Any update on Myostatin inhibitors?

[quietasamouse]

Hi,

I've been trying to follow the threads on myostatin inhibitors (long story short: the gene that is missing in "Belgian Blue" double-muscled cattle could be potentially regulated in humans using myostatin inhibitors).

Does anyone have any information on where things stand with myostatin inhibitors now?

thanks,

quietasamouse

[Hazard]

ALl i know about them is that there are myostatin inhibitors currently for sale. How well they actually work is beyond me...... the prices are ridiculous......

~Haz~

[Mr.Rose]

There are actual humans walking around with either one or both pairs of myostatin genes terminated. Like the famous child in germany with both terminated. Its the next level in human evolution.

Chemically, i can't find the evidence to support the use of drugs to inhibit myostatin gene expression, but like haz has stated there are plenty on sale, but i wouldn't get to excited.

If you want, you can genetically engineer your sperm so your child is born without one pair, . I kid i kid... but seriously.

[quietasamouse]

Hmmm... I'll have to see if the agricultural crowd is using them. If they are out there, it'll be interesting to see what the intended use is.

[powerliftmike]

There are actual humans walking around with either one or both pairs of myostatin genes terminated. Like the famous child in germany with both terminated. Its the next level in human evolution.

Chemically, i can't find the evidence to support the use of drugs to inhibit myostatin gene expression, but like haz has stated there are plenty on sale, but i wouldn't get to excited.

If you want, you can genetically engineer your sperm so your child is born without one pair, . I kid i kid... but seriously.

I sort of agree along these lines. Drugs can suppress or excite certain receptors but to my knowledge taking a pill to alter your genetic makeup is pretty close to pure crap.

[Mr.Rose]

Yup like i said, i cannot find any evidence to support it.

Also the agricultural industry would not be wasting their money on myo inhibitors, you wont find any info on it. If anything they will be breeding in cattle that already have the gene altered.

[Hazard]

I think the myostatin inhibitors that are being sold are supposed to surpress your body's natural myostatin output..... not turn off the gene.....

I would imagine if they actually did work.... we'd be hearing about them A LOT more......

If someone wants to send me a few thousand dollars i'd be willing to guinea pig it for the board..... bwahahaha

~Haz~

[BIG_GUNS_21]

There are some peptide products that inhibit the out put of myostatin. The good side is that it is suposed to only effect sceletal muscle and not smooth muscle. The bad effects is that its said to drastically weaken connective tissue. So I would think you would get huge and crazy strong...But your joints most likely wont hold out.

[quietasamouse]

Gotcha... was thinking along the lines of chemical inhibition rather than gene-therapy. In a quick trolling it looks as of 2008 folks were still working on it...

Curr Opin Drug Discov Devel. 2008 Jul;11(4):487-94.
Targeting myostatin for therapies against muscle-wasting disorders.
Tsuchida K.

Division for Therapies against Intractable Diseases, Institute for Comprehensive Medical Science (ICMS), Fujita Health University, Toyoake, Aichi 470-1192, Japan.
Abstract
In addition to gene correction therapy and cell transplantation techniques, multidisciplinary approaches to drug discovery and development offer promising therapeutic strategies for intractable genetic muscular disorders including muscular dystrophy. Inhibition of the production and activity of myostatin, a potent growth factor that determines skeletal muscle size, is a novel strategy for the treatment of muscle-wasting disorders such as muscular dystrophy, cachexia and sarcopenia. Myostatin blockers include myostatin-blocking antibodies, myostatin propeptide, follistatin and follistatin-related proteins, soluble myostatin receptors, small interfering RNA and small chemical inhibitors. This review describes the discovery and development of myostatin inhibitors.