Alberterol vs Clen debate....comments?

[Tbucket]

Taken from Test Nation, Cy Wilson auth......just curious what some of you vets think about this.....


Albuterol vs Clenbuterol

Q: Some new info about Albuterol has surfaced lately (in one of Doug Kalman's articles at *****) that makes it sound better than Clen. Yet for years, Albuterol was pooh-poohed by the gurus. What's your take?

A: I think in terms of effectiveness, yes, it's better than clenbuterol. However, I still think ephedrine is the best thing to be using for a few reasons.

First, the problem with drugs like clenbuterol is that they actually agonize the beta 2 receptors too well. You see, with beta 2 receptors, they tend to downregulate when bound by a strong agonist. The stronger the beta 2 agonism, the more downregulation. This is why so many guys have discovered that clen is only good for two to three weeks and then seems to lose its effectiveness.

Albuterol is more effective than clen in terms of beta-2 agonism, but this means that it too is only good to use for a short period of time. The reason why I prefer ephedrine is because it not only agonizes beta-2 receptors moderately, thus allowing for prolonged usage, but it also agonizes beta 3 receptors as well. To make it even better, these receptors may up-regulate with continued ephedrine usage.

Not only that, but ephedrine seems to be the better anorectic when compared to clen and albuterol. So, in the long run, ephedrine is the winner, but if you're looking for more of a "quick fix," then albuterol or clenbuterol for two to three weeks prior to whatever event you're preparing for would be the best choice.

[Tbucket]

The Skinny on Clenbuterol

Q: Brock doesn't like clen at all for cutting up. Bill Roberts says it's okay for the last two weeks before a contest. What's your opinion on it, Cy?

A: I agree with both of them. I personally hate clenbuterol. I take one tab, one lousy tab, and I have a terrible headache for three days straight! I just feel like crap. Many others feel the same, but there are those who love it.

As for Bill saying it's okay for the last two weeks before a contest, yes, I agree, using it for a short duration of two to three weeks is all it's really good for. The reason? It causes a dramatic down-regulation of beta 2 adrenoreceptors over a short period time. Thus, because of its potent beta 2 agonism, you experience great results, but only for a short time before your body attenuates to the drug.

I prefer and always have preferred ephedrine for the following reasons: Clenbuterol has been shown to decrease beta 2 receptor content by as much as 45% in only twelve days and, in fact, has been shown to cause down-regulation of these receptors in only 24 hours! In one study, they compared the abilities of ephedrine and albuterol (pretty similar to clenbuterol) to cause down-regulation. Well, albuterol was shown to have nearly twice the rate of down-regulation as ephedrine!

The other obvious reason behind using ephedrine is that it provides a more potent anorectic effect (controls appetite) and has even been shown to increase beta 3 expression. In other words, its efficacy may increase slightly after prolonged usage. The same certainly can't be said for clenbuterol. (2-6)