Are orals really that toxic???
A very interesting article I stumbled upon that you guys may want to read.
Anabolic steroid-induced hepatotoxicity: Is it overstated?
Clin J Sport Med 1999 Jan;9(1):34-9 (ISSN: 1050-642X)
Dickerman RD; Pertusi RM; Zachariah NY; Dufour DR; McConathy WJ
The Department of Biomedical Science, University of North Texas Health Science Center, Fort Worth 76107-2699, USA.
OBJECTIVE: There have been numerous reports of hepatic dysfunction secondary to anabolic steroid use based on elevated levels of serum aminotransferases. This study was conducted to distinguish between serum aminotransaminase elevations secondary to intense resistance training and anabolic steroid-induced hepatotoxicity in elite bodybuilders.
DESIGN: This was a case-control study of serum chemistry profiles from bodybuilders using and not using anabolic steroids with comparisons to a cohort of medical students and patients with hepatitis.
PARTICIPANTS: The participants were bodybuilders taking self-directed regimens of anabolic steroids (n = 15) and bodybuilders not taking steroids (n = 10). Blood chemistry profiles from patients with viral hepatitis (n = 49) and exercising and nonexercising medical students (592) were used as controls.
MAIN OUTCOME MEASURES: The focus in blood chemistry profiles was aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltranspeptidase (GGT), and creatine kinase (CK) levels.
RESULTS: In both groups of bodybuilders, CK, AST, and ALT were elevated, whereas GGT remained in the normal range. In contrast, patients with hepatitis had elevations of all three enzymes: ALT, AST, and GGT. Creatine kinase (CK) was elevated in all exercising groups. Patients with hepatitis were the only group in which a correlation was found between aminotransferases and GGT.
CONCLUSION: Prior reports of anabolic steroid-induced hepatotoxicity based on elevated aminotransferase levels may have been overstated, because no exercising subjects, including steroid users, demonstrated hepatic dysfunction based on GGT levels. Such reports may have misled the medical community to emphasize steroid-induced hepatotoxicity when interpreting elevated aminotransferase levels and disregard muscle damage. For these reasons, when evaluating hepatic function in cases of anabolic steroid therapy or abuse, CK and GGT levels should be considered in addition to ALT and AST levels as essential elements of the assessment.
Reading What's Not There?
Quote:
Originally posted by eradikate
my friend is going to take methyl test and i heard it's very hard on the liver. by reading the article, i guess it won't hit him that hard eh . . .
And do, pray tell, show us where you found anything about methyltest in the article, which delat generally with AS.
It is well known that oral test is more liver-toxic than injectable test. In other words, any AS can cause hepatic dysfunction, but oral test tends to cause it more. Moreover, according to the American Assn. of Clinical Endocrinologists, oral test tends to result in a higher incidence of high LDL (bad cholesterol) and lowered HDL (good cholesterol).
I suggest that your buddy does a little more research before he plays with this one.
Nothing . . . so to speak.
Let me make the grammar clear. It doesn't mean that I wouldn't reommend anything, it means that I would recommend nothing.
I wish I could give you better feedback, eradikate, but I don't have a picture of your buddy (except that he's stubborn, which makes him as human as the rest of us). Other than knowing that he's 5'10" and 155 lbs. - and that leaves a puzzle with a lot of missing pieces. His age is a key factor, although you've given a clue by using the term kid to describe him. Plus the usual other stuff - any underlying medical conditions, developmental issues, medications, his dietary picture, his current workout routine, etc.
There are two other factors that are important here. One is that you are the one making the inquiry, not him. The good news is that he has a friend who cares (that's you, bro). The bad news is that he doesn't have the motivation to do his own research, which is an indication that he's either uninterested or lazy. When it comes to doing AS, however, the "do-er" has to be self-motivated to take control as a pro-active participant. If they don't care enough to initiate their own research and they're stubborn if you try to tell them anything, it's like talking to a wall. And in that sense, bro, I know your frustration well.
The other factor is an old truth that applies to any situation. You get what you pay for. Just as you're gonna get a better sound with a Fender Stratocaster than you are with a cheap guitar hanging from the pegboard at a K-Mart, you're gonna get less results from methyltest than you are from the good stuff. Does he want to do a quality cycle? Then let him save up and use quality gear. Because using cheap crap can do more harm than good.
If your friend is young (and, since you're 19, I assume he's fairly close in age), you know the rap: most of us are likely to tell him that he's too young to be doing AS. As you know, in many cases, that does not stop young guys from doing AS anyway. So then we have to move to the next goal: To encourage him to do as much research as possible. It's quite clear that he hasn't done it yet, especially if he's taking the word of the friendly neighborhood, um, merchant. (Factor number three, also relevant to everything from AS to used cars: Never take the word of someone whose ultimate goal is to make the sale.)
I would encourage him to become proactive and, if he's computer literate at all, check out this board himself. He'll find that there's a wealth of information - enough to add up to information overload - but it may underscore the fact that he has a lot of learning to do before he takes that first shot or pill. And the learning will pay off, because his ultimate gains will be that much more effective than if he goes into it half-assed.
Remember, as well, that we don't specialize in scare tactics here. (This is not Reefer Madness, a classic cult flick that's well worth watching if you can find it.) Granted, methyl test can have negative efects, but that does not mean that it will have negative effects. The issue is not only the risk factor, which is quite real, but the fact that methyl test is not an effective, efficient way to reach his goals.
My recommendation: Tell your buddy to hang out here for a while, so some major surfing in the drug profiles, and get to know the search function on the threads. He'll be among friends. Because when it comes to achieving your goals, with or without AS, knowledge is power.
(Yaaaas! Everybody say, "Amen!" Now let's go kick some ass!)
Yeah stuff sure is over rated, as far as toxins effects are concerned
:hello: ALL. Being a past excessive cocaine, mdma, user etc ive sorted it and invested in getting fit again and feeling gr8, nearly all drugs are over rated, yet we all deal different and tolerate different quantities. My livers daddy and i put some serious crap through that daily since i was 16, however some livers vary to the next, 1/10 are highly sensitive to mdma ecstacy for example, because they dont have an enzyme present in there liver thats responsible for fighting of the toxins and breaks mdma down. If your born that way and take to much, could mean caput. I know of people that reacted in this way and know of nobody thats died. Ive taken 500 pills in 7 months and im fine, hurt my hear for a while but so has the drink, if not more so. Out of 1000000 that abuse alcohol 646 die, now guess whats in the papers more? ---> ecstasy is. How many out of a million die from ecstasy, hmmmm, in the uk 7/1000000 and in the usa as low as 1/1000000 cos ur stuff tends to be half as strong. All ****e properganda, about illict drugs, steroids, nyaaaaaaaaa :elephant: im hunry :banana: sweet azzz. Sure this all applies to roids 2, Meaoooowwwwwwwwwwwwwwwwwwwwwwwwwwwwww. Ps any advice on using winstrol, dianabol in a cycle alone+Nov,clomid etc, thanks, Im sorry, stupid post, its 3am im bored and have no life bye bye