GW501516 - where are we now?
Okay, so I’m wondering about GW501516 aka Cardarine / Endurobol.
(Yes I know it’s now a steroid, but it ain’t a peptide either)
So, basically what i am contemplating about it is ofcourse cancer risk.
What really concerns me about this is that I read several places that the study showing rats forming cancer from GW501516 is cited as being equivalent of humans taking enormous dosages of aspirin.
As someone with over the average molecular biology know how, I can tell you that you DO NOT convert mg/kg in a rat to the same mg/kg in a human.
So if a rat dies after taking 100mg/kg, and is fine with 50mg/kg, IT DOES NOT mean that a human can take 50mg/kg and be fine. Not at all.
When you translate from animals to humans you take size and surface volume (and maybe other factors) into consideration as well.
If you look at LD50 (lethal dose for 50% of test subjects) for a given drug, and see what it is for different animals, you’ll often see something like this;
Rat: 100mg/kg
Rabbit: 80mg/kg
Dog: 60mg/kg
...
Elephant: LOL
You see where this is going right?
But other arguments against the cancer thing I’ve heard that makes more sense is that peroxisome proliferators act very different in rats vs humans.
I’ve also heard the studies saying it causes cancer to be methodologically flawed, however, unless I hear that from a doctor or molecular biologist directly I take that with a grain of salt, as I don’t know if the individual even understand animal to human conversion of drug dosages.
Sooo, what are your opinions folks?
This looks like a so fucking nice chem, except the cancer thing.
And that’s a big thing IMO.
I’m thinking of the star in the Spartacus series f.ex; who died after season 1. He was quite ripped and it wouldn’t suprise me if he had used tons of GW501516,
but that’s pretty much mere speculation on my part.
Point is, you never know, and cancer is a sneaky bitch.
Input from users and anyone having done their homework on this is most welcome.
And users, please tell me how much for how long. Hehe. ;)
(Total)
Be happy and have a great Easter!!