BW: E2 in check but still gyno?

[grilla]

I had BW run last week on the day I was due a sq pin of 50mg test cyp. Pinning 50mg test cyp sq 2x/wk, 250iu hcg 2x/wk.

I ran bw because I definitely have gyno coming on...lumps under both nips, tender to touch, some itch, etc.

E2 is good...so why the gyno?!

Total test: 808 348-1197
Free Test: 37.81 5-21
IGF-1: 348 101-267
Estradiol, sensitive: 21 3-70

RBC: 5.46 4.14-5.8
Hematocrit: 48.4 37.5-51
TSH: 1.01 0.450-4.5
T4: 9.1 4.5-12.0
T3 Uptake: 34 24-39
Free T4 Index: 3.1 1.2-4.9

grilla

[Vettester]

Unfortunately, the symptoms of gyno don't just disappear because your E2 has been normalized.

Beyond a surgical approach, the only thing that might knock it will be letro, which will for sure crash your E2. What I suggest for the moment is to read this thread: http://forums.steroid.com/showthread...now-about-GYNO.

Review your options carefully.

[grilla]

Vette-

It has been in range since I started TRT; I don't use an AI.

grilla

[Vettester]

I would consult a physician to have this evaluated.

[grilla]

I'm going to get prolactin run tomorrow.

Can prolactin be elevated enough to cause gyno while estradiol, sensitive is 21 on a 3-70 range?

grilla

[bass]

I'm going to get prolactin run tomorrow.

Can prolactin be elevated enough to cause gyno while estradiol, sensitive is 21 on a 3-70 range?

grilla

yes it could! anything comes out of the nipples, like clear or milky substance?

[kelkel]

Grilla I responded in the other older thread. Didn't see this one...

[HRTstudent]

Interesting, do you have other e2 tests showing your e2 has historically been at this level?

I do notice that your IGF1 is very high. That is a very important chemical in breast growth. So it could possibly be in part responsible.

But I have also heard that for some people the only answer for breast growth control is tamoxifen. Unfortunately, that is not a drug I would want to be on indefinitely.

If I was in your shoes, I would lower the dose slightly. Looking at your numbers, it probably wouldn't hurt to try.

[grilla]

HRT: When I started TRT a couple months ago, E2 was 16, a month ago it was 26, and last week 21 all tests labcorp estradiol, sensitive with a 3-70 range.

I don't think tamox will help in this case because it acts by blocking estrogen at the chest receptors...and estrogen doesn't seem to be the problem...though I suppose
20s could be too high for me?

I am on a fairly moderate dose...any idea why IGF-1 would be so high?

Bass: Fortunately, I have not started lactating...yet.

grilla

[HRTstudent]

HRT: When I started TRT a couple months ago, E2 was 16, a month ago it was 26, and last week 21 all tests labcorp estradiol, sensitive with a 3-70 range.

I don't think tamox will help in this case because it acts by blocking estrogen at the chest receptors...and estrogen doesn't seem to be the problem...though I suppose
20s could be too high for me?

I am on a fairly moderate dose...any idea why IGF-1 would be so high?

Bass: Fortunately, I have not started lactating...yet.

grilla

You are right about tamoxifen, but the reality is is that you have that estradiol acting in your breast tissue. Estradiol and IGF1 are both critical to breast growth. Not only does tamoxifen help block those breast messages from cascading, but it also can lower IGF1. That's usually not seen as optimal but it is good for stopping breast growth.

[Vettester]

Have you ran any Nor 19 compounds with your TRT? Possibly deca? Run the lab and let's see.

If it is elevated for no particular reason, it might be good to consider an MRI just to be safe.

I use cabergoline to control the prolactin elevation when taking deca. Let us know what you find out.

[grilla]

No Nor compounds...only test cyp and hcg.