
Originally Posted by
Testify
No, I do not have an emergency. I am probably in the minority here, based on several recent threads, but anyway . . . .
As I read through all of the posts about Nolva and Clomid, and their often recommended dual usage, I began to wonder about how they actually work. I have read extensively on the two, but I do not understand the advice that suggests using both at the same time. Are not Nolva and Clomid remarkably similar substances that compete for the same receptor sites? Both are "weak" estrogens that "block" or occupy the estrogen receptors, so that stronger estrogens cannot bind and produce unwanted sides, right? So wouldn't the administration of both drugs simultaneously be a waste - and worse, counterproductive?
Nolva is routinely used to counter aromitization (indirectly, by blocking its action on receptors) during a cycle, and by those who cannot or chose not to use Clomid due to unwanted sides (however misguided these perceptions may be) during PCT. Clomid has the advantage of kickstarting the HPTA, to quickly restore natural testosterone production. So it is more typically taken during PCT.
My question is why would you take both together? Wouldn't the Nolva, by competing for the same receptors with the Clomid, inhibit recovery post-cycle? Is there some additional benefit to a slower recovery, or a synergistic effect?
Just wondering . . .
T