Thymosin Beta 4 (aka TB4, TB-500) log - Tendonitis, Bursitis

[Anonona]

Hello,

I've had a niggling issue with my knee for two years which has had me out of action for 9 months now. After months of research I decided to try TB4. First time running anything like this and first time self administering with a pin.

Diagnosis from the sports med specialist and physio after an MRI was tendonitis and chronic patellar and prepatellar bursitis.
Throughout this run I'll be continuing with my second round of physio.

As a bench mark, if I walk down a hill- pain and swelling; if I squat- leg gives out, pain, swelling; also can't run.

Protocol as follows

Week 1: 5mg E3D
Weeks 2-12: 5mg once per week
Maintenance: 5mg per month

Day one
Managed to pin subQ without issue, experienced a hot flush for a couple of hours afterwards. Didn't expect the hot flush.
Mixed one 5mg vial with .6ml sterile injecting water. Disposed of remaining water.(bought in bulk). Pinned in the belly.

Cheers,

[jimmyinkedup]

Ill be following!

[Red Bastard]

I get that hot flush, with a feeling of pressure in my neck and face, within a minute. You're the only other person that has mentioned it...

[Anonona]

I get that hot flush, with a feeling of pressure in my neck and face, within a minute. You're the only other person that has mentioned it...

I know of someone(personally) who has reported it, there are also numbers people on the WWW that ask about it and have few responses. It's either a difference in batch (produced with a vasodilator and not properly cleaned) or TB4 is a vasodilator or we got GHRP-6. I discussed it with someone who is doing his PhD on proteins etc.

Note: Experienced less pain at lunch time than I did this morning, also has less pain when active this evening, I believe the TB4 may have had a mild anti-inflammatory effect. Unlikely to be placebo (long story)

[Red Bastard]

Certainly does have an anti inflammatory effect, which can fool some into thinking that the healing is happening faster than it really is.

[diabeticknowledge]

well tb-500 is marketed for research purposes on animals right? why not try to get the good stuff - hgh

[Times Roman]

I've used TB before and cycled it several times. great stuff. never experienced the flushing though. I would get the flush with other peps, like ghrp, (then the hunger), but not TB.

Good luck!
---Roman

[Times Roman]

well tb-500 is marketed for research purposes on animals right? why not try to get the good stuff - hgh

risk of bogus purchasing on line for HGH is VERY high. over 90% is bogus. and it is expensive.

never heard of bogus TB before. and much less expensive.

[Anonona]

Certainly does have an anti inflammatory effect, which can fool some into thinking that the healing is happening faster than it really is.

Which is why I am leveraging that effect to allow me to do physio, whilst also planning a long maintenance plan.

I'll be clear, I'm not looking for a miracle, just the best environment for the best possible recovery.

[bass]

me to, no weird sides from TB, just didn't do much for me, probably due to severe injuries.

[Anonona]

well tb-500 is marketed for research purposes on animals right? why not try to get the good stuff - hgh

Perhaps I am ignorant as I am new to this, could you please enlighten me as to the benefits of HGH?
My understanding is that HGH increases IGF-1 levels, therefore, if I were to pursue increase healing ability via HGH my research subject would be better off receiving IGF-1.

If I were to test IGF-1 in my research subject I would expect to see an increase in collagen type III synthesis that is greater than collagen type I synthesis. My understanding is that collagen type I synthesis and cross linking are the aims of repairing tendons etc.

That said, my understanding is that my research is best targeted at TB4 as this is used primarily for healing, bodies produce it for this purpose and if you look at research by those such as Dr Daniel Morris(he specialises in neurological research at Henry Ford) it is proven to have a positive effect on recovery from neurological and other injuries.

PubMed is your friend.

Cheers,

[jimmyinkedup]

well tb-500 is marketed for research purposes on animals right? why not try to get the good stuff - hgh

Totally different mechanism of action making tb500 worthwhile on its own of even combined with hgh.

[Anonona]

Pinned 5mg, next dose will be in 7 days and repeated every 7 days for a further 5 doses at which point I will reassess progress.

Noticed a decrease of inflammation.

[Anonona]

me to, no weird sides from TB, just didn't do much for me, probably due to severe injuries.

How bad? What was your protocol? Tried IGF-1?

[Anonona]

I've noticed the anti-inflammatory effects have died off around 72hrs after dosing, thinking I will split my doses(5mg/2=2.5mg twice per week). Not sure if anyone has posted a shelf life once reconstituted with sterile water? Need 3-4 days in the fridge.

