Well finally some proof that we shouldn't be exercising soo much

[puffy16]

http://www.mayoclinicproceedings.org...577-3/fulltext

Results

We identified 3 distinct PA trajectories: trajectory 1, below PA guidelines (n=1813; 57.1%); trajectory 2, meeting PA guidelines (n=1094; 34.5%); and trajectory 3, 3 times PA guidelines (n=268; 8.4%). Trajectory 3 participants had higher adjusted odds of CAC>0 (adjusted odds ratio [OR], 1.27; 95% CI, 0.95-1.70) vs those in trajectory 1. Stratification by race showed that white participants who engaged in PA 3 times the guidelines had higher odds of developing CAC>0 (OR, 1.80; 95% CI, 1.21-2.67). Further stratification by sex showed higher odds for white males (OR, 1.86; 95% CI, 1.16-2.98), and similar but nonsignificant trends were noted for white females (OR, 1.71; 95% CI, 0.79-3.71). However, no such higher odds of CAC>0 for trajectory 3 were observed for black participants.


Conclusion

White individuals who participated in 3 times the recommended PA guidelines over 25 years had higher odds of developing coronary subclinical atherosclerosis by middle age. These findings warrant further exploration, especially by race, into possible biological mechanisms for CAC risk at very high levels of PA.

[BrockBadger]

http://www.mayoclinicproceedings.org...577-3/fulltext

Results

We identified 3 distinct PA trajectories: trajectory 1, below PA guidelines (n=1813; 57.1%); trajectory 2, meeting PA guidelines (n=1094; 34.5%); and trajectory 3, 3 times PA guidelines (n=268; 8.4%). Trajectory 3 participants had higher adjusted odds of CAC>0 (adjusted odds ratio [OR], 1.27; 95% CI, 0.95-1.70) vs those in trajectory 1. Stratification by race showed that white participants who engaged in PA 3 times the guidelines had higher odds of developing CAC>0 (OR, 1.80; 95% CI, 1.21-2.67). Further stratification by sex showed higher odds for white males (OR, 1.86; 95% CI, 1.16-2.98), and similar but nonsignificant trends were noted for white females (OR, 1.71; 95% CI, 0.79-3.71). However, no such higher odds of CAC>0 for trajectory 3 were observed for black participants.


Conclusion

White individuals who participated in 3 times the recommended PA guidelines over 25 years had higher odds of developing coronary subclinical atherosclerosis by middle age. These findings warrant further exploration, especially by race, into possible biological mechanisms for CAC risk at very high levels of PA.

Nice find. This is to review the actual guidelines: "The Guidelines recommend that adults should do a minimum of 2 hours and 30 minutes, or 30 minutes 5 days a week, of moderate-intensity aerobic activity a week. Health experts recommend this level of activity to reduce the risk of chronic disease later in life." "muscle-strengthening activities on 2 or more days a week that work all major muscle groups (legs, hips, back, abdomen, chest, shoulders, and arms)."

6 hours and 90 minutes... and 6 days of strength training...

Thats like 1 hour a day moderate intensity for 7 days plus 30 minutes extra... So one day would be 1 hour and 30 minutes... 6 days of strength training ill assume 1 hour.

Thats about 2 hours a day every day...

Thats a lot of cardio and strength training.... The study makes sense... Basically, more exercise isn't always better... I may have to lay off a little.... lol

Something to think about though is another study which suggest about 6 hours a day of exercise prevents the telomere ends from shrinking the most.

This supports your find. Something to consider. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581416/

[MuscleScience]

Chronic oxidative stress has been something talked about in the exercise phys literature. Basically in the 90’s and 2000’s a alarming amount of elite level runners from tr 70’s and 80’s started dropping dead from CAD which put them in there late 40’s and 50’s. The thought was that due to the increased amount of reactive oxygen species (free radicals) produced as a byproduct of aerobic exercise. These reactive oxygen molecules were floating around oxidizing and damaging tissues. Oxygen is a highly reactive chemical and for most forms of primitive life, is very toxic.

Because these athletes bodies was producing chronically high levels of these free radicals, they were at a similar or in some studies even, at a higher risk than sedintary adults at developing heart disease.

