4months Igf-1 Des no results

[MrHandsomePants]

I've been doing igf-1 Des for 4 months everyday 5 min preworkout with no gains. At first my dosing was 200mcg then after seeing nothing I upped it to 400mcg and now 800mcg, I've stopped because I didn't notice anything, was my source (nootropic) just bad, or did I desensitize my receptors?

Also on a side note could I inject lactic acid into my muscles to get better and easier gains?

[marcus300]

You wont see results because its all hype and marketing.

[MACKATTACK]

You wont see results because its all hype and marketing.

Was just about to say that. Fork up the cash for real hgh and see the gains and fat loss.

[MrHandsomePants]

There's medical journals that proove the effectiveness of igf-1 des promoting cell hyperplastia, it's not marketing, but I think nootropic source is good for their nootropic products but then they scam the body builders with their peptides, I've recently seen a couple reviews that say their IGF-1 didn't show results like how other sources gave results, the results from nootropic source products were non existent, I spent $500 on their Igf-1 and bcp-157, kinda sucks I didn't specifically look up their reviews on igf-1, my friend got good stuff when he ordered nootropics and I just went for it

[marcus300]

There's medical journals that proove the effectiveness of igf-1 des promoting cell hyperplastia, it's not marketing, but I think nootropic source is good for their nootropic products but then they scam the body builders with their peptides, I've recently seen a couple reviews that say their IGF-1 didn't show results like how other sources gave results, the results from nootropic source products were non existent, I spent $500 on their Igf-1 and bcp-157, kinda sucks I didn't specifically look up their reviews on igf-1, my friend got good stuff when he ordered nootropics and I just went for it

You'll learn by experience but please post the independent medical research to show igf1 des.
Its not worth it trust me or keep trying it but either way you will learn, its all hype and marketing by the pep companies

[MrHandsomePants]

https://www.ncbi.nlm.nih.gov/m/pubmed/1715381/

[Dannyboy51577]

https://www.ncbi.nlm.nih.gov/m/pubmed/1715381/

You are mixing apples and oranges. The type of igf-1 that would be used in nih studies is not what you are buying. I dont dispute that if you injected actual igf-1 of any type that you would see significant results. Problem is you are not injectimg actual igf-1. You are injectimg a diluted peptide containing who knows what.

Last i checked, and this was a while ago, actual igf-1 cost was somewhere near the $1500 per mg. You think you are getting a fraction of that in your peptide? Good luck with that.

I had this argument, spent the money to purchase igf1-lr3 receptor grade, ran it for a month, took bloods - and my igf 1 levels were elevated roughly 4 percent. Which obviously could be due to a ton of different things. Won $500 on the bet that it wasnt worth a shit though

Which is why you didnt get results from the brand you bought, or any other brand. This is simple math man. Figure out the current cost of actual pharma type igf1. Figure out how thin they would have to stretch 1mg to make money. Thats how much igf1 you get in your $100 peptide vial

[Windex]

You are mixing apples and oranges. The type of igf-1 that would be used in nih studies is not what you are buying. I dont dispute that if you injected actual igf-1 of any type that you would see significant results. Problem is you are not injectimg actual igf-1. You are injectimg a diluted peptide containing who knows what.

Last i checked, and this was a while ago, actual igf-1 cost was somewhere near the $1500 per mg. You think you are getting a fraction of that in your peptide? Good luck with that.

I had this argument, spent the money to purchase igf1-lr3 receptor grade, ran it for a month, took bloods - and my igf 1 levels were elevated roughly 4 percent. Which obviously could be due to a ton of different things. Won $500 on the bet that it wasnt worth a shit though

Which is why you didnt get results from the brand you bought, or any other brand. This is simple math man. Figure out the current cost of actual pharma type igf1. Figure out how thin they would have to stretch 1mg to make money. Thats how much igf1 you get in your $100 peptide vial

Exactly this.

For what it's worth, Rich Piana (God Rest) talked about how real IGF-1 cost $1200+ and he stopped using it because it was cheaper to use steroids+HGH with better results.