Note: I can't take any cortisone(injections) or NSAIDs so I am relying on this to allow me to do my physio.

[Times Roman]

also consider MSM. I've written about it many times. i've used for over 15 years. very inexpensive.

[Juced_porkchop]

risk of bogus purchasing on line for HGH is VERY high. over 90% is bogus. and it is expensive.

never heard of bogus TB before. and much less expensive.

agreed!

[Juced_porkchop]

Thanks for the log! I been researching TB500 for a lil while now. would love ANY info you have on your exp with it!Thanks for posting!

[Anonona]

Have noticed more inflammation although this could be due to increased use of the knee. Inflammation doesn't seem to last as long. Skipped PT this week due to work load, have been doing the mobility and ITB work most days.

Pinned 5MG subQ, all looked okay until I nicked an old, deep scar and made a bit of a mess, don't believe I missed a significant amount of the dose. I have a large amount of scarring due to a near death experience.

I will be continuing on the protocol in my first post. I believe this is of benefit for my injury and inability to take NSAIDs, I am more active than I could be before I started on it.

Cheers,

[Anonona]

I was on a trampoline yesterday and survived.
I couldn't squat a month ago, even a bar.
Today I squatted 60% of what I could do 6months ago, but after 6 months off it was my general strength not my knee that was the issue. This is a big win and I will keep loading up plates on each session to see where my knee is at.
My deads are now only down 30%
Overhead pressing movements are still down maybe 20%

Seems to me this is working to keep the injury under control which allows the PT to help prevent re-injury. With me having less impact from injury I have been able to resume training after an extensive hiatus and these strength losses are expected due to length of time off.

I'll keep the log going on dose days, but it would appear to be of benefit to me, someone who couldn't take NSAIDs or similar for PT.

Cheers,

[Anonona]

I've changed to using 1ml to recon and then pin 0.5ml x2, one each side of gut. Less wastage from the vial.
No noticeable hot flush today although ambient temp was quite high, went on to consume alcohol for 12hrs so let's ignore that.

Noticeable increase in pain past 24hrs, I attribute this to the half life of the TB4 (anti inflammatory) and me pushing my knee further. Pain is still less than pre-first dose.

Not much else to report as last post covers most of it.

Cheers,

[Anonona]

Dosed without issue.

I've been quite sick and haven't pushed myself as hard, few light treks etc. In general I am returning more to my normal lifestyle and listening to the mild pain as to progression rates.

Haven't been back to the physio although have been doing the exercises. Not experiencing the post exercise swelling in the knee that I was, also no longer elevating or icing it. That's a big win.

Will follow my plan for dosing.

Cheers,

[bass]

How bad? What was your protocol? Tried IGF-1?

my shoulder injury has a small full tear on one of the tendons, but according to recent CAD Scan I have a bulge where one tendon moves through, and that's where the pain is coming from, and that explains what TB500 didn't work for me. my IGF-1 is very high as is due to TRT, if IGF-1 has any effect to my problem I am sure it would have improved it. good luck on your TB cycle, I hope it works for you as it has worked for so many.

[krask028]

Interested in seeing how things progress for you, Anon. I had surgery to repair a torn labrum approx. 2 months ago and found out about TB-500 and it has really piqued my interest. Anything that can even slightly reduce injury/surgery recovery time is worth it, in my opinion. Also not to derail the thread, but is there anyone out there who had a labrum, or even rotor cuff surgery, that has used TB-500 with success? Either way, I'll be following this log.

[dst_Rick]

Anon/Krask,

I've been on and off this site for almost 2 years, mostly learning. I've ran 3 cycles and had planned on running another after the holidays, however...was doing heavy (for me...85-90lbs) dumbbells/ mixed with trying to keep up with 23 yrs olds playing indoor arena softball...injured my right shoulder-rotator cuff. The bicep attachment is torn and needs to be anchored, the aft one as well. don't know its name...it just hurts like a (&^*^(.

Did one round of cortisone shot, worked miracles in literally 3 minutes...wore off in 3 months, now in pain most of the time and can't sleep with out taking 2 Advil PM's and a hydrocodone before bed.

Surgery is Feb 6th. I'm looking for something (like maybe TB500) that will assist with the healing process.

So, I too am wondering if this will work ??

