Will Running A-Dex clear through cycle hurt your gains?

[YouAintKnow330]

This question is for the dudes that have Ran Arimidex clear through their cycle from day one... Do you think doing this put a dampen on your gains any what so ever at all? I am thinking about running Arimidex at .25 every day when I do my next cycle with sust at 750mgs a week... What do you all think?

[JAY_WD]

This question is for the dudes that have Ran Arimidex clear through their cycle from day one... Do you think doing this put a dampen on your gains any what so ever at all? I am thinking about running Arimidex at .25 every day when I do my next cycle with sust at 750mgs a week... What do you all think?

Personally, i wouldnt run Adex or any other AI whilst on cycle.
It will affect your gains as the aromatization process is necessary for muscle growth.

Merc wrote an awesome thread on this topic. Shoot him a PM for the link or use search button. I think its titled something like Estrogen - Will it affect my gains?

[Von Dutch]

Only run a-dex when you have gyno or bloating problems. A-dex will affect your gains.

[dupa95]

http://forums.steroid.com/showthread.php?t=319202 Please read this articul apreard in muscle and development magazine.

[gixxerboy1]

I always run a low dose to keep some water off. And i'm happy with all my cycles. Who knows would i have gianed an extra pound of muscle if i didnt take it? Dont really care. I'm not watching every once

[ziinus]

If you're very prone to gyno, run letrozole + nolvadex. running nolvadex with letro prevent a lot of problems due to letro ( cholesterol, joint pain, ... )
Some will say i'm a stupid bastard but i tried this many times and it always worked well

[kick6]

a-dex lowers IGF-1 so it will impact your gains.

[ziinus]

Don't think igf-1 is the main culprit

[Merc..]

Don't think igf-1 is the main culprit

Nolva lowers the blood plama levels of type II AI's ( Adex )..


See this study..



Interactions of antioestrogens and aromatase inhibitors.

Schmid P, Possinger K

Department of Oncology and Hematology, Charite Campus Mitte, Humboldt University Berlin, Germany.

Aromatase inhibitors and antioestrogens have shown substantial activity in primary and advanced breast cancer. Since they exhibit different modes of action, attempts have been made to combine them or to use them sequentially in order to potentially increase their efficacy. In preclinical studies, combined, sequential or alternating treatments with aromatase inhibitors and antioestrogens have failed to provide higher antitumoural activity. There are relevant pharmacokinetic interactions resulting in decreased plasma concentrations of third generation aromatase inhibitors when combined with tamoxifen. Several randomised clinical trials comparing single agent and combined treatment with tamoxifen and aminoglutethimide failed to show any benefit for the combination. Early results of the adjuvant ATAC trial indicate that single agent anastrozole is superior to tamoxifen or the combination of both. Several trials are ongoing which might help to further define the role of sequential or combined treatment with aromatase inhibitors and antioestrogens. However, to date, looking at the current evidence, combined treatment with aromatase inhibitors and antioestrogens does not appear to provide additional benefit compared to single agent treatment.


Merc.

[Merc..]

a-dex lowers IGF-1 so it will impact your gains.

Estrogen has been linked to increses in IGF and GH ..

test effects are dependant on the aromatization process..

Adex lowers estro which is the main culprit..



Merc.

[samcam]

I always run a low dose to keep some water off. And i'm happy with all my cycles. Who knows would i have gianed an extra pound of muscle if i didnt take it? Dont really care. I'm not watching every once

I'm with you, always run .25 a-dex and am happy with all my cycles.