Should we be concerned that we are using just one isoform of HGH?
The body usually has a pretty good reason for doing things the way it does, so that makes me a little concerned that we are supplying our bodies with just one isoform, albeit the most common form produced by the body (21% according to one paper, and 87% according to another, which is confusing. See below).
With around 100 isoforms produced by the body, and their exact functions still unknown, it seems potentially dangerous to shut down production of the other isoforms in favour of the one.
Stuff like this just makes me wish I could stimulate my endogenous production to the levels I desire instead of pinning HGH. Is that achievable yet?
Any docs care to chime in?
Related articles:
Exercise modulation of growth hormone isoforms: current knowledge and future directions for the exercise endocrinologist (mentions around 100 isoforms)
Proteomics analysis of growth hormone isoforms in... [Proteomics. 2005] - PubMed - NCBI (mentions 24 isoforms)