Shout out--- Times Roman- if you're reading this, we met in the forum while we were in Afghanistan ! Still using your info brother. Best to you !

[Anonona]

Anon/Krask,

I've been on and off this site for almost 2 years, mostly learning. I've ran 3 cycles and had planned on running another after the holidays, however...was doing heavy (for me...85-90lbs) dumbbells/ mixed with trying to keep up with 23 yrs olds playing indoor arena softball...injured my right shoulder-rotator cuff. The bicep attachment is torn and needs to be anchored, the aft one as well. don't know its name...it just hurts like a (&^*^(.

Did one round of cortisone shot, worked miracles in literally 3 minutes...wore off in 3 months, now in pain most of the time and can't sleep with out taking 2 Advil PM's and a hydrocodone before bed.

Surgery is Feb 6th. I'm looking for something (like maybe TB500) that will assist with the healing process.

So, I too am wondering if this will work ??

Shout out--- Times Roman- if you're reading this, we met in the forum while we were in Afghanistan ! Still using your info brother. Best to you !

My injury wasn't as severe. TB4 DID however provide me anti-inflammatory relief above what ibuprofen did.

[Anonona]

[This is yesterdays post.]

Pinned yesterday without issue. I believe the injury is under control and it is just a gradual process of correcting the patellar tracking to prevent re-injury or flare up of healing conditions.

Have been walking a few miles per day most days for the past week which hasn't helped things but compared to a month ago it is far improved.

Going to work on quad strength (year off ) then gradually restart my programming hopefully at the end of the protocol.

Cheers,

[raj1]

Anon, where did you get the 5mg vials if you don't mind me asking. I want to try using Tb500, but I cannot decide where to purchase it from. There are a lot of places that sell 2mg, but not many that sell 5mg and I don't want to just blindly pick one and end up throwing money away on a bunk peptide.

[Anonona]

Anon, where did you get the 5mg vials if you don't mind me asking. I want to try using Tb500, but I cannot decide where to purchase it from. There are a lot of places that sell 2mg, but not many that sell 5mg and I don't want to just blindly pick one and end up throwing money away on a bunk peptide.

Have you read the forum rules?

[raj1]

Peptides can be legally bought, you can't ask for sources for illegal anabolic steroids .

[Anonona]

Peptides can be legally bought, you can't ask for sources for illegal anabolic steroids.

Depends where you're from

[Anonona]

Caught up with an old flame yesterday, hadn't seen her since a month or so before I started the run:
- Noted that my hair was far healthier looking (other health issues are bad for it)
- Noted that my skin was more even (I have quite good skin although scarring over my torso etc from the equivalent to burns)

[bass]

Anon, where did you get the 5mg vials if you don't mind me asking. I want to try using Tb500, but I cannot decide where to purchase it from. There are a lot of places that sell 2mg, but not many that sell 5mg and I don't want to just blindly pick one and end up throwing money away on a bunk peptide.

be careful with those who sell 5 mgs vial for dirt cheap. they just water, trust me. to play it safe pay a little more and get it form a reputable source.

[Anonona]

Pinned without issue. Improved as expected.

Moving to fortnightly dosing for one month before monthly dosing.

Cheers,

[Anonona]

Pinned. Reverted to weekly pins.
Having inflammation issues this weekend/week although I have been pushing my bad knee far harder. Going to stay on weekly until it is back to full strength.

I rather spend the cash than risk a flare up.

[Anonona]

[Delayed post, now day 53]

Returning to weekly dosing has brought relief to inflammation. As expected, chronic conditions do take a longer period to heal than acute injuries.

[Times Roman]

Roman's TB-500 log...........

just out of curiosity, what exactly do you mean by your post on #374?

[Anonona]

Roman's TB-500 log...........

just out of curiosity, what exactly do you mean by your post on #374?

Replied with reference to clinical trial.

[Anonona]

[Delayed post, now day 59]

Continued slight improvement. Taking it easy to avoid re-injury.

[Anonona]

Continued weekly dosing.

Week 1 - 5mg, 5mg
Week 2-12 - 5mg

Conclusion: Of benefit to both chronic and acute conditions. Acute conditions were under control within 6 weeks, chronic has taken 12 weeks. Recommend rest and physio throughout the 12 weeks. Attempting to use injured joint too early potentially delayed healing.
In 12 weeks I have had more improvement than in a year of physio and rest. I was unable to climb stairs without pain, now I can.

Will post back in a few months if the issue returns.