Testosterone linked to elevated risk of heart attack

[61er]

CBS just reported on new research linking testosterone and elevated risk of heart attacks. A UCLA study of 55,000 men finds the risk of heart attack among men over 65 more than doubled within 90 days of treatment. For men under 65 with a history of heart disease the risk almost triples. Increased clotting of arteries around heart is suspected.

Report notes that 43% of men being treated with testosterone do not actually suffer from low T. CBS has not posted a link yet, but here's one from an NBC affiliate.

[2Sox]

CBS just reported on new research linking testosterone and elevated risk of heart attacks. A UCLA study of 55,000 men finds the risk of heart attack among men over 65 more than doubled within 90 days of treatment. For men under 65 with a history of heart disease the risk almost triples. Increased clotting of arteries around heart is suspected.

Report notes that 43% of men being treated with testosterone do not actually suffer from low T. CBS has not posted a link yet, but here's one from an NBC affiliate.

This seem to be a "cohort study" which is not very scientific. Take a look at this for an explanation:
Cohort study - Wikipedia, the free encyclopedia

Here is a link to the actual study:
PLOS ONE: Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men

The news story references an article in JAMA from this past Novermber and which has been TOTALLY debunked as terribly flawed and careless. I started a thread here about it:

http://forums.steroid.com/hormone-re...mi-stroke.html

I'm disgusted with the media but not surprised. One outlet picks up a story and then it's "monkey see, monkey do" by the other outlets. Investigative reporting? Nonsense. Sensationalism is easier and cheaper.

I'm fairly certain this one will shortly be debunked too.

[kelkel]

Everything 2Sox just said.....

[2Sox]

Here is LowT's answer to the Jama article:

LowTestosterone.com Debunks Latest Long-Term Low Testosterone Study -- HOUSTON, Nov. 8, 2013 /PRNewswire/ --

It will give you an idea of what needs to be done to get it right.

Read that thread. A lot of good stuff was posted.

[61er]

Thanks for the link to the study (published yesterday) and to the earlier discussion board. This is new research, not the debunked research you mentioned.

Here is the CBS Evening News report.

[Low Testosterone]

Nelson Vergel asks for change in testosterone guidelines after another negative study

[17chester6]

I am not an epidemiologist and so I am in no position to critique the above articles. Having said that, in the case of menopausal women who have preexisting heart disease, their rates of adverse cardiovascular events increase if they are started on HRT (estrogen and progesterone). This increased incidence falls off the longer they are on HRT, so it's mostly an effect seen in the early part of HRT usage.

As a corollary, and until proven otherwise, it may be prudent that hypogonadal men with preexisting heart disease be counselled of a possible higher rate of heart attacks etc if they take TRT. It is still a given that the haematoctrit and E2 levels should be tested and treated as is approproiate.

[2Sox]

The horse shit is starting to fly already. I'm fairly certain the TRT community is hard at work with rebuttals. If anyone finds them, please give us all a heads up.

» Is Testosterone Replacement Good or Bad? - GoodRx