The esters/blood concentration (educational) thread suggests:
<quote> The best gains from AAS come from the most stable blood concentrations. Look at dbol. It is TREMENDOUSLY more effective if taken all throughout the day rather than once or twice a day. Same with injectable AAS-- You will grow more with a weekly dose of enanthate over a weekly dose of propionate-- Why? More stable blood concentrations. </quote>
The only published evidence I was able to locate on point suggests exactly the opposite (abstract below).
Can anybody relate experience with taking dbol throughout the day (eg, every 4 hours) vs once or twice. Particularly since at typical dosing (say 30 mg a day) this would mean roughly 10 mg peak, which probably translates to more like 5 mg peak concentration in the blood after first pass. Has anybody experienced these "tremendously" greater gains?
Testosterone in a cyclodextrin-containing formulation: behavioral and
physiological effects of episode-like pulses in rats.
Taylor GT, Weiss J, Pitha J
University of Missouri, St. Louis 63121.
Testosterone, administered in the form of an inclusion complex with
2-hydroxypropyl-beta-cyclodextrin by subcutaneous
injection, enters the circulation in a manner markedly similar to the natural
episodic release by the testes. The effects of a
regimen of once-a-day administration of complexed testosterone to adult
(castrated or intact) rats and to senescent (intact) rats
were investigated. Although this procedure left the castrated animals with
concentrations of circulatory hormone far below
physiological levels for much of the day, a significant improvement in
androgen-sensitive behavior and physiology was obtained.
<b>Furthermore, the testosterone effects were more pronounced when high doses
were used periodically rather than when the
same total amount of testosterone was equally divided among doses. </b>The same
supplementation to intact rats intensified
androgen-sensitive behavior and physiology over normal levels. In senescent
rats uniform pulses of the testosterone complex
also improved behavior and physiology. Specifically, spermatogenesis was
stimulated and, notably, the treatment increased
muscle weight without substantial enlargement of the prostate. Since the
testosterone-cyclodextrin complex also can be
effectively administered as a sublingual tablet, the data suggest that similar
regimens may be recommended for elderly men
suffering from decreases in muscle mass.