eca anti catabolic properties

[lc1987]

how good/bad is the anti catabolic property of eca? i know eca has a half life of 6 hours but if taken 3x daily that would be 18 so i think that's pretty good. iam planning on running eca 3x daily during pct and maybe start cutting and i know that u shouldn't start cutting during pct but i was wondering if eca will help out because of the anti catabollic properties.

[O.M.E.G.A]

antic catabolic?

I dont think that is possibe via the pathways it works through.

however there is no denying its effect on the CNS its ability to suppress appeitite and encourage lipolysis

[lc1987]

yeah man i have read that it has anti catabolic propeties

[perfectbeast2001]

I have read that clen is good to use during PCT as it is "anti catabolic". This was not backed up with any sort of science though!!

[lc1987]

i don't wanna use clen though due to it's long term sides

[Giants11]

There are a few studies that point to ECA being anti-catabolic. Perhaps due to its partitioning effects:

Thermogenic, metabolic, and cardiovascular responses to ephedrine and caffeine in man.

Astrup A, Toubro S.

Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Copenhagen, Denmark.

To develop an appropriate combination of ephedrine and caffeine consisting of clinically relevant doses, we examined the acute thermogenic, metabolic, and cardiovascular effects of different doses of caffeine (C) and ephedrine (E) given separately and in combination to normal subjects. The thermogenic effect after E+C (20 mg/200mg) was larger than that of any other combinations, and E and C exerted a supra-additive synergism on thermogenesis and systolic blood pressure, while being without effect on diastolic blood pressure. The combination also had pronounced effects on glucose metabolism by increasing plasma glucose, insulin and C-peptide concentrations. During chronic treatment the effect of E+C on energy expenditure is maintained, while side effects subside because tolerance develops to its hemodynamic and metabolic effects. During dietary energy restriction E+C promotes fat loss and preserves fat-free mass, which may contribute to its chronic effect on energy balance. In conclusion, the hemodynamic and side effects to E+C are transient during chronic treatment, while the effect on energy expenditure persists. The compound also possesses repartitioning properties, which may be useful in the treatment of obesity.

[Giants11]

Safety and efficacy of long-term treatment with ephedrine, caffeine and an ephedrine/caffeine mixture.

Toubro S, Astrup AV, Breum L, Quaade F.

Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Fredriksberg, Copenhagen, Denmark.

In a randomized, placebo-controlled, double blind study, 180 obese patients were treated by diet (4.2 MJ/day) and either an ephedrine/caffeine combination (20mg/200mg), ephedrine (20mg), caffeine (200mg) or placebo 3 times a day for 24 weeks. 141 patients completed this part of the study. All medication was stopped between week 24-26 in order to catch any withdrawal symptoms. From week 26 to 50, 99 patients completed treatment with the ephedrine/caffeine compound in an open trial design, resulting in a statistically significant (p = 0.02) weight loss of 1.1kg. In another randomized, double-blind, placebo-controlled 8 week study on obese subjects we found the mentioned compound showed lean body mass conserving properties. We conclude that the ephedrine/caffeine combination is effective in improving and maintaining weight loss, further it has lean body mass saving properties. The side effects are minor and transient and no withdrawal symptoms have been found.

[Giants11]

Effects of chronic administration of ephedrine during very-low-calorie diets on energy expenditure, protein metabolism and hormone levels in obese subjects.

Pasquali R, Casimirri F, Melchionda N, Grossi G, Bortoluzzi L, Morselli Labate AM, Stefanini C, Raitano A.

Istituto di Clinica Medica 1, Ospedale S. Orsola, University Alma Mater of Bologna, Italy.

1. We investigated the effects of the chronic administration of a sympathomimetic agent on energy expenditure, protein metabolism and levels of thyroid hormones and catecholamines in 10 obese subjects after a 6-week very-low-calorie-diet programme (1965 kJ, 60 g of protein, 45 g of carbohydrates). L-(-)-Ephedrine hydrochloride (50 mg three times a day by mouth) or placebo were administered during 2-week periods (weeks 2-5 of the VLCD programme) in a randomized, double-blind, cross-over design. Five subjects began with ephedrine and five with placebo. 2. The results were analysed separately in the two groups. No difference was found between them as regards weight loss during the very-low-calorie diet and drug treatments. Conversely, ephedrine therapy induced a significantly lower daily urinary excretion of nitrogen (and, consequently, a better nitrogen balance) with respect to placebo, independently of the drug sequence. Daily urinary levels of 3-methylhistidine during ephedrine and placebo treatments were similar. The fasting resting metabolic rate (oxygen consumption, ml STP/min) fell significantly during the very-low-calorie diet in both groups, but this effect was partially and significantly prevented by administration of ephedrine. Diet therapy significantly reduced 24 h urine levels of vanillylmandelic acid and homovanillic acid, which, however, increased to pretreatment values during ephedrine treatment. No significant effects were shown on 24 h urinary concentrations of adrenaline, noradrenaline and dopamine during the very-low-calorie diet and/or ephedrine treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

[Prada]

Yes both Ephed. and Clen have anti-Catabolic properties albeit, ephed. is not extremely strong. I still feel solid diet and lifting as hard OFF as ON (as possible) in conjucntion with PCT and a stimulant like EC. Is what nonetheless what will determine what you will salvage

[lc1987]

yeah i was wondering if i could use that if i cut during pct cuz i gain some fat during sd cycle. i'm about 14-15% bf right now up from 11-12% bf. so i was wondering if i could cut during pct while on eca due to it's anti catabolic and i will be taking it like 3x a day for a total of 18 hours of half life. if not, i will probably be using clen to cut during pct cuz i really wanna cut out right now for the summer.

[Giants11]

Never cut during PCT. Just wait, ECA will not be strong enough at all the help preserve mass.

[lc1987]

what if i cut halfway through pct?

[Giants11]

Never cut during PCT. Just wait, ECA will not be strong enough at all the help preserve mass.