Dnp Longterm Effects

[HURRICANEl87]

I read on here people debating if DNP has any longterm effects.Well here is an intertesting article i found on another site. Not sure how true or un- true it is !

I just wanted to caution you against the further use of DNP. You must know that DNP causes very strong oxidative burst in the mitochondria. It is comparable with spraying oil into burning fire. All the free oxygen radicals will unevitably cause cumulative damage to your mitochondria and mitochondrial DNA. Mutations in the latter are supposed to be critical for accelerated aging processes. And DNP acts in ALL cells of your body: muscles, brain, connective tissue, skin, etc. So you can be assured that every single DNP-dose will accelerate damage and aging processes throughout your whole body. And even all the antioxidants you are taking will not prevent this. CoQ10 are hardly entering the mitochondria at all. And all the other things like vit. c or vit. e, grape seed etc. have only marginal effects. They can't even completely blunt the deleterious effects from "normal" oxidative damage, let alone a "super-oxidative-burst" that is coming like a vulcano-eruption.
For your own health it would be very advisable to optimize diet and training routines; this alone can and will give you the desired results, assumed you bring up the necessary patience and discipline.

It's your own decision, how you are going to proceed, I justed wanted to shed some light on the "dark side" of DNP that is much much more than just hyperthermia, water intake and the like.

[SwoleCat]

DNP to me always meant = Do Not Participate

Better to adopt a healthy lifestyle consisting of a sterling dietary protocol, weight training, cardio and consistency. Making it a lifestyle is a far better choice rather than searching for a quick fix. Unfortunately, many look for a quick way out and then rebound more than Dennis Rodman.

~SC~

[BajanBastard]

Novel neuroprotective, neuritogenic and anti-amyloidogenic properties of 2,4-dinitrophenol: The gentle face of Janus.

De Felice FG, Ferreira ST.

Instituto de Bioquimica Medica, Programa de Bioquimica e Biofisica Celular, Universidade Federal do Rio de Janeiro, Brazil.

In Roman mythology, Janus was the god of gates, doors, beginnings and endings. He was usually depicted with two faces looking in opposite directions. Janus was frequently used to symbolize change and transitions, such as the progression from past to future or from one viewpoint to another. 2,4-dinitrophenol (DNP) and other nitrophenols have long been known to be toxic at high concentrations (the 'bad' face of DNP), an effect that appears essentially related to interference with cellular energy metabolism due to uncoupling of mitochondrial oxidative phosphorylation. Five years ago, however, we published the first report showing that low concentrations of DNP protect neurons against the toxicity of the amyloid-beta peptide (De Felice et al. (2001) FASEB J. 15:1297 - 1299]. Since then, other studies have provided evidence of beneficial actions of DNP (at low concentrations), including neuroprotection against different types of insult, blockade of amyloid aggregation, stimulation of neurite outgrowth and neuronal differentiation, and even extension of lifespan in certain organisms. Some of these effects appear to be due to mild mitochondrial uncoupling and prevention of cellular oxidative stress, whereas other actions are related to activation of additional intracellular signaling pathways. Thus, a novel and 'gentle' face of DNP is emerging from such studies. In this review, we discuss both toxic and beneficial actions of DNP. The evidence available so far suggests that DNP and other compounds with similar biological activities may be of significant interest to the development of novel therapeutic approaches for neurodegenerative diseases and other neurological disorders.iubmbLife, 58: 185-191, 2006.

PMID: 16754295 [PubMed - in process]

[*Narkissos*]

Novel neuroprotective, neuritogenic and anti-amyloidogenic properties of 2,4-dinitrophenol: The gentle face of Janus.

De Felice FG, Ferreira ST.

Instituto de Bioquimica Medica, Programa de Bioquimica e Biofisica Celular, Universidade Federal do Rio de Janeiro, Brazil.

In Roman mythology, Janus was the god of gates, doors, beginnings and endings. He was usually depicted with two faces looking in opposite directions. Janus was frequently used to symbolize change and transitions, such as the progression from past to future or from one viewpoint to another. 2,4-dinitrophenol (DNP) and other nitrophenols have long been known to be toxic at high concentrations (the 'bad' face of DNP), an effect that appears essentially related to interference with cellular energy metabolism due to uncoupling of mitochondrial oxidative phosphorylation. Five years ago, however, we published the first report showing that low concentrations of DNP protect neurons against the toxicity of the amyloid-beta peptide (De Felice et al. (2001) FASEB J. 15:1297 - 1299]. Since then, other studies have provided evidence of beneficial actions of DNP (at low concentrations), including neuroprotection against different types of insult, blockade of amyloid aggregation, stimulation of neurite outgrowth and neuronal differentiation, and even extension of lifespan in certain organisms. Some of these effects appear to be due to mild mitochondrial uncoupling and prevention of cellular oxidative stress, whereas other actions are related to activation of additional intracellular signaling pathways. Thus, a novel and 'gentle' face of DNP is emerging from such studies. In this review, we discuss both toxic and beneficial actions of DNP. The evidence available so far suggests that DNP and other compounds with similar biological activities may be of significant interest to the development of novel therapeutic approaches for neurodegenerative diseases and other neurological disorders.iubmbLife, 58: 185-191, 2006.

PMID: 16754295 [PubMed - in process]

An aptly named article.

[NCNPC29]

To me the rewards definitely dont' out weigh the risks. DNP is dangerous shit and I dont' think there is enough solid information out there to really know the long term effects. Hell the short term ones can cook you like a microwave! I'll stick to clean eating and busting my ass with cardio