gyno!! is it progesterone induced?

[Billytk03z]

first I have searched the threads and found no solid info on it.......


I do not have swollen nipples but a swollen pec... I have been on letro for the past 5 weeks and it hasnt done anything for me..... on my recent blood test my progesterone level came back at the high end of the range..... what can I do to attack this gyno from all levels.... Im on letro, what else can I add to combat the gyno if its progestrone induced....?

[brass-man]

Swollen pec? That doesn't sound like gyno to me.

[C_Bino]

Man I really dont think you have gyno. Honestly I am almost 100% sure you dont. I expressed this to you via PM when it didnt sound like gyno and it still doesnt. Some people just have progesterone on the higher end naturally. And you did say higher END, but its not off the charts or anything I assume.
If you are running letro I really dont think you have anything to worry about. Get some bromo if you are really concerned but my honest opinion is you are worrying about nothing.

What compounds were/are you using?

[Billytk03z]

Man I really dont think you have gyno. Honestly I am almost 100% sure you dont. I expressed this to you via PM when it didnt sound like gyno and it still doesnt. Some people just have progesterone on the higher end naturally. And you did say higher END, but its not off the charts or anything I assume.
If you are running letro I really dont think you have anything to worry about. Get some bromo if you are really concerned but my honest opinion is you are worrying about nothing.

What compounds were/are you using?

Bro, I started my cycle jan 3 (Tbol 60mg and finasteride 1mg) ....... in approximately one week from the start of my cycle my left pec became swollen underneath the nipple.... the right side pec stayed and is still normal.... I squeezed my left nip and a little fluid came out... when I push in around my left pec underneath my nipple I feel these tiny little balls and there is a semi hard lump ball just under the nipple.. again the right side doesnt have this... the nipple isnt bigger/swollen, its just the pec underneath the nipple that is swollen and puffy..... I think this is gyno.. but I dont know if its progesterone or estro induced...... I dont know how much longer I can handle being on letro, my joints are killiing me and my sex drive is taking a beating..... I really need help wit this..... how much bromo would I use?

[Billytk03z]

bump

[theboss]

from Tbol ?

[vitor]

Progesterone gyno will usally result in the puffy nippel syndrom, or an enlargment of the aroeal...Letro will not cure this, I know this can be solved with minor surgery,(areola reduction surgery).

[theboss]

bromo - caber - dostinex - winny .....and some say B6

[C_Bino]

bromo - caber - dostinex - winny .....and some say B6

Caber and dostinex are the exact same thing.

[theboss]

Caber and dostinex are the exact same thing.

yes i know but some people only know them by 1 name so i named both

[Billytk03z]

bromo - caber - dostinex - winny .....and some say B6

do I take these while Im still running letro? and at what doses do I run each one at? I have winny depot right now.... would it be worth while to give that a shot..... I need something cuz my pec is f'in' annoying the hell out of me.. my nipple hasnt gotten bigger, there is a large lump under my nip that runs along the bottom of my pec which makes it look like its swollen... not to mention that i also have discharge when I squeeze my nips.... Damn, what can I do.... is it finasteride thats causing this? what is it?

[Billytk03z]

bump

[SuperK]

I had gyno. It's a lump about the size of a quarter just behind the nipple that hurts when you apply pressure. The only way to get rid of it is to have it surgically removed and believe me that is NOT fun. I had a drainage tube sticking out of my chest for about 10 days, pretty f'en sick. Now I have a scar around the nipple and a lump of scar tissue inside but aleast the nipple looks somewhat normal and not puffy.

[monstermasss]

bro i cant begin to think someone can get gyno from tbol, this would tell ya you better front load some cabergoline before you start next cycle, and add some letro, it would look like this for your currant problem:
letro 2.5mg ed till gone
caber 250-500mcg till gone
raloxifen 60mg ed till gone

this is my personal gyno reduction, as gyno never really goes away, it just hybernates on guys who are prone to it, as i am every cycle and this protocol works for me every time.

[Billytk03z]

theres a lump but no pain or tenderness..... so does that mean its treatable......?

[Billytk03z]

bump

[Snrf]

Growth hormone treatment induces mammary gland hyperplasia in aging primates.

Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892-1770, USA.

