Clenbuteral and sedatives

[jg42058p]

I'm on clen right now and I'm also on a sedative called benztropine.

The benztropine was prescribed to me to help with restless leg syndrome (which I have had long before clen).

at first when I took clen without the benztropine I had the jitters all over my body... But when I took the clen WITH benztropine I still have a few jitters but not nearly as much.

I am wondering - does the decrease in tremors mean that the clenbuteral is not as effective? Would the sedative (benztropine) make clen less effective?

[outofthebox]

Uppers and downers at the same time not good...sounds like a good mix for a heart attack, be careful...

[magic32]

WOW, you picked a serious combo, the type that serves as a learning tool…THANKS!

I'm on clen right now and I'm also on a sedative called benztropine.
WHEN DO YOU EXPERIENCE RLS?
AND WHEN DO YOU TAKE BENZ?

IF USED AT OPPOSING TIMES, I.E. CLEN DURING THE DAY AND BENZ AT NIGHT, PROPERLY ADJUSTING THEIR ADMINISTRATION SHOULD GREATLY REDUCE INTERACTIONS.

IF HOWEVER, YOU ALSO REQUIRE BENZ FOR SITTING AND RELAXING, THEN WHILE USING CLEN YOU'D NECESSARILY HAVE TO EXPERIENCE THE DRUG INTERACTION YOU CITED.


The benztropine was prescribed to me to help with restless leg syndrome (which I have had long before clen).

at first when I took clen without the benztropine I had the jitters all over my body...
But when I took the clen WITH benztropine I still have a few jitters but not nearly as much.
YOU'RE DESCRIBING A CLEAR INTERACTION, SOME OF WHICH ARE LISTED BY MERCK:
http://www.merck.com/mmpe/lexicomp/benztropine.html

I am wondering - does the decrease in tremors mean that the clenbuteral is not as effective?
POSSIBLY.
THE SEVERITY OF A DRUG'S SIDE EFFECTS, CAN/MIGHT BE AN INDICATOR OF EFFECT (THAT IT IS WORKING), AND SIMILARLY INDICATIVE OF EFFECTIVENESS (HOW WELL IT’S WORKING). BUT THE INVERSE COULD ALSO BE TRUE IN THAT A DRUG CAN WORK IN THE COMPLETE ABSENCE OF SIDE EFFECTS, OR MAY STILL WORK WELL WITH ONLY MINIMAL SIDES.

Would the sedative (benztropine) make clen less effective?"
POSSIBLY, BUT IN THIS CASE ONLY IF BENZ IS ABSORBED AT, AND PREFERRED BY THE BETA-2 RECEPTOR WHERE CLEN IS ABSORBED, THUS CREATING COMPETITION, OR IF BENZ REDUCED CLEN'S AVAILABILITY.

For more on this, click the above provided Merck link and take special note of “Drug Interactions” specifically at how Benz inversely affects, via gastric degradation, otherwise similar drugs making drug structure the common denominator. Furthermore, under “Mechanism of Action” we see that at least in animal data it works like pyrilamine maleate (a popular veterinary antihistamine) which is good because this family of drugs compliments Beta-agonists like Clen.

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Long story short for the non-chemistry buff, neither appears to significantly reduce the other, but if I had to guess at the relationship I’d say the Benz is augmenting the Clen and that the latter is not influencing (neither positively nor negatively) the former.

[T_Own]

wow that was solid lol. very informative