stuff it will be hard to deduce which is actually working and which is worth eliminating. -Cheers

[edmundo22]

Have you tried St. John's Wort? Aside from several drug interactions many people swear by its anti-depressant effects. I was on it for a short while, I felt uplifted, not sure if it was placebo effect. I stopped however because I was slowly losing libido. I would recommend that whatever you do, take each supplement in turn. If you start taking a bunch of stuff it will be hard to deduce which is actually working and which is worth eliminating. -Cheers

I havent tried st johns wort but did try 5 htp for a while again up lifting effects but wasnt sure if it was a placebo, fucking sick and tired of depression, been alone constantly, Im making an appointment to see a specialist in Dublin maybe that might help, I havent had any libido since I was 19, great age to loose it never even got to have sex and Im 33 now, fml.

[hellomycognomen]

I havent tried st johns wort but did try 5 htp for a while again up lifting effects but wasnt sure if it was a placebo, fucking sick and tired of depression, been alone constantly, Im making an appointment to see a specialist in Dublin maybe that might help, I havent had any libido since I was 19, great age to loose it never even got to have sex and Im 33 now, fml.

It sounds to me like you have the classic symptoms of low testosterone . Get checked, that might be the source of all your problems.

[hammerheart]

I havent tried st johns wort but did try 5 htp for a while again up lifting effects but wasnt sure if it was a placebo, fucking sick and tired of depression, been alone constantly, Im making an appointment to see a specialist in Dublin maybe that might help, I havent had any libido since I was 19, great age to loose it never even got to have sex and Im 33 now, fml.

So you are in Ireland? Try to get hold of Manerix (moclobemide). It is an old but effective antidepressant that might require special diet adaptation, but it doesn't negatively impact libido like modern SSRIs.

[edmundo22]

It sounds to me like you have the classic symptoms of low testosterone. Get checked, that might be the source of all your problems.

Lol no I got my testosterone checked twice turns out its really high 600 ng/dl, i even started taking testosterone anyways hoping that would cure me after reading all the stuff about how good it makes people feel, had a honeymoon period that lasted a week then back into depression Ill look into the Manerix thanks for the suggestion, Im on the verge of either living in a mental hospotal or offing myself.

Iv looked into the manerix read some great success storys, Ill talk to my doctor about it tomorrow cheers for letting me know about it.

[hellomycognomen]

Damn man, in that case see a doc asap to get you some proper meds. I suggest finding some thing that brings you a little joy, a girlfriend, a pet, a hobby.... dont give up mate, your depression has a solution. I would talk to the doc about starting first with SSRI or SNRI before moving to the stronger MAO inhibitors. -Cheers

[edmundo22]

I'm currently on mirtazapine and pregablin, my pdoc in the public service wont put me on a third med no matter how many times Iv asked that's why I'm trying to see a private psychiatrist.

[WordToPass]

oh wow. I am suffering from depression occasionally and I have never heard about this Sam e. bizzaro. thank you for posting that, I would definitely start reading a bit more about it.