[marcus300]

You are mixing apples and oranges. The type of igf-1 that would be used in nih studies is not what you are buying. I dont dispute that if you injected actual igf-1 of any type that you would see significant results. Problem is you are not injectimg actual igf-1. You are injectimg a diluted peptide containing who knows what.

Last i checked, and this was a while ago, actual igf-1 cost was somewhere near the $1500 per mg. You think you are getting a fraction of that in your peptide? Good luck with that.

I had this argument, spent the money to purchase igf1-lr3 receptor grade, ran it for a month, took bloods - and my igf 1 levels were elevated roughly 4 percent. Which obviously could be due to a ton of different things. Won $500 on the bet that it wasnt worth a shit though

Which is why you didnt get results from the brand you bought, or any other brand. This is simple math man. Figure out the current cost of actual pharma type igf1. Figure out how thin they would have to stretch 1mg to make money. Thats how much igf1 you get in your $100 peptide vial

That's right ^^
You cant source igf-1 anymore I think last time I saw it for sale the genuine one was about 15 yrs ago and then it was crazy amounts of money. It was stopped and then the whole marketing and hype was pushed for the replacements what really are just a good GDA. I doubt people will stop wasting their money on it because it does read a really good story lol.

[MrHandsomePants]

You are mixing apples and oranges. The type of igf-1 that would be used in nih studies is not what you are buying. I dont dispute that if you injected actual igf-1 of any type that you would see significant results. Problem is you are not injectimg actual igf-1. You are injectimg a diluted peptide containing who knows what.

Last i checked, and this was a while ago, actual igf-1 cost was somewhere near the $1500 per mg. You think you are getting a fraction of that in your peptide? Good luck with that.

I had this argument, spent the money to purchase igf1-lr3 receptor grade, ran it for a month, took bloods - and my igf 1 levels were elevated roughly 4 percent. Which obviously could be due to a ton of different things. Won $500 on the bet that it wasnt worth a shit though

Which is why you didnt get results from the brand you bought, or any other brand. This is simple math man. Figure out the current cost of actual pharma type igf1. Figure out how thin they would have to stretch 1mg to make money. Thats how much igf1 you get in your $100 peptide vial

True, but sometimes pharma super sizes their prices, like with Papaverive, from the pharmacy 1500mgs costs about $760
https://www.drugs.com/price-guide/papaverine
If you were to diy it at home it would be less than $100 for 4500mgs, 2 lbs of katuck is about $47 on Ebay and it has ~4.5g of papaverine, and then extraction materials like citric acid, baking soda, and glass jars might be about $25-30

[MrHandsomePants]

I agree with you guys now though, thx

[lightitup]

Increlex is the real deal that rich piana was speaking on it’s about $1500 and extracted from live E. coli it’s expensive because the disease they made it for is very rare so not a lot of production like other stuff ...most IGF is bunk on the market

[waltr64]

I've been doing igf-1 Des for 4 months everyday 5 min preworkout with no gains. At first my dosing was 200mcg then after seeing nothing I upped it to 400mcg and now 800mcg, I've stopped because I didn't notice anything, was my source (nootropic) just bad, or did I desensitize my receptors?

Also on a side note could I inject lactic acid into my muscles to get better and easier gains?

I have ordered stuff form the same source and it has been good, however with igf-1 from what I have read you need to do it on an empty stomach and not really a pre-workout more to lose bodyfat. I'm older and use HGH so when my doc tested my igf-1 levels I was doing great. For better advice what is your age and have you tried anything else? What kind of gains are you looking for strength, size, fat lose ...?

[Windex]

I have ordered stuff form the same source and it has been good, however with igf-1 from what I have read you need to do it on an empty stomach and not really a pre-workout more to lose bodyfat. I'm older and use HGH so when my doc tested my igf-1 levels I was doing great. For better advice what is your age and have you tried anything else? What kind of gains are you looking for strength, size, fat lose ...?