The decline of growth hormone (GH) and insulin-like growth factor I (IGF-I) production during aging has been likened to the decrease in gonadal steroids in menopause. The repletion of GH/IGF-I levels in aging individuals is suggested to restore the lean tissue anabolism characteristic of youth. In addition to anabolic effects on musculo-skeletal tissues, GH also stimulates mammary glandular growth in some species, although its effects on primate mammary growth remain unclear.

Some clinical observations implicate GH in human mammary growth, for example, gynecomastia occurs in some children treated with GH (ref. 6), and tall stature and acr*****ly are associated with an increased incidence of breast cancer. To investigate the effects of GH/IGF-I augmentation on mammary tissue in a model relevant to aging humans, we treated aged female rhesus monkeys with GH, IGF-I, GH + IGF-I or saline diluent for 7 weeks. IGF-I treatment was associated with a twofold increase, GH with a three- to fourfold increase, and GH + IGF-I with a four'-to fivefold increase in mammary glandular size and epithelial proliferation index. These mitogenic effects were directly correlated with circulating GH and IGF-I levels, suggesting that either GH or its downstream effector IGF-I stimulates primate mammary epithelial proliferation.
PMID: 9334728 [PubMed - indexed for MEDLINE]

thought it might be of interest

[Billytk03z]

Im wondering if I should stop the hgh and finasteride for awhile and see what happens..........

[Kale]

Here is Pheedno's theory of Progesterone induced Gyno. Comments from the guru's ?

Progesterone induced gynecomastia? Don't think so

I would like to cear up a few misconceptions about progesterone and gynecomastia.

Their is absolutely no steroid that aromatizes into progesterone. The reason for this is that progesteron does not have an aromatic A ring. So toss that myth out the window. Tren? Deca? Sorry but it just doesn't happen.

Now Tren and Deca bind pretty well to the PR. They are progestins in their own right without undergoing any structural changes, but their affinity is MUCH weaker than progesterone itself. Even more so when nandrolone is reduced by 5-alpha reductase into DHN. Their is a small chance of progestogenic activity that could aid in manifesting a mass in the mammry IF estrogen is present in supraphysiological amounts, without proper ratio to testosterone but I have never see a documented case of progestogenic gynecomastia. The reason for this is that the PR has two isoforms. The PR-A and PR-B. PR-B mediates stimulatory effects of progestins; PR-A which is bound with progestins or anti-progestins inhibits PR-B, and PR-A is dominant,. The response to progesterone is determined by the relative expression of the two isoforms.

There is a direct relationship between the PR isoforms and steroid concentrations an this direct relationship suggests high progesterone concentrations, but this will induce the expression of PR-A, which represses transcription of PR-B, which in turn supresses PR function and progestin effect
With initial administration of nandrolone or it's dirivitives, I could see an expression of PR-B but a rapid rise in PR-A will ultimately supress the function of the PR. IMO, you would need a high ratio of the two before concerns, and this is a bit more of a possiblity with the begining of administration. In this time of vulnerability, rest assured in aromatase inhibitors as progesterone is an E2 agonist so the utilization of an AI will help. I personally don't think the concern is warranted though

Their are 4 combinations of hormones that cause gyno- Estrogen, Progesterone, Prolactin, and IGF. Nandrolone is a weak progestin, which agonizes the PRL, it also raises IGF. Progesterone induced gyno is not really of a concern given binding affinity to the PR and the mechanism of the two isoforms. The production of prolactin is a deffinate risk. Not only can it be an inductor for gyno along side estrogen, IGF, and pogesterone; this chance is increased as prolactn lowers testosterone. So you need to make sure to take proper precautions to not only keep estrogen in check, but prolactin as well.

[Snrf]

Im wondering if I should stop the hgh and finasteride for awhile and see what happens..........

I'd give it a go

[Billytk03z]

Thing is..... I started using finasteride at .5mg in the beginning of dec 06 in anticipation of starting my tbol cycle in the beginning of jan 07 (which I did, jan 3rd to be exact).... On jan 3 when I started my tbol (60mg ed) cycle I also bumped up my finasteride from .5 to 1 mg.... Bam!!! In about one week is when I noticed my left pec had become swollen like it is now.... its like one big soft lump with a bunch of little tiny lumps scattered around the left pec area, the right side has none of this.....