As some of you may recall, I recently added a small dose of an Alpha Blocker (Doxazosin) to my twice daily low dose use of a PDE5i (Tadalafil/Cialis) to see if it could enhance the quality of my erections.

I was happy to report that it did just that; in fact, I haven't woken in the morning to a serious erection in a few years (just age related nothing more) and wanted to see what would happen when I added in some AB to the PDE5i use.

My protocol is simple: twice daily (once before bed and again in the afternoon) I take 5mg of Tadalafil (Cialis) and 1mg of Alpha Blocker (Doxazosin). My morning erections have not only come back they are strong and rather impressive. I don't know why we men are so taken by waking erections but we are cause we are men and let me tell you how happy it's made me LOL!

Tadalafil has a long half life (~16 hours) compared to other PDE5i's like Viagra and Levitra (~4 to 6 hours) and it enters the blood stream much faster then the other two as well and is not effected by food intake. Doxazosin has about the same half life as the Tadalafil so by taking them both about every 12 hours assures peak serum levels.

What's this mean you may ask?

It means getting and sustaining a serious erection "on demand" is a shit load easier! Many men get performance anxiety when they take a shorter acting PDE5i like Viagra so it can inhibit the effects of the drug...not the effect men are looking for.

Also, there are very nice health benefits for men as well at these low doses such as lowering BP, reducing the effects of BPH and allowing for a healthy urine stream...among other things.

There have not been many, if at all, studies on the effects of combining a PDE5i with and AB but this study came out recently that seems to confirm what I and other men have discovered when these two compounds are co-administered.

I purchase both Tadalafil and Doxazosin from an online pharmacy at very economic prices so it's not cost prohibitive at all.

So, for some of you guys looking for a more robust erection or where you don't get a strong response to a monotherapy use of a PDE5i the combination of a PDE5i and AB may be just the solution you seek.

Full Study: http://www.nature.com/ijir/journal/v.../3900815a.html

Combined oral therapy with sildenafil and doxazosin for the treament of non-organic erectile dysfunction refractory to sildenafil monotherapy

A F De Rose1, M Giglio1, P Traverso1, P Lantieri2 and G Carmignani1

1Department of Urology, S. Martino Hospital, University of Genoa, Italy

2Department of Medical Statistics, S. Martino Hospital, University of Genoa, Italy

Correspondence to: A F De Rose, Via Donato Somma 77, I-16146, Genova, Italy. E-mail: [email protected]


Abstract

The purpose of this work was to investigate the efficacy and safety of sildenafil in combination with doxazosin for the treatment of non-organic erectile dysfunction in patients who did not respond to sildenafil. We enrolled 28 patients with non-organic erectile dysfunction, for whom 3 months of sildenafil monotherapy had failed. They were divided in two random and homogeneous groups: 14 were treated with doxazosin (4 mg daily) and sildenafil (100 mg 1 h before sexual intercourse); the other 14 patients received sildenafil and placebo. The results were assessed by means of the IIEF questionnaire before the beginning of the study, after 30 days of therapy and after 60 days. Of the 14 patients treated with doxazosin and sildenafil, 11 (78.6%) showed a statistically significant increase of IIEF; in the placebo group, only one patient (7.1%) recorded a significant IIEF increase. The differences observed in the two groups were statistically very significant (P=0.0016). Blood pressure did not show significant alterations. Side effects were minimal and even present during sildenafil monotherapy. The combination therapy with sildenafil and doxazosin resulted in the safe and effective treatment of men with non-organic erectile dysfunction for whom sildenafil alone had failed.

International Journal of Impotence Research (2002) 14, 50-53. DOI: