viti b-6 for gyno ????

[runakid]

i read on one of the meeage board about 2000mg a day of b-6 to stop gyno or was it to reduce fatty tissue that comes with gyno around the nipple area....?? just wanted to be clear on this.. and 2000mg isnt that alot?

[shadyadam]

Never really heard of using b-6 to combat gyno? anyone else on this.

[oldman]

It is good for use when using Deca and you get Progesterone (sp?) gyno. It does not heal or get rid of gyno just the symptoms.. There is nothing other than surgery that will get rid of it 100%.


now 2grams a day is way overkill IMO.. 300 mg a day is good. You do not want to use B6 for extended periods of time either as it can cause nerve damage issues from what I have read..

~Old

[cfiler]

I've never heard of it. I would just stick with nolvadex. That has been proven to help prevent gyno.

[hosam4ever]

b6 @ 200 mg ed to figh t gyno resulted from deca & tren

[Swifto]

It is good for use when using Deca and you get Progesterone (sp?) gyno. It does not heal or get rid of gyno just the symptoms.. There is nothing other than surgery that will get rid of it 100%.


now 2grams a day is way overkill IMO.. 300 mg a day is good. You do not want to use B6 for extended periods of time either as it can cause nerve damage issues from what I have read..

~Old

Wouldnt go over 200mg/ED. Over this and damaging the CNS may begin to occur. Thats the top end. I'd say 100mg/ED then adjust the dose if you wish.

Vit-B6 reduces the amount of progesterone receptors. So, some use it when using Porgestins, such as Deca/Tren. An AI/Vit-b6 is an effective combination at reducing progestenic side effects IMHO.

[oldman]

Wouldnt go over 200mg/ED. Over this and damaging the CNS may begin to occur. Thats the top end. I'd say 100mg/ED then adjust the dose if you wish.

Vit-B6 reduces the amount of progesterone receptors. So, some use it when using Porgestins, such as Deca/Tren. An AI/Vit-b6 is an effective combination at reducing progestenic side effects IMHO.

I normally use 100mg a day but during my last cycle (using deca) I had a few flair ups and bumped to 300mgs. I am sure 200 was enough and I just did overkill. I only used for a few weeks and went back to 100mg for your noted reason.

~Old

[taiotosh7]

DO NOT DO 2000mg that's insane! You will be left with irreversable nerve damage! 200mg max ed, you will also need an equivilent amount of b2 as you need b2 to activate the b6

[ProteinFart]

See here's a very typical situation where research prevails (And more importantly listening to the vets here). I started my Deca/test cyp cycle with Arimidex for some sides including gyno. Well, last week I started to feel a little sensitivity on my nips. How could this happen when I've got my AI? Researched and read EVERYTHING and after a lot of searching, I found a few posts on this board talking about progesterone receptors. I increased my B6 from 100 to 200 ED and BINGO. All is good now

You guys don't get enough credit here. If it weren't for you guys I might have a "Cute little set of Man-boobs" right now!

[oldman]

See here's a very typical situation where research prevails (And more importantly listening to the vets here). I started my Deca/test cyp cycle with Arimidex for some sides including gyno. Well, last week I started to feel a little sensitivity on my nips. How could this happen when I've got my AI? Researched and read EVERYTHING and after a lot of searching, I found a few posts on this board talking about progesterone receptors. I increased my B6 from 100 to 200 ED and BINGO. All is good now

You guys don't get enough credit here. If it weren't for you guys I might have a "Cute little set of Man-boobs" right now!

very good.. yes deca and Tren (which was not sure about) has a different gyno inducing issue than normal and so many people use Deca and don't find this out until it happens.. I was one of them.. I have my B6 ready this time.


~Old

[Swifto]

See here's a very typical situation where research prevails (And more importantly listening to the vets here). I started my Deca/test cyp cycle with Arimidex for some sides including gyno. Well, last week I started to feel a little sensitivity on my nips. How could this happen when I've got my AI? Researched and read EVERYTHING and after a lot of searching, I found a few posts on this board talking about progesterone receptors. I increased my B6 from 100 to 200 ED and BINGO. All is good now

You guys don't get enough credit here. If it weren't for you guys I might have a "Cute little set of Man-boobs" right now!

Like the username...

[marcus300]

Progesterone induced gynecomastia is a myth

[oldman]

Progesterone induced gynecomastia is a myth

then what is it? If it is not gyno what the hell causes the itch and puffyness?


~Old

[Swifto]

Progesterone induced gynecomastia is a myth

HHmm.....Bit contraversal that one Marcus. I'm not agreeing/disagreeing with you. All the information/studies I've ever read have pointed the finger at estrogen though...

[marcus300]

hold on i will try and find what ive read lately

[marcus300]

pheedno QUOTE-

Progesterone induced gynecomastia? Don't think so

--------------------------------------------------------------------------------

I would like to cear up a few misconceptions about progesterone and gynecomastia.

Their is absolutely no steroid that aromatizes into progesterone. The reason for this is that progesteron does not have an aromatic A ring. So toss that myth out the window. Tren? Deca? Sorry but it just doesn't happen.

Now Tren and Deca bind pretty well to the PR. They are progestins in their own right without undergoing any structural changes, but their affinity is MUCH weaker than progesterone itself. Even more so when nandrolone is reduced by 5-alpha reductase into DHN. Their is a small chance of progestogenic activity that could aid in manifesting a mass in the mammry IF estrogen is present in supraphysiological amounts, without proper ratio to testosterone but I have never see a documented case of progestogenic gynecomastia. The reason for this is that the PR has two isoforms. The PR-A and PR-B. PR-B mediates stimulatory effects of progestins; PR-A which is bound with progestins or anti-progestins inhibits PR-B, and PR-A is dominant,. The response to progesterone is determined by the relative expression of the two isoforms.

There is a direct relationship between the PR isoforms and steroid concentrations an this direct relationship suggests high progesterone concentrations, but this will induce the expression of PR-A, which represses transcription of PR-B, which in turn supresses PR function and progestin effect
With initial administration of nandrolone or it's dirivitives, I could see an expression of PR-B but a rapid rise in PR-A will ultimately supress the function of the PR. IMO, you would need a high ratio of the two before concerns, and this is a bit more of a possiblity with the begining of administration. In this time of vulnerability, rest assured in aromatase inhibitors as progesterone is an E2 agonist so the utilization of an AI will help. I personally don't think the concern is warranted though

Their are 4 combinations of hormones that cause gyno- Estrogen, Progesterone, Prolactin, and IGF. Nandrolone is a weak progestin, which agonizes the PRL, it also raises IGF. Progesterone induced gyno is not really of a concern given binding affinity to the PR and the mechanism of the two isoforms. The production of prolactin is a deffinate risk. Not only can it be an inductor for gyno along side estrogen, IGF, and pogesterone; this chance is increased as prolactn lowers testosterone. So you need to make sure to take proper precautions to not only keep estrogen in check, but prolactin as well.

[Swifto]

hold on i will try and find what ive read lately

If its from Pheedno, I've seen it? I've read Hooker state its near enough a myth also. The finger is always pointed at estrogen, not progesterone.

"Concerning progesterone, actually, In some studies it actually has an inhibiting effect on breast cancer growth and tumor development." - Anthony Roberts. Very intresting point.

[marcus300]

If its from Pheedno, I've seen it? I've read Hooker state its near enough a myth also. The finger is always pointed at estrogen, not progesterone.

"Concerning progesterone, actually, In some studies it actually has an inhibiting effect on breast cancer growth and tumor development." - Anthony Roberts. Very intresting point.

Ive seen and read both kind of studies, still reading on this one but just thought id open the discussion abit...

[oldman]

Okay so back to the question what causes the itch and puffy estogen? Why did B6 seem to take care of it? all in our heads?


What is the best anti-e to take on Test/Deca.. I see some peopel say Bromo and others say aromisen (sp?)

~Old

[marcus300]

Okay so back to the question what causes the itch and puffy estogen? Why did B6 seem to take care of it? all in our heads?


What is the best anti-e to take on Test/Deca.. I see some peopel say Bromo and others say aromisen (sp?)

~Old

Id say try all of them and find which one works best for your body, alot react differently.

[oldman]

I used Anastrozole .5mg eod on my last cycle... I ended up getting a little issue with what I noted above.. I added B6 and I Letro (someone told me to use it) and it seemed to clear up.

????? I am still new to it all so not making any factual statements



~Old