Great PubMed study on HCg

[anabolicbruce]

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Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression.

Coviello AD, Matsumoto AM, Bremner WJ, Herbst KL, Amory JK, Anawalt BD, Sutton PR, Wright WW, Brown TR, Yan X, Zirkin BR, Jarow JP.

Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA. [email protected]

In previous studies of testicular biopsy tissue from healthy men, intratesticular testosterone (ITT) has been shown to be much higher than serum testosterone (T), suggesting that high ITT is needed relative to serum T for normal spermatogenesis in men. However, the quantitative relationship between ITT and spermatogenesis is not known. To begin to address this issue experimentally, we determined the dose-response relationship between human chorionic gonadotropin (hCG) and ITT to ascertain the minimum dose needed to maintain ITT in the normal range. Twenty-nine men with normal reproductive physiology were randomized to receive 200 mg T enanthate weekly in combination with either s****e placebo or 125, 250, or 500 IU hCG every other day for 3 wk. ITT was assessed in testicular fluid obtained by percutaneous fine needle aspiration at baseline and at the end of treatment. Baseline serum T (14.1 nmol/liter) was 1.2% of ITT (1174 nmol/liter). LH and FSH were profoundly suppressed to 5% and 3% of baseline, respectively, and ITT was suppressed by 94% (1234 to 72 nmol/liter) in the T enanthate/placebo group. ITT increased linearly with increasing hCG dose (P < 0.001). Posttreatment ITT was 25% less than baseline in the 125 IU hCG group, 7% less than baseline in the 250 IU hCG group, and 26% greater than baseline in the 500 IU hCG group. These results demonstrate that relatively low dose hCG maintains ITT within the normal range in healthy men with gonadotropin suppression. Extensions of this study will allow determination of the ITT concentration threshold required to maintain spermatogenesis in man.

There has been a lot of debate regarding the use of HCG during and after cycles. The FEW doctors that are actually well versed in the pharmacology of AAS and TRT at the A4M conferences will tell you that HCg is an intelligent addition to your cycle. The most recent studies have dis-credited the old claim that HCg desensitizes Leydig cells, as long as it is used in physiological doses (under 500iu) and an AI or SERM is used in conjunction. Thought you guys would like this-

BTW, since my doc has me using HCG (250iu bi-weekly) I feel MUCH better during and after my cycles. Apparently there is certain enzymes in the brain stimulated by gonadotropins that elevate mood and well-being.

[hosam4ever]

i always belived that its a gr8 drug

[anabolicbruce]

its cheap too. My balls are actually bigger when I'm "on"! LOL

[hosam4ever]

i always recovered better by using it but now it has been suspended in egypt i even wanna do a cycle but waiting for hcg

[anabolicbruce]

why would they suspend it in Egypt? that sux, you try obtaining some from an american clinic/source. Should be pretty easy to get, even on the black market? I have a scrpt through my dr., cost me like $20/month without insurance.

[hosam4ever]

how can i get it from the us

[anabolicbruce]

I don't know what the legalities are with physician treatment outside your country, but you can check out U.S. HRT clinics and obtain a script. Try one of the board sponsors (Oasis) or search google. You should't pay more than $50 for 10,000 iu vials.