A study showing resistance to steroids, coactivator defects

[Warrior21]

http://jcem.endojournals.org/cgi/con...ull/84/12/4454

This article talks about 2 chicks who dont respond to androgens. They say that they have steroid acoactivator defects, or androgen revceptor defects. Anyone know more about this?

[guest589745]

I dont think this is your problem though. it says she has signifigantly high cortisol levels, so she was probly a twig.

[guest589745]

If it has something to do with a mutation in the receptor for whatever hormone isnt working, it would make sense that a different compound could work.

[Warrior21]

Have you read about steroid coactivators? I think they are different for each drug. I guess steroids can bind to the nucleus, but won't start gene transciption until they are activated by these coactivators. There are also certain enzymes involved in this.

I'm getting warmer. I'm not anywhere near the solution though. Like I said the more you know, the more you know you don't know shit.

Did you read that these chicks had high cortisol, but they didn't see any effects of high cortisol. The study is valid, they said their androgen levels were higher than mens. They didn't see any virilization from super-androgen levels. It's obviously something wrong in the chain that activates steroids. The problem is that there is so many events which have to take place before steroids work. Its hard to pinpoint it.

[guest589745]

Maybe vitor will post after he finishes, what I am assuming he is doing, reading the study.

[Warrior21]

Theres just so much to this for myself. I'd really appreciate others input. Like you said in the other thread Skull. Most people will not take part in this because they respond to roids. They'd rather tell us our diet and training sucks, and be done with it. Forget learning anything and helping somebody right!

[guest589745]

Yup. But man, I have ADD and reading long ass stories like, makes me angry an shit so, its hard to realy study hard for me. I try though but I get frustrated and have to stop and do something else.

[Warrior21]

You're telling me? I'm luck this stuff interests me. I got ADD too. I grew up with video games.

[Warrior21]

K at this point I'm desperate. Any doctors or med students around? You figure this out whats wrong with me, how to fix it. If you're successful I'll send you a $500 check in the mail. You have a man's word.

[guest589745]

I think they would need more than to speak with you to determien what is up. HAve you thought about going to a doctor for this ?

[Warrior21]

I think they would need more than to speak with you to determien what is up. HAve you thought about going to a doctor for this ?

No doctor wants to see me. I thought about the rejuv clinic guy again but he wants to charge 350 for consult and 800 for bloodwork. You can bet your ass I'm going to need bloodwokr a few times. A doc might be able to help me online through trial and error.

Shit, we can try something new everyday, I can get renbolone with no ester on it. COme to think of it, I may do that. That would speed up my research.

[Warrior21]

Vitor you spend a lot of time on my threads. What do you think? Should I try trenbolone suspension on a daily basis and try different strategies.
The only thing Im afraid of is that if I do have a defective coactivator gene then there is really no hope for me.

At that point I will do IGF-1 LR3/slin cycles. But that shit is just too expensive. I know you guys are going to tell me to give up on roids but I won't go down without a hell of a fight

[guest589745]

I would try running tren/trt or NPP/trt and see what happens, with a moderate dose, then try dht/trt adn see how you react to each one.

[guest589745]

I would also go with fast esters only and get bloodowrk done before, during and after. It shouldnt be very expensive, hell, you can get your insurance to pay for it like me but make sure to tell them yuo are having impotency problems or the ymight not check your test/estrogen levels.

[Warrior21]

Testing for levels of anabolic steroids is expensive. Its not a regular test.

[Iron-man]

Warrior21, what state are you in?

[Warrior21]

FL, why?

[Warrior21]

Taken from a study on PubMed. Basically backs up my theory that steroid coactivators have to do with resistance to roids;

"Expression of steroid receptor coactivator-1 (SRC-1) was associated with nodal positivity (P < 0.05) and resistance to endocrine treatment (P < 0.001). "

[Iron-man]

FL, why?

Well, I know a doc that is cool with aas & versed as well, but unless your in S. Fl, that doesn't really help much. I would have to see if he is interested first though.

[Warrior21]

Well, I know a doc that is cool with aas & versed as well, but unless your in S. Fl, that doesn't really help much. I would have to see if he is interested first though.

I'm 100 miles north of Miami. I want to see him, extremely. Please tell him whatever necessary for him to want to see me. Please. I'll drive to whereever in FL, a couple of tanks of gas don't mean shit at this point.

[Iron-man]

OK, I'll contact him this week & PM you about what he says. Is your PM activated?

[Warrior21]

" Therefore, tamoxifen may exert its effect not by a simple passive mechanism driven principally by competitive receptor antagonism but through the active recruitment of coactivator and corepressor proteins to produce a mixed transcriptional phenotype."

I dunno if I posted in this thread or the other. But Tamoxifen has much to do with steroid coactivators. A dose of 300mg daily was suggested to me to help recruit more coactivators. Without coactivators, transcription will not happen. When transcription dosen't happen, your body will not produce more muscle.

[Warrior21]

OK, I'll contact him this week & PM you about what he says. Is your PM activated?

Yes sir. Thank you man, really.

[guest589745]

interesting. But hasnt it been shown to increase prolactin with 19nors?

[Warrior21]

interesting. But hasnt it been shown to increase prolactin with 19nors?

Prolactin hasn't been mentioned in this studies. Although I keep on finding progesterone articles when I search for steroid coactivators.

Skull, wanna join in on all the fun? I sent you a PM by the way. Of course tell him I sent you please.

[guest589745]

Thanks. Im good though

[Warrior21]

Thanks. Im good though

hehe, I'd be too if I weren't the one whos most fked by this.