If you read through this thread you will understand that IGF-1 is a waste of money. If you are already on HGH then that is even more reason than the fact IGF-1 peptide is useless.

[MrHandsomePants]

Hmm, yeah, thx

[GearHeaded]

I have ordered stuff form the same source and it has been good, however with igf-1 from what I have read you need to do it on an empty stomach and not really a pre-workout more to lose bodyfat. I'm older and use HGH so when my doc tested my igf-1 levels I was doing great. For better advice what is your age and have you tried anything else? What kind of gains are you looking for strength, size, fat lose ...?

the reason OP was using it pre-workout is because he was using Igf -DES . the DES form is only active in the body for about 15 mins. he should of been injecting it bi-laterally into the muscle group he was training in the middle of his workout , and not even pre workout . so train biceps for 20 mins, stop your workout and go inject each bicep head , then resume your workout.

taking it randomly on an empty stomach would do nothing . having said that, unless its the real deal it won't do anything either. your way better off spending your $ on gear, HGH, and insulin

[Couchlockd]

Welcome back GH.

[Obs]

the reason OP was using it pre-workout is because he was using Igf -DES . the DES form is only active in the body for about 15 mins. he should of been injecting it bi-laterally into the muscle group he was training in the middle of his workout , and not even pre workout . so train biceps for 20 mins, stop your workout and go inject each bicep head , then resume your workout.

taking it randomly on an empty stomach would do nothing . having said that, unless its the real deal it won't do anything either. your way better off spending your $ on gear, HGH, and insulin

Love your views gh missed you

[Paulpaul]

As stated Increlex (developed by Tercica Incorporated, in Brisbane Caifornia later bought by Ipsen Biopharmaceuticals, Inc.Basking Ridge, NJ 07920 USA) which is the trade name for Mecasermin(rhIGF-1) is available for about $1200/mg.
It's used for kids that wont grow and wont respond to hGH supplementation because they have Primary IGF-1 deficiency disease and or they have Growth Hormone Gene Deletion "who have developed neutralizing antibodies to GH." You could jack these kids on 20IUs of hGH and it would do nothing growth wise as the signaling to produce IGF-1 is absent or have developed chemicals that effectively destroy hGH molecules in the body.

It is dosed at 0.08-0.12mg/kg of bodyweight/twice day. And for it's intended user, children, when injected within 20 minutes must be preceded or followed by a snack or meal. This is to combat the inevitable hypoglycemia be it mild or severe. Ipsen goes so far as to say "Do not give your child INCRELEX® if your child is sick or cannot eat." Of course the manufacturer is obliged to err on the side of caution, especially when dealing with children. But just in case some adult just happens to dose themselves with Increlex(mecasermin) they warn "Severe hypoglycemia may cause unconsciousness, seizures, or death. If you take
INCRELEX®, you should avoid participating in high risk activities (such as driving)
within 2 to 3 hours after INCRELEX® injection, especially at the beginning of
INCRELEX® treatment."
And they give advice on how to treat hypoglycemia. This is great info for any of you who use IGF-1(8-15 hour half-life) and/or the rhIGF-1-LR3 (20-30 hour half life).
You/your child should always have a source of sugar such as orange juice, glucose gel, candy, or milk available in case symptoms of hypoglycemia occur. For severe hypoglycemia, if your child is not responsive and cannot drink sugar-containing fluids, you should give an injection of glucagon.

