methylcobalamin question

[ascendant]

well, i have been using cyanocobalamin with fairly decent results for the past couple months. since i saw the methyl on sale during the 4th of july, i bought me a bottle. figured with how some people claim it's more effective than the cyano form and clinical studies have shown conclusive evidence of it in animal testing, i'd try it out for myself.

the one thing i'm wondering is how much to take? i was originally taking 2000mcg/week of the cyano and recently (because i'm a crackhead) bumped it up out of curiosity to 5000mcg/week last week. thinking of taking 2000mcg/week of the methyl with 2 shots weekly, but just wondering if the dosage should remain the same or if for some reason you should use less/more of methyl as opposed to cyano?

[ascendant]

oh, here's some additional info from research done on methyl indicating it's superiority to cyano...

"Methylcobalamin is a co-factor of methionine synthase, an enzyme that transfers methyl groups to homocysteine to regenerate methionine. Elevated homocysteine levels are a risk factor for coronary artery disease. Methionine can be transformed to S-adenoxylmethionine (SAM) that is involved in a variety of methylation reactions in the body, one of which is alleviating depression.

Methylcobalamin also plays a role in cell-mediated and humoral immune function in rats. In vitamin B12 deficient rats, serum C3, IgM and Ig G factors were found to be lower. There was also an elevation of the ratio of CD4+ CD8- to DC4- CD8+, which reduces the ability to fight off pathogens.

Methylcobalamin enhances synaptic transmission in learning and memory. Ikeuchi and associates studied the effects of methyl-B12 on the electrical activity in hippocampal neurons and found that methyl-B12 increased post-synaptic field potential which lasted more than an hour and increased the electrical currents elicited by N-methyl-D-aspartate (NMDA). Cyanocobalamin had no effect.

Methylcobalamin plays a role in modulating human circadian rhythms. It accelerates re-entrainment of the activity rhythm to the environmental light-dark cycle. The suprachiasmatic nucleus (SCN) is involved in relaying photic information to the pineal gland. Methylcobalamin enhanced the field potential in the SCN that lasted an hour. In contrast, cyanocobalamin showed no effect. Methylcobalamin is also required in donating a methyl group for the synthesis of melatonin. Methylcobalamin supplementation can assist in modulating melatonin secretion, enhancing light-sensitivity, normalizing circadian rhythms and improving sleep-wake cycles. Methylcobalamin also helps improve heart rate variability, suggesting that it is involved in balancing sympathetic and parasympathetic nervous system function, perhaps through its involvement with light entrainment and melatonin synthesis.