tren and gyno

[Tommy12]

I don't understand, I have been doing my research on tren and gyno, and in the sticky it said, tren would not aromitize or convert to estrogen, but I have read on here that it could cause gynocomastia. I took a cycle of test and deca almost 2 years ago, and I got gyno. The only thing I have been able to take since then, is winny only. I am getting little despite my diet and workout regiment, and would like to take some tren, but don't want the gyno with it. I could do letro, but I am very prone to gyno. PLEASE HELP.

[clozto50]

Yes tren can cause especially when doing with test,which is a must.We mix masteron with tren and test to help keep down estrogen.Yes arimidex will work.

[Immortal Soldier]

I don't understand, I have been doing my research on tren and gyno, and in the sticky it said, tren would not aromitize or convert to estrogen, but I have read on here that it could cause gynocomastia. I took a cycle of test and deca almost 2 years ago, and I got gyno. The only thing I have been able to take since then, is winny only. I am getting little despite my diet and workout regiment, and would like to take some tren, but don't want the gyno with it. I could do letro, but I am very prone to gyno. PLEASE HELP.

It is true Tren and Deca do not convert to estrogen, but they can still cause gyno through the progesterone route.

Thus you need to have Caber or Bromo on hand or take it during cycle (if you're susceptible)

Also there is the school of thought that says progesterone gyno cannot work without some estrogen (hence the test you use can convert to estrogen) so taking an AI would in theory stop progesterone from happening. No estrogen means no progesterone gyno.

Personally I would just go with Caber or Bromo (Caber being the better option)

[Tommy12]

what about letro? will it works as well? You can't buy that stuff over the counter can you?

[Immortal Soldier]

what about letro? will it works as well? You can't buy that stuff over the counter can you?

Yes you can use letro and no its not available over the counter. It is a prescription drug.

[Deep_Fried]

I just want to point out the misinformation regarding Cabergoline and Bromocriptine. Both of these compounds are Dopamine agonists, especially the D2 receptor.
Dopamine agonists work at the pituitary D2 receptors to inhibit PROLACTIN secretion, and have nothing to do with controlling PROGESTERONE or PROGESTIN action at the Progesterone receptor (PGRr), as this is the method of action of 19nor compounds such as Deca and Tren.

Controlling Prolactin levels is good if they are elevated and a contributing factor to PRL mediated mammary tissue stimulation.

The truth is that Mammry tissue growth, proliferation and differentiation is controlled by the balance/interaction of all 3 hormones: Estrogen, Progesterone, and Prolactin.


Estrogen is responsible for proliferation of mammry gland tissue. Progesterone is also responsible for branching and growth of lobuloalveolar tissue as well. Prolactin contributes to this as well as the lactogenesis phase of mammary tissue development.

Estrogen is responsible for upregulation of the Progesterone receptor (PGRr), thus keeping E under control will directly limit the footprint that Progesterone can take action on as well. If Prolactin is above normal, lowering it can also contibute beneficially.

On that note, AI such as Arimidex, Aromasin or Letrozole is the best bet when dealing with 19nor compounds as the reduction in E will be advantageous in keeping PGR gyno in check as well.

A SERM such as Nolvadex is a VERY BAD choice when running 19nors. Tamoxifen has been documented in studies in producing the same upregulation of the Progesterone receptor just as Estrogen does via the E2 receptor. Even though it suppresses the majority of E's direct action, the upregulation of PGR receptors is counterproductive to keeping total gyno at bay especially Progestin stimulated gyno.

Hope some of this info is usefull.

Take Care.

[CHUCKYthentic]

this is bringiing up a question that i have been wondering about about for a few weeks now. as Immortal Soldier said here:

Also there is the school of thought that says progesterone gyno cannot work without some estrogen (hence the test you use can convert to estrogen) so taking an AI would in theory stop progesterone from happening. No estrogen means no progesterone gyno.

in my next cycle, im running tren a for the 1st time, starting week 6 of a 12 week cycle aling side test e. if i start adex say week 4 for precautionary reasons, would i even bother buying and/or using caber if i am running an AI that is controlling estrogen build up if prolactin can only be produced through progesterone ?

[Immortal Soldier]

this is bringiing up a question that i have been wondering about about for a few weeks now. as Immortal Soldier said here:

Also there is the school of thought that says progesterone gyno cannot work without some estrogen (hence the test you use can convert to estrogen) so taking an AI would in theory stop progesterone from happening. No estrogen means no progesterone gyno.

in my next cycle, im running tren a for the 1st time, starting week 6 of a 12 week cycle aling side test e. if i start adex say week 4 for precautionary reasons, would i even bother buying and/or using caber if i am running an AI that is controlling estrogen build up if prolactin can only be produced through progesterone ?

If you use an AI, in theory there would be no need for Caber or Bromo since it would prevent progesterone gyno.

I am not sure if prolactin is only produced through progesteron, if it is than the AI would prevent prolactin, if it is not than Caber or bromo will be needed to prevent prolactin.

[CHUCKYthentic]

ya it makes sense

good point tho about not being sure if prolactin can only be produced through progesteron. im gonna try to check that out

[hankdiesel]

Last time ran tren my nipples starting feeling like I was getting very serious gyno. It was worse than any dbol or test or anything I've ever taken. I started taken letro and within days the problem was solved.

[CHUCKYthentic]

good to know hank. ya i personally just dont see why i would use caber if i am going to be controlling my estrogen levels with an AI

[Swifto]

I just want to point out the misinformation regarding Cabergoline and Bromocriptine. Both of these compounds are Dopamine agonists, especially the D2 receptor.
Dopamine agonists work at the pituitary D2 receptors to inhibit PROLACTIN secretion, and have nothing to do with controlling PROGESTERONE or PROGESTIN action at the Progesterone receptor (PGRr), as this is the method of action of 19nor compounds such as Deca and Tren.

Controlling Prolactin levels is good if they are elevated and a contributing factor to PRL mediated mammary tissue stimulation.

The truth is that Mammry tissue growth, proliferation and differentiation is controlled by the balance/interaction of all 3 hormones: Estrogen, Progesterone, and Prolactin.


Estrogen is responsible for proliferation of mammry gland tissue. Progesterone is also responsible for branching and growth of lobuloalveolar tissue as well. Prolactin contributes to this as well as the lactogenesis phase of mammary tissue development.

Estrogen is responsible for upregulation of the Progesterone receptor (PGRr), thus keeping E under control will directly limit the footprint that Progesterone can take action on as well. If Prolactin is above normal, lowering it can also contibute beneficially.

On that note, AI such as Arimidex, Aromasin or Letrozole is the best bet when dealing with 19nor compounds as the reduction in E will be advantageous in keeping PGR gyno in check as well.

A SERM such as Nolvadex is a VERY BAD choice when running 19nors. Tamoxifen has been documented in studies in producing the same upregulation of the Progesterone receptor just as Estrogen does via the E2 receptor. Even though it suppresses the majority of E's direct action, the upregulation of PGR receptors is counterproductive to keeping total gyno at bay especially Progestin stimulated gyno.

Hope some of this info is usefull.

Take Care.

Agreed.

Letro/Aromasin (If needed) with Cabergoline on hand.