Which is better?

[trikydik]

Low reps (12, 10, 8) at higher weight

or

Large quantity of reps at lower weight?

or

Lifting heavy until failure?

[DeadlyD]

All depends on goals ! For mass building I'd say heavy to moderate weights at 8-12 rep range. For cutting up and defining go with lower weight higher reps, and for strength and power heavy weight and low reps, and I always go to failure at least on my last sets.

[jsanman]

id say no matter what amount of reps, always have the target of lifting your last rep to fail,
only those who dare push too far are the ones who really know how far they can push

[hekki]

I've done all 3 in my short time as a gym rat and they each have had its benefits for me. I like alternating between the first 2 every 2 months or so. Keeping my muscles guessing as to what is next has kept helped me keep gains.

[hellomycognomen]

lifting to fail is best but it can be hard to keep an accurate progression log