What is the optimal amount of Arimidex/Anastrozole to take to help LOWER E2 levels?

[killergoalie]

What is the best amount of Arimidex /Anastrozole to use weekly (in equal doses of course) to help LOWER estrogen/estradiol levels to optimal ranges for someone on TRT? And the best time to take it as well please. Along with losing BF of course.

I'm inject 40ml of Testosterone Cypionate SubQ 3x per week, and my total testosterone level is 19.7 nmol/L or 567.7 ng/dl, and my Estradiol level is 327 pmol/L or 89 pg/ml.

Living in B.C. Canada, we cannot get the Sensitive Assay for Males Estradiol test without going to the U.S. and paying through the nose for it, which at this time is not an option for me, so the regular E2 test is all I have to go by. I have been told however, while that is the optimal test, the regular test is sufficient, esp at E2 levels that I have.

I am 53, and have been on TRT since late February of this year.

I also found out recently that my iron level was low (41 ug/L) and have begun supplementation, and it's now up to 68 ug/L.

Also I was diagnosed with severe sleep apnea as my breathing was interrupted an average of 72x per hour, so I've been on C.P.A.P. therapy, and it's really improved my sleeping to where my breathing is now interrupted an average of only 2.5x per hour.

The iron deficiency, and sleep apnea were likely the main cause of my constant tiredness, lack of energy, and feeling of lethargy. I am beginning to feel a bit more energetic, but still not nearly enough.

I am also obese, and realize that I have to lose a lot of weight, which would help lower my E2 level, but with limited energy, that would take far too long, to have an immediate effect on my E2 levels, which need to be lowered A.S.A.P., so any advice on the amount of an A.I. to take, and the optimal time to take it, would be greatly appreciated.

Sorry for all the information, just trying to give as much info as possible in order to help receive the best possible answer.

Thank you in advance.

[TennTarheel]

There are some great threads in this section on AIs. It's not one clear cut answer. Do a quick search so you can see a lot of members' different opinions on it. Good luck bro

Also, reading the Stickies above will give some good insight. Can't ever learn too much!

[killergoalie]

Thanks TeenTarheel. I've read the stickies, and the individual threads on this, and you are correct...very helpful information.

I would just like a bit more specific info on my situation though. I realize that losing weight would be he best all around thing to do for my health, which I am doing, but the time I lose enough bodyfat to have an effect on my E2 levels, I'm afraid they'll be even higher, so I'd like to lower my E2 levels as quickly as possible. Just to get back on a more even playing ground.

[kelkel]

Hey Killer. What is the range on your estradiol test? I really don't know how that level would correlate to a sensitive assay. A consideration may be .25mg twice per week, one day after your first and third injections. Slow and steady wins this race. I don't think I'd go over that dosage without constant monitoring via BW. Also consider B6 as a supplement to help as well.

Good articles below:

http://www.lef.org/magazine/mag2010/...ing-Men_01.htm
http://www.lef.org/magazine/mag2008/...ng-Male_01.htm

[killergoalie]

Hi Kelkel, thanks for the input.

The range on the estradiol test is < 156 pmol/L or < 42.5 pg/ml. I realize that slow and steady wins the race, but my level is so high, I'd like to at least get it down to a reasonable number/level as soon as I can, then taper off the A.I. So I was thinking perhaps .50mg twice a week to start, then after a month or so, get my E2 level checked again, then lower the A.I. to .25mg twice a week. By then, my diet and exercise regimen should be much better, so things should be working together nicely.

There's a local place where I can get Arimidex/Anastrozole in liquigel capsules @ .50mg each, so you can't cut them in half. Or I could try that liquid anastrozole that's available in a neighbouring city.

I'll check out those articles as well.

Thanks again.

[EZ E]

Hi Kelkel, thanks for the input.

The range on the estradiol test is < 156 pmol/L or < 42.5 pg/ml. I realize that slow and steady wins the race, but my level is so high, I'd like to at least get it down to a reasonable number/level as soon as I can, then taper off the A.I. So I was thinking perhaps .50mg twice a week to start, then after a month or so, get my E2 level checked again, then lower the A.I. to .25mg twice a week. By then, my diet and exercise regimen should be much better, so things should be working together nicely.

There's a local place where I can get Arimidex/Anastrozole in liquigel capsules @ .50mg each, so you can't cut them in half. Or I could try that liquid anastrozole that's available in a neighbouring city.

I'll check out those articles as well.

Thanks again.

I would say that is a good plan.

[killergoalie]

Thanks, EZ E! Look forward to starting this hopefully in a couple of weeks.

[kelkel]

Remember with adex it will work pretty much immediately. It does not require a loading phase or time to build up serum levels. Stay on top of your BW with this. Don't crash your E. You can test monthly and it does not require fasting.

[killergoalie]

Thanks again, Kelkel. So even though my E2 level is extremely high, would you recommend I stick with only .25mg of anastrozole/arimidex 2x per week? Or try .5mg 2x per week for a month, get my Estradiol level checked, then lower the A.I. to .25mg twice a week?

I wish Dr.s here in B.C. Canada would be legally allowed to prescribe arimidex for male patients on T.R.T. but unfortunately they're not.

[kelkel]

It's really your call. Split the difference maybe? Two weeks at .5 x 2 per week followed by .25 x 2 for two weeks then retest and titrate accordingly. I'm just cautious as it's easy to crash your E which you really would not appreciate.

