Originally Posted by
NotSmall
Yeah Maxtiter on ukiron is some kind of russian doctor - he blows my mind with some of the stuff he comes out with and he made a very strong case for the use of long acting slin, initially he favoured levemir/detemir (another long acting slin) but then he dug out some more research that seems to indicate that glargine slin i.e. lantus has 30 times the effect on IGF-1 receptors that levemir has and therefore should be ALOT more effective at building muscle.
"It is still controversially discussed whether insulin triggers mitogenic effects through its own receptor, by interacting with IGF-1R or by activating insulin/IGF-1 hybrid receptors (Eckel, 2005).
In the light of these discussions, the structural changes of the insulin molecule to create rapid- or long-acting insulin analogues become increasingly important. It is known that modifications in the B10 and B26-B30 region are able to change the affinity towards the IGF-1R (Slieker et al., 1997). This has been demonstrated for AspB10 insulin which is known for its strong tumourigenic action (Drejer, 1992). Studies investigating receptor binding properties of insulin analogues have shown that AspB10 insulin and insulin glargine have a 6 to 8-fold and insulin lispro a 1.5-fold higher affinity to the IGF-1R compared with regular insulin (Kurtzhals et al., 2000), while insulin aspart (Bornfeldt et al., 1991) and insulin glulisine (Ciaraldi et al., 2005; Rakatzi et al., 2003a) have a low affinity to the IGF-1R similar to regular insulin. For insulin detemir a 5-fold lower affinity to the IGF-1R has been found (Kurtzhals et al., 2000)."
He advocates a working up to a dose of around 30ius of lantus with breakfast which will work all day and people do not seem to have any hypo problems because it does not lower blood sugar as quickly as the faster acting slins, it should just mean that you are soaking up every last bit of nutrition all day long!
I just want to pack on some serious lean mass before cutting again - I couldn't put a number on it as I have never done a short high dose cycle like this before so I do not really know what to expect.