When using the rhIGF-1-LR3 version, any and all hypoglycemia episodes will require more monitoring(multiple blood glucose level-BGL-tests) and extended treatments ie taking more than a single intake of oral sugars as the half life of the LR3 version is markedly longer than the straight short duration rhIGF-1 (mecasermin). If you are feeling hypoglycemic and then you orally intake an appropriate amount of sugars, your hypoglycemia will have been successfully treated-FOR THE MOMENT. As those sugars are metabolized, the long half-life LR3 version will continue to lower your Blood Glucose Levels(BGL's). If allowed to continue, another bout of hypoglycemia may occur


Rich Piana was on prescribed Vicrin make rhIGF-1 since approx. mid February 2017. Both Increlex and Vicrin are recombinant sources of rhIGF-1(aka mecasermin). Rich's prescription was for 10 micrograms(mcgs.) s/c(subcutaneously), TID(Ter In Die=3 times per day. From the same Florida physician(Dr. Brent J Agin, he was also prescribed Arimidex (anastrozole) at 1mg(milligram), PO(PO=Per Os=by mouth), OD(in Latin =Omne in Die=in English=Once Daily) although Rich reports he was taking one tablet every other day(to confirm-it was prescribed 1 mg EVERY day, he chose to take it every other day) and for a bottle of 30 tablets cost him $290.00 for a cost of US$9.67 per mg including dispensing fees, which is crazy IMO. FYI that pricing was for the Generic anastrozole as well, the generic was substituted out for the prescribed Arimidex. So I can only imagine was the real Arimidex brand would cost, big bucks.
At this point I will note that all literature for both IGF-1 and IGF-1=LR3 products that are produced/marketed by Vicrin carry this tag in BOLD print.
"IGF-1 and LR3 IGF-1 have not been approved by the FDA to treat or diagnose any disease and have not been determined by the FDA to be safe or effective for any use."
Increlex (mecasermin) by Ipsen DOES NOT carry those warnings.

Vicrin also markets an rhIGF1 LR3 product which is basically the peptide hormone IGF-1 with the 3rd protein of the chain, which is a Glutamic Acid amino acid(AA), subbed out for an Arginine amino acid(AA). In addition the Arginine for Glutamic Acid substitution, the LR3 version of IGF-1 also has an extra 13 amino acid(AA) chain added onto it at the "N-Terminus" giving the Peptide Hormone an 83 count of Amino Acids vs. the original IGF-1 count of 70 Amino Acids(AA). The 13 AA chain is as follows "MFPAMPLLSLFVN". In other words, rhIGF-1-LR3 is a lengthened analogue of rhIGF-1.
These 2 changes to the IGF-1 peptide hormone allow for all the original effects of IGF-1, but now the half-life has increased from 8-15 hours for rhIGF-1 up to approx. 20-30 hours for rhIGF-1-LR3. This is advantageous because the LR3 version can now be administered OD(Once Daily) instead of multiple times a day like the straight rhIGF-1 peptide hormone.

Increlex also markets an rhIGF-1/rhIGFBP-3 recombinant human Insulin-like Growth Factor-1/ recombinant human Insulin-like Growth Factor Binding Protein-3 product called Iplex, its chemical name is Mecasermin Rinfabate. It is used for treating Lou Gerhigs disease(amyotraphic lateral sclerosis). This drug has similar actions to Mecasermin(rhIGF-1) but has few sides such as hypoglycemia. This drug was denied for approval in the Eurpoean Union as there were

Increlex(mecasermin) vs. Iplex(mecasermine rinfabate) pricing

"Increlex is priced, on average, at approximately half the cost of the competing IGF-1 replacement therapy. We believe this gives Increlex a strong price advantage with payers, physicians and patients, as they consider their options for the long-term treatment of severe Primary IGFD," said Chris Rivera, senior vice president of commercial operations at Tercica."
He presents the following comparison of pricing between Increlex Mecasermin vs. Iplex Mecasermin Rinfabate.
For example, the annual cost of therapy for a child of:
10kg weight is $12,319 for Increlex compared with $32,850 for IPLEX.
25kg weight this difference is $30,797 vs. $65,700 and at
40kg weight is $49,275 vs $98,550, says Tercica, which said it based its calculations on a multi-use 40mg vial and an average wholesale price per vial of $562,50 for its own product and IPLEX single-use 36mg vial an an average wholesale price of $90.00.

peace
Hog

[lightitup]

Yeh if you really wanna break it down it’s like $110 a IU hollllllly fuck