Medical Journals

[BlueWaffle21]

Been talking to a few doctor buddies of mine and none of them believe that high estrogen can lead to cardiac issues of all sorts. They all seem to say the same thing, "well then women would have all the issues as well." I wanted to see if anyone on here has a link to some legit medical studies confirming the cardiac issues brought on by high estrogen. I'm not looking for Wiki stuff but real cardiac journals or studies. Any help would be appreciated!!!!!

[MickeyKnox]

Here ya go. There's a link to PubMed at the bottom of each claim. Give that to your Doc and let chew on it for awhile.


Cardiovascular Dangers of Excess Estrogen

Conventional medical dogma states that estrogen is cardio-protective while androgens are pro-atherogenic. This fallacy is based on the mere fact that men have higher levels of heart disease than women.

Excess estrogen in males has many harmful effects, and is definitely not cardio-protective. The following are just a few of the many research studies demonstrating the harmful cardiovascular effects of excess estrogen in males:

1) Increases Risk of Stroke.
After adjustment for age, hypertension, diabetes, adiposity, cholesterol, atrial fibrillation, and other characteristics were made in a group of 2,197 men aged 71 to 93 years of age, men with the highest blood levels of estradiol had a 2.2-fold greater risk of stroke, compared with those whose estradiol levels were lower. www .ncbi.nlm.nih.gov/pubmed/17310026

2) Increases carotid artery thickness.
In a study of 313 men whose average age was 58, carotid artery intima-media thickness was measured at baseline and then three years later. After adjusting for other confounding risk factors, higher levels of estradiol were associated with thickening of the carotid artery wall. Researchers concluded, “Circulating estradiol is a predictor of progression of carotid artery intima-media thickness in middle-aged men.” jcem.endojournals.org/content/91/11/4433.full

3) Negatively affects lipids and other risk factors for CAD.
In an angiographic trial of coronary atherosclerosis in a group of men with stable coronary artery disease, significant positive correlations between estradiol levels and other known atherosclerotic risk factors was observed. Researchers concluded, “Our results indicate a possible role of estradiol in promoting the development of atherogenic lipid milieu in men with coronary artery disease.” ncbi.nlm.nih.gov/pubmed/15860391

4) Promotes coronary atherosclerosis.
In another angiographic trial of coronary atherosclerosis in men aged 40-60 years, compared with healthy age-matched controls, men with coronary atherosclerosis had higher levels of estrone and a low level of testosterone in the presence of a high level of estradiol. Researchers concluded, “Low levels of total testosterone, testosterone/estradiol ratio and free androgen index and higher levels of estrone in men with coronary artery disease appear together with many features of metabolic syndrome and may be involved in the pathogenesis of coronary atherosclerosis.”
ncbi.nlm.nih.gov/pubmed/15669538

5) Associated with heart attacks.
In a study of men having suffered an acute myocardial infarction (heart attack), a prior heart attack, and patients with normal coronary arteries, the results showed significantly higher levels of estradiol in both groups of heart attack patients compared with those without coronary disease. ncbi.nlm.nih.gov/pubmed/17435665

6) Increases Blood Pressure
Excessively high levels of estrogen cause production of superoxide, a potent free radical which damages cell structures and increases blood pressure.
ncbi.nlm.nih.gov/pubmed/21411770

[BlueWaffle21]

Was actually going to just message you instead of posting on here, figured you would have something. Thanks!!

[MuscleScience]

I wouldn't even worry about your MD buddies and changing their minds. They don't have time or the drive to read the scientific literature. Most go by what they learned in school and what is in the standard of care for a certain condition. It takes years to change methodology.

[AD]

effects of estrogen in females are very different from effects of estro in men. it wouldn't be totally false to say that estro is cardio-protective in premenopausal women. but clearly equally high estro in men will have a totally different effect.

[BlueWaffle21]

Trying to tell them this but they are taught by older Doctors and this seems to be a newer way of thinking. One of them is open to the idea if I can show some valid proof and the other just laughs every time I bring it up.

[kelkel]

One more for good measure...


http://www.lef.org/magazine/mag2008/...ng-Male_01.htm

[MickeyKnox]

One more for good measure...


http://www.lef.org/magazine/mag2008/...ng-Male_01.htm

One of the best articles on Estrogen, if you ask me. Its my favorite.