[Obs]

Chronic oxidative stress has been something talked about in the exercise phys literature. Basically in the 90’s and 2000’s a alarming amount of elite level runners from tr 70’s and 80’s started dropping dead from CAD which put them in there late 40’s and 50’s. The thought was that due to the increased amount of reactive oxygen species (free radicals) produced as a byproduct of aerobic exercise. These reactive oxygen molecules were floating around oxidizing and damaging tissues. Oxygen is a highly reactive chemical and for most forms of primitive life, is very toxic.

Because these athletes bodies was producing chronically high levels of these free radicals, they were at a similar or in some studies even, at a higher risk than sedintary adults at developing heart disease.

Hotter the flame the faster it consumes. I don't see it as scientifically explained but rather a given law.

What if we all have a predetermined amout of energy we can expend before death? Such as a candle...
Burning you candle at both ends = improper medical maitenance.
I believe we all have a final expenditure total. Are you fast and hard or slow and steady? I also dont think we control it much at all in the grand scheme.

[MuscleScience]

Hotter the flame the faster it consumes. I don't see it as scientifically explained but rather a given law.

What if we all have a predetermined amout of energy we can expend before death? Such as a candle...
Burning you candle at both ends = improper medical maitenance.
I believe we all have a final expenditure total. Are you fast and hard or slow and steady? I also dont think we control it much at all in the grand scheme.

There is a universal limit on cardiac muscle and how many times it can beat before failure. I think the number is like 2 billion beats. Pretty much goes for all higher organisms.

[Obs]

There is a universal limit on cardiac muscle and how many times it can beat before failure. I think the number is like 2 billion beats. Pretty much goes for all higher organisms.

Well fuck...
I will be leaving y'all soon.
Don't have a beer for me. Take a gram of tren per week for 16 weeks in honor of me and jerk off to dp once in a while and think about my ugly face.

[charger69]

Well fuck...
I will be leaving y'all soon.
Don't have a beer for me. Take a gram of tren per week for 16 weeks in honor of me and jerk off to dp once in a while and think about my ugly face.

Obs- no more EC stacks!

[Obs]

Obs- no more EC stacks!

Lmfao! If you only knew how much I had a few hours ago!

[tarmyg]

Like anything more is not always better and this should seem obvious to most but not something we always live by. From a personal perspective, I know my level of training is not, necessarily, healthy but the purpose is not health, it's to become the best.

[MuscleScience]

Well fuck...
I will be leaving y'all soon.
Don't have a beer for me. Take a gram of tren per week for 16 weeks in honor of me and jerk off to dp once in a while and think about my ugly face.

What I was saying is Your assumption was pretty much spot on. And of course my example was just one aspect within your expenditure analogy. Another is how people who eat a calorically restricted diet typically will live longer than those that gorge.

[MuscleScience]

Well fuck...
I will be leaving y'all soon.
Don't have a beer for me. Take a gram of tren per week for 16 weeks in honor of me and jerk off to dp once in a while and think about my ugly face.

It’s kinda like how in a country and or western song, they talk about burning your candle at both ends. Everyone is born with only so much candle to burn.

[kelkel]

There is a universal limit on cardiac muscle and how many times it can beat before failure. I think the number is like 2 billion beats. Pretty much goes for all higher organisms.

Guess that means I'm running out soon. Great.

[songdog]

Chronic oxidative stress has been something talked about in the exercise phys literature. Basically in the 90’s and 2000’s a alarming amount of elite level runners from tr 70’s and 80’s started dropping dead from CAD which put them in there late 40’s and 50’s. The thought was that due to the increased amount of reactive oxygen species (free radicals) produced as a byproduct of aerobic exercise. These reactive oxygen molecules were floating around oxidizing and damaging tissues. Oxygen is a highly reactive chemical and for most forms of primitive life, is very toxic.

Because these athletes bodies was producing chronically high levels of these free radicals, they were at a similar or in some studies even, at a higher risk than sedintary adults at developing heart disease.

Thanx MS you took the words right out of my mouth :/

[puffy16]

Chronic oxidative stress has been something talked about in the exercise phys literature. Basically in the 90’s and 2000’s a alarming amount of elite level runners from tr 70’s and 80’s started dropping dead from CAD which put them in there late 40’s and 50’s. The thought was that due to the increased amount of reactive oxygen species (free radicals) produced as a byproduct of aerobic exercise. These reactive oxygen molecules were floating around oxidizing and damaging tissues. Oxygen is a highly reactive chemical and for most forms of primitive life, is very toxic.

