Take Supplemental Zinc with your IGF, get better results.

[Property of Steroid.com]

This is a repost from my Blog Today, from my website:

Taking Zinc with your IGF will produce much better results. Zinc can do two things which we want, when we take it with our IGF.

1. Zinc will decrease IGF-1 binding proteins ability to bind to (and deactivate) IGF-1.

2. Zinc will increase IGF-1 receptor sensitivity to IGF-1.

Here's the abstract:

J Endocrinol. 2004 Feb;180(2):227-46
Zinc partitions IGFs from soluble IGF binding proteins (IGFBP)-5, but not soluble IGFBP-4, to myoblast IGF type 1 receptors.

• McCusker RH,
• Novakofski J.

The Department of Animal Sciences, Laboratory for Developmental Endocrinology, The University of Illinois, Urbana, Illinois 61801, USA. [email protected]
Zinc (Zn(2+)), a multifunctional micronutrient, was recently shown to lower the affinity of cell-associated insulin-like growth factor (IGF) binding protein (IGFBP)-3 and IGFBP-5 for both IGF-I and IGF-II, but to increase the affinity of the cell surface type 1 IGF receptor (IGF-1R) for the same two ligands. However, there is a need for data concerning the effects of Zn(2+) on soluble IGFBPs and the type 2 IGF receptor (IGF-2R). In the current work, we demonstrate that Zn(2+) affects the affinity of IGFBP-5 secreted by myoblasts but not IGFBP-4. Zn(2+), at physiological levels, depressed binding of both IGF-I and IGF-II to IGFBP-5, affecting (125)I-IGF-I more than (125)I-IGF-II. Both (125)I-IGF-I and (125)I-IGF-II bound to high and low affinity sites on IGFBP-5. Zn(2+) converted the high affinity binding sites of IGFBP-5 into low affinity binding sites. An IGF-I analog, (125)I-R(3)-IGF-I, did not bind to the soluble murine IGFBP-5. Zn(2+) also decreased the affinity of the IGF-2R on L6 myoblasts. In contrast, Zn(2+) increased IGF-I, IGF-II and R(3)-IGF-I binding to the IGF-1R by increasing ligand binding affinity on both P(2)A(2a)-LISN and L6 myoblasts. Soluble IGFBP-5 and IGFBP-4 depressed the binding of (125)I-IGF-I and (125)I-IGF-II to the IGF-1R, but did not affect binding of (125)I-R(3)-IGF-I. By depressing the association of the IGFs with soluble IGFBP-5, Zn(2+) partitioned (125)I-IGF-I and (125)I-IGF-II from soluble IGFBP-5 onto cell surface IGF-1Rs. This effect is not seen when soluble L6-derived IGFBP-4 is present in extracellular fluids. We introduce a novel mechanism by which the trace micronutrient Zn(2+) may alter IGF distribution, i.e. Zn(2+) acts to increase IGF-1R binding at the expense of IGF binding to soluble IGFBP-5 and the IGF-2R.

[plenty8]

This is a repost from my Blog Today, from my website:

Taking Zinc with your IGF will produce much better results. Zinc can do two things which we want, when we take it with our IGF.

1. Zinc will decrease IGF-1 binding proteins ability to bind to (and deactivate) IGF-1.

2. Zinc will increase IGF-1 receptor sensitivity to IGF-1.

Here's the abstract:

J Endocrinol. 2004 Feb;180(2):227-46
Zinc partitions IGFs from soluble IGF binding proteins (IGFBP)-5, but not soluble IGFBP-4, to myoblast IGF type 1 receptors.

• McCusker RH,
• Novakofski J.

The Department of Animal Sciences, Laboratory for Developmental Endocrinology, The University of Illinois, Urbana, Illinois 61801, USA. [email protected]
Zinc (Zn(2+)), a multifunctional micronutrient, was recently shown to lower the affinity of cell-associated insulin-like growth factor (IGF) binding protein (IGFBP)-3 and IGFBP-5 for both IGF-I and IGF-II, but to increase the affinity of the cell surface type 1 IGF receptor (IGF-1R) for the same two ligands. However, there is a need for data concerning the effects of Zn(2+) on soluble IGFBPs and the type 2 IGF receptor (IGF-2R). In the current work, we demonstrate that Zn(2+) affects the affinity of IGFBP-5 secreted by myoblasts but not IGFBP-4. Zn(2+), at physiological levels, depressed binding of both IGF-I and IGF-II to IGFBP-5, affecting (125)I-IGF-I more than (125)I-IGF-II. Both (125)I-IGF-I and (125)I-IGF-II bound to high and low affinity sites on IGFBP-5. Zn(2+) converted the high affinity binding sites of IGFBP-5 into low affinity binding sites. An IGF-I analog, (125)I-R(3)-IGF-I, did not bind to the soluble murine IGFBP-5. Zn(2+) also decreased the affinity of the IGF-2R on L6 myoblasts. In contrast, Zn(2+) increased IGF-I, IGF-II and R(3)-IGF-I binding to the IGF-1R by increasing ligand binding affinity on both P(2)A(2a)-LISN and L6 myoblasts. Soluble IGFBP-5 and IGFBP-4 depressed the binding of (125)I-IGF-I and (125)I-IGF-II to the IGF-1R, but did not affect binding of (125)I-R(3)-IGF-I. By depressing the association of the IGFs with soluble IGFBP-5, Zn(2+) partitioned (125)I-IGF-I and (125)I-IGF-II from soluble IGFBP-5 onto cell surface IGF-1Rs. This effect is not seen when soluble L6-derived IGFBP-4 is present in extracellular fluids. We introduce a novel mechanism by which the trace micronutrient Zn(2+) may alter IGF distribution, i.e. Zn(2+) acts to increase IGF-1R binding at the expense of IGF binding to soluble IGFBP-5 and the IGF-2R.

good deal, guess ill keep taking my ZMA's at night!

[goose]

Thanks great post! . Zinc is a very important Supplement in other areas too.When you look deeper into T3 and T4 the main difference between taking t4 and taking t3 is you have no control of the conversion rate of t4 to t3, so it's imparitive that your diet be high in Selenium (200mcg) and zinc (50mg) without selenium and zinc, the enzyme iodothyronine deiodinase cannot do its job of converting t4 to t3. One enzyme that is particularily of interest is adenylate cyclase, this enzyme activates the molecule cyclic adenosine monophosphate (cAMP)supplementing with Coleus Forskolii will help with cAMP. T4 has a slower onset of endogeous shutdown, therefore cycling can be slightly longer without breaking.