very confused about HCG

[jfalco]

I'm very confused about how to use HCG for PCT. I've read dosing anywhere from 500 iu to 5000iu.

[johnnybigguns]

What cycle are you thinking about using it with?

[jfalco]

I'm planning on running test e at 500 mg/wk and eq at 600 mg/wk for 12 weeks. For pct I'll run nolva 20 mg/day. I've been told to run HCG at 500 iu/wk from the 3rd week of the cycle until the last test injection. Then I read in the this:

The athlete injects three times 5000 i.u. in a three-day interval. Following, three more injections of 5000 i.u. are injected every five days. After the third HCG injection the intake of Clomid begins since its gonadotropin-stimulating effect in the event of an already activated increased testicular activity is more effective. Clomid is now taken over two weeks, two tablets of 50 mg each per day in the first week and 50 mg tablets per day in the second week.

[johnnybigguns]

You should check out the PCT section on this site and look at the stickies there is good PCTs there.
Have you cycled before?
What is your age/weight/height/bf%

[Coop77]

There are a lot of different opinions about how best to use hCG.

As little as 500 iu every few days is more than enough to replace your body's natural LH/FSH and keep your balls working on cycle. If you don't use hcg during cycle and your balls get shrunken, a larger dose is probably appropriate to bring them back to life.

[jfalco]

So do I understand correctly that if you use HCG while on cycle, then you only need low doses for PCT and if not you need massive doses?

[Mammon]

dont need massive doses anyway.. id stop the HCG before you start any pct meds.

[jfalco]

I'm planning on doing 20 ed nolva for 6 weeks and 25 mg ed aromisin for 3 weeks. Should I also do HCG at 500 iu ed as suggested in the sticky by pinnacle? If so I should do the vitamin e too? Do I just get vitamin e at the health food store. With those legs, I'm sure pinacle knows what he's doing, so I'm thinking why not do exactly what he suggests?

Am I on the right track?

If I start running a low dose of HGC about half way through the cycle, will this affect PCT. It's not really clear in pinnalce's post if he runs any HGC during his cycles.

[Mammon]

Differential effect of single high dose and divided small dose administration of human chorionic gonadotropin on Leydig cell steroidogenic desensitization.

Smals AG, Pieters GF, Boers GH, Raemakers JM, Hermus AR, Benraad TJ, Kloppenborg PW.

This study compared the effect of a single high dose of hCG (1500 IU) with that of the same dose administered in multiple small doses (300 IU, once daily for 5 days) on Leydig cell steroidogenesis. Administration of a single high dose of hCG to seven healthy men raised the mean plasma testosterone (T) level to peak levels 2.1 +/- 0.2 (SEM) X the baseline value at 48 h. Thereafter plasma T decreased to below normal (0.7 +/- 0.1 X baseline) 7 days after the injection. The mean 17-hydroxyprogesterone (17-OHP) level peaked at 24 h (2.5 +/- 0.2 X baseline) and then also fell to a nadir value of 0.6 +/- 0.2 X baseline on day 7. Reflecting the early accumulation of 17-OHP over T, the 17 OHP/T ratio reached its maximum (1.6 +/- 0.1 X baseline) at 24 h at the same time when plasma estradiol [(E2) 4.4 +/- 0.6 X baseline] and the ratio E2/T (2.7 +/- 0.3 X baseline) achieved their maximal values. Administration of 1500 IU hCG in five divided doses of 300 IU daily increased the mean plasma T levels to peak value of 2.1 +/- 0.2 X baseline at 5 days and the levels remained elevated thereafter. The response of T as reflected by the area under the curve was almost twice as great as in the single dose study (2844 +/- 360 vs. 1647 +/- 214). In contrast to the single high dose experiment, mean plasma 17-OHP levels in the divided dose protocol did not peak at 24 h but only gradually increased. As the increase of T exceeded the 17-OHP increase at almost all time intervals, no accumulation of 17-OHP over T occurred as in the single dose experiment. Instead the 17-OHP/T ratio fell to a nadir value of 0.6 +/- 0.1 X baseline on day 7. The initial E2 peak was absent in the divided dose protocol and the E2/T ratio only marginally increased. Considering both experiments together a close relation was found between the hCG-induced increases in E2 and 17-OHP (r = +0.88, P less than 0.001), as well as the ratio 17 OHP/T (r = +0.64, P less than 0.02).

[jfalco]

dont need massive doses anyway.. id stop the HCG before you start any pct meds.

Why?

As I understand HCG is used to kickstart testosterone production. If I use it during my cycle will it prevent testosterone production from shutting down?

[jfalco]

Ok found the thread with the answers I was looking for.