Example: Most guys on a cycle, not TRT, will use on average .25mg adex every other day and an average test cycle is 500mg per week. Not counting other stacked items that may aromatize as well. Just wanted to give you some perspective on why I suggested those numbers.

[killergoalie]

Thanks again, Kelkel. Much appreciated.

Just read over on T. Nation that the optimal protocol according to "experts" there, for taking an A.I. such as arimidex/anastrozole is .25mg 3x per week. So if I inject my Test-Cyp on Sunday @ 7 A.M., Tuesday @ 3 P.M., and Thursday @ 11 P.M., that would mean taking .25mg of Anastrozole/Arimidex on Monday @ 7 A.M., Wednesday @ 3 P.M., and Friday @ 11 P.M. for optimal efficiency.

At times I think there is TOO much information out there, where it could begin to get confusing as to which is the best advice/information to use.

[HealthyMan]

Next day seems to be the typical dose time. However, I will let Kel answer since he was asked directly.

[killergoalie]

Next day seems to be the typical dose time. However, I will let Kel answer since he was asked directly.

Oh no prob with answering. I just responded "to" Kelkel, since he responded to me. Just to be courteous. I appreciate your input. All opinions are welcome.

I'm just wondering if 3x per week is better than 2x per week since I inject testosterone 3x per week. Right now my head is about to burst with all the different bits of information about this, and trying to decide which is the optimal method or protocol. With my E2 level so high, I really don't have time to "test" various theories/protocols in order to find the optimal one, which is why I made this thread.

Not meaning to be impatient, but I'd like to get my E2 level down ASAP.

So again, no prob with replying, HealthyinNH. It's all good.

[kelkel]

Healthy chime in as you see fit. That's what it's all about here.

It boils down to this. We all respond differently to AI's and it takes time to dial it in. Example: I inject 60mg twice per week and do not need as AI as my E normally runs around 16-18. I've recently successfully elevated my E by upping my DHEA. Point is, everyone is different.

You are injecting 40mg three times per week I stand by my initial assessment of .5 x 2 per week then dropping it to .25 x 2 and testing in a month. Just because you are injecting 3 times a week does not automatically mean you have to take an AI 3 times per week. You are not going to have large spikes in E injecting that amount. It's not 250mg in one shot, it's 40. Remember, adex has a half life around 46 hrs or so but it does not have to be at peak serum levels 24/7.

When it comes to AI's, less is more and none is best. Do what you have to do to bring it to a level you are happy with and feel good at. LEF recommends a level between 20-30 for males but it is subjective and needs to be based on how you feel (libido, erection quality, joints, etc.) Whatever protocol you choose just be reasonable and check BW in a month and titrate accordingly. You're on top of it and will be just fine!

Kel

[killergoalie]

Healthy chime in as you see fit. That's what it's all about here.

It boils down to this. We all respond differently to AI's and it takes time to dial it in. Example: I inject 60mg twice per week and do not need as AI as my E normally runs around 16-18. I've recently successfully elevated my E by upping my DHEA. Point is, everyone is different.

You are injecting 40mg three times per week I stand by my initial assessment of .5 x 2 per week then dropping it to .25 x 2 and testing in a month. Just because you are injecting 3 times a week does not automatically mean you have to take an AI 3 times per week. You are not going to have large spikes in E injecting that amount. It's not 250mg in one shot, it's 40. Remember, adex has a half life around 46 hrs or so but it does not have to be at peak serum levels 24/7.

When it comes to AI's, less is more and none is best. Do what you have to do to bring it to a level you are happy with and feel good at. LEF recommends a level between 20-30 for males but it is subjective and needs to be based on how you feel (libido, erection quality, joints, etc.) Whatever protocol you choose just be reasonable and check BW in a month and titrate accordingly. You're on top of it and will be just fine!

Kel

Thanks again, Kelkel. I think I'll take you're advice, and go with the 2x @ .50mg for 2 weeks, then 2x @ .25 mg per week, then get some blood work done to check my Testosterone, and Estradiol levels to see how it's going. Much appreciated on the advice. Now just have to get the anastrozole/arimidex LOL!

I wish there was a Dr. in the Vancouver B.C. area who would prescribe it...even off label. But I'll get some somehow.

Thanks again!

[killergoalie]

FINALLY got some Arimidex!! .5mg capsules, so I'm going to take 1 capsule 24 hours after each of my 3 weekly injections of .40 ml of Test-Cyp (SubQ), since Arimidex has a half life of about 46-47 hrs.

My current Estradiol level is 89 pg/ml Range 7.6 - 42.6 pg/ml. I'm going to have more blood work done in a month, so I'll see how well the Arimidex works.

I've also cleaned up my diet, and began regular exercise...weights/cardio, so that should help as well.

[gpetersmarck]

Hey Killer. What is the range on your estradiol test? I really don't know how that level would correlate to a sensitive assay. A consideration may be .25mg twice per week, one day after your first and third injections. Slow and steady wins this race. I don't think I'd go over that dosage without constant monitoring via BW. Also consider B6 as a supplement to help as well.

Good articles below:

Why Estrogen Balance is Critical to Aging Men – Life Extension
Dangers of Excess Estrogen in the Aging Male - Life Extension

As always, this is great input. If I am injecting once per week would I take .5 the day after my injection?

[kelkel]

Day of or day after. Either is fine.
Use caution with adex. Less is more.