Because these athletes bodies was producing chronically high levels of these free radicals, they were at a similar or in some studies even, at a higher risk than sedintary adults at developing heart disease.

I am curious where did you read about Oxidative stress in the article? I read the whole article and couldn't find any indication of oxidative stress and only one mention of word stress at all when referring to heart rate.

[Couchlock]

Newbs don't need to hear this.

Exersize to your hearts content. It makes you live longer., period.

There are exceptions, but this is going to be a mental hurdle for those first starting out when they lack motivation and energy due to new diet and lifestyle till their bodies adjust

"I'm,a bit tired today, don't feel like cardio/lifting, but hey that's ok, too much can kill me"......

[BrockBadger]

Newbs don't need to hear this.

Exersize to your hearts content. It makes you live longer., period.

There are exceptions, but this is going to be a mental hurdle for those first starting out when they lack motivation and energy due to new diet and lifestyle till their bodies adjust

"I'm,a bit tired today, don't feel like cardio/lifting, but hey that's ok, too much can kill me"......

Yeah this is true... I mean realistically most are not even close to the physical activity recommendations... much less twice as much, much less as 3 times as much. This is just for the die-hard no pun intended...

[BrockBadger]

Chronic oxidative stress has been something talked about in the exercise phys literature. Basically in the 90’s and 2000’s a alarming amount of elite level runners from tr 70’s and 80’s started dropping dead from CAD which put them in there late 40’s and 50’s. The thought was that due to the increased amount of reactive oxygen species (free radicals) produced as a byproduct of aerobic exercise. These reactive oxygen molecules were floating around oxidizing and damaging tissues. Oxygen is a highly reactive chemical and for most forms of primitive life, is very toxic.

Because these athletes bodies was producing chronically high levels of these free radicals, they were at a similar or in some studies even, at a higher risk than sedintary adults at developing heart disease.

Excellent example on this subject.

[MuscleScience]

I am curious where did you read about Oxidative stress in the article? I read the whole article and couldn't find any indication of oxidative stress and only one mention of word stress at all when referring to heart rate.

It wasn’t, it’s just a controversial theory in the exercise phys scientific literature as a proposed mechanism for why extreme endurance athletes drop dead early.

[Chicagotarsier]

I personally think the highest item on the flagpole for CAD is genetics.

In the words of Ricky Bobby:

Lucius Washington: You're not gonna live forever.

Ricky Bobby: No one lives forever, no one. But with advances in modern science and my high level income, it's not crazy to think I can live to be 245, maybe 300. Heck, I just read in the newspaper that they put a pig heart in some guy from Russia. Do you know what that means?

Lucius Washington: No, I don't know what that means. I guess longer life.

Ricky Bobby: No, he didn't live. It's just exciting that we're trying things like that

[Chicagotarsier]

It wasn’t, it’s just a controversial theory in the exercise phys scientific literature as a proposed mechanism for why extreme endurance athletes drop dead early.

Doctors in general are ANTI IGF. Anything that raises IGF is evil to them. They focus on the incurable items like cancer as the focus of life. Anything to avoid the cancer has to be good right.

Ask Bolo Yeung how much high IGF impacted him as an elite bodybuilder and later life living. He is still kicking and living a good life.

Everyone in the world has to have something that makes them relevant. Clucking about Oxidative Stress gets research students money from groups that benefit from treatment surrounding Oxadative Stress. We are back to Big Pharma...any questions?

[Obs]

Doctors in general are ANTI IGF. Anything that raises IGF is evil to them. They focus on the incurable items like cancer as the focus of life. Anything to avoid the cancer has to be good right.

Ask Bolo Yeung how much high IGF impacted him as an elite bodybuilder and later life living. He is still kicking and living a good life.

Everyone in the world has to have something that makes them relevant. Clucking about Oxidative Stress gets research students money from groups that benefit from treatment surrounding Oxadative Stress. We are back to Big Pharma...any questions?

I don't know much about a lot of the oxidative stress but...
MONEY