Sulfasalazine(what do we know about it)

[RajaSultan]

Does it effect Testosterone in anyway? I heard it decrease fertility but fertility goes back to normal after you stop it, people have used it to treat Alopecia Areta
Raises Estrogen??

anyone here ever had to use it? it was made for the treatment of Arthritis.


Because of its immunomodulatory and immunosuppressive actions, sulfasalazine has shown good hair regrowth in the treatment of alopecia areata. The drug is administered orally usually as enteric coated tablets to minimize the gastrointestinal side effects. The treatment is started at a lower dose, usually in the range of 500 mg twice daily and then the dose is gradually increased to 1 g three times a dayAdverse effects include gastrointestinal distress, liver toxicity and haemotological side effects. Sulfasalazine helps in alopecia areata because it causes inhibition of T cell proliferation, and natural killer cell activity and also inhibits antibody production. It also inhibits the secretion of interleukin (IL)-2, IL-1, TNF- and IFN-gamma and even IL-667.

A number of clinical studies have documented a positive effect of sulfasalazine in alopecia areata. In one clinical study, 23% patients showed a really good response with satisfactory hair growth after sulfasalazine therapyOther studies have also shown a beneficial effect of this treatment option in resistant cases of alopecia areata

[Hoggage_54]

[austinite]

[lovbyts]

So are you going to use it for arthritis or for hair growth?

I dont know that gastrointestinal distress, liver toxicity and haemotological, inhibition of T cell proliferation, and natural killer cell activity and also inhibits antibody production side effects are good trade off's. I'm sure not everyone get this but?

From what I found I would say Yes it effects testosterone.
"Fertility parameters of 10 men with chronic inflammatory bowel disease under treatment with sulfasalazine for at least 5 years were compared to those of 19 control subjects. Seminal parameters examined included ejaculate volume, sperm number and concentration, sperm motility index, sperm viability, pH, zinc concentration, prostaglandins E and F2-alpha, prolactin and 7 classes of sperm morphology. In addition, plasma concentrations of follicle-stimulating hormone, luteinizing hormone, testosterone and prolactin were noted. The data indicate that sulfasalazine therapy reduces semen quality and that this effect can be reversed upon removal from therapy. This reversal is independent of seminal prostaglandin concentrations."

[RajaSultan]

So are you going to use it for arthritis or for hair growth?

I dont know that gastrointestinal distress, liver toxicity and haemotological, inhibition of T cell proliferation, and natural killer cell activity and also inhibits antibody production side effects are good trade off's. I'm sure not everyone get this but?

From what I found I would say Yes it effects testosterone.
"Fertility parameters of 10 men with chronic inflammatory bowel disease under treatment with sulfasalazine for at least 5 years were compared to those of 19 control subjects. Seminal parameters examined included ejaculate volume, sperm number and concentration, sperm motility index, sperm viability, pH, zinc concentration, prostaglandins E and F2-alpha, prolactin and 7 classes of sperm morphology. In addition, plasma concentrations of follicle-stimulating hormone, luteinizing hormone, testosterone and prolactin were noted. The data indicate that sulfasalazine therapy reduces semen quality and that this effect can be reversed upon removal from therapy. This reversal is independent of seminal prostaglandin concentrations."

Hair growth,
Let's say i am on a Test E(will be adding jintropin, HCG my AI would be Aromaisin) Cycle while i am taking Sulfasalazine, will it effect my gains on my cycle in any way?
Should i take Milk Thistle supplements to avoid liver problems also?
any other supplements i should add, I don't know what i should take to control gas while on it, It wouldn't be nice that i am farting while i am working out at the gym.

[Indymuscleguy]

I suffered from Ulcerative Colitis for about 7 years. I had to have my colon removed and had a J-Pouch created (internally) out of my small intestine. During the 7 years, I used that medication (Uhhh humm...cough...cough) in a suppository form. It worked great but had no idea it affected my natty test levels. Learn something new everyday.

So are you going to use it for arthritis or for hair growth?

I dont know that gastrointestinal distress, liver toxicity and haemotological, inhibition of T cell proliferation, and natural killer cell activity and also inhibits antibody production side effects are good trade off's. I'm sure not everyone get this but?

From what I found I would say Yes it effects testosterone.
"Fertility parameters of 10 men with chronic inflammatory bowel disease under treatment with sulfasalazine for at least 5 years were compared to those of 19 control subjects. Seminal parameters examined included ejaculate volume, sperm number and concentration, sperm motility index, sperm viability, pH, zinc concentration, prostaglandins E and F2-alpha, prolactin and 7 classes of sperm morphology. In addition, plasma concentrations of follicle-stimulating hormone, luteinizing hormone, testosterone and prolactin were noted. The data indicate that sulfasalazine therapy reduces semen quality and that this effect can be reversed upon removal from therapy. This reversal is independent of seminal prostaglandin concentrations."

[lovbyts]

Jintropin are going to be fake
Milk thistle is OK but weak for liver protection. Use NAC & Liv52
Gas is usually from to much protein.
I dont think it will effect your test while on cycle but it probably will effect natural test levels.

[RajaSultan]

Jintropin are going to be fake
Milk thistle is OK but weak for liver protection. Use NAC & Liv52
Gas is usually from to much protein.
I dont think it will effect your test while on cycle but it probably will effect natural test levels.

I'll take my chances with Jintropin, Jintropin is used in hospitals over here so yeah will take my chances.
I usually get gas from carbs so idk about too much protein.
Thanks, I couldn't care less about natty test levels as they are naturally low. 290ng/dl mid day.

[Bonaparte]

It can help treat Alopecia Areta (an autoimmune condition) because it lowers your immune system.
Hairloss from steroids is androgenic alopecia, which sulfasalazine won't treat.
You need a DHT blocker for that.

But if you suffer from ulcerative colitis or rheumatoid arthritis, then sulfasalazine would be a great choice.

[RajaSultan]

It can help treat Alopecia Areta (an autoimmune condition) because it lowers your immune system.
Hairloss from steroids is androgenic alopecia, which sulfasalazine won't treat.
You need a DHT blocker for that.

But if you suffer from ulcerative colitis or rheumatoid arthritis, then sulfasalazine would be a great choice.

I know about DHT hairloss, Would use Fina to avoid DHT loss while cycling(fina side effects = over hyped)

also when Sulfasalazine lowers your immune system, does it make us more vulnerable to getting diseases? Flu's cold's etc etc.

[Bonaparte]

I know about DHT hairloss, Would use Fina to avoid DHT loss while cycling(fina side effects = over hyped)

also when Sulfasalazine lowers your immune system, does it make us more vulnerable to getting diseases? Flu's cold's etc etc.

Have you use finasteride? I have, and it sucked.

And yeah, weakening your immune system would make you more prone to infections.

[RajaSultan]

Have you use finasteride? I have, and it sucked.

And yeah, weakening your immune system would make you more prone to infections.

How much Fina were you running?

[Bonaparte]

How much Fina were you running?

Like 0.2mg daily. The stuff is potent, and losing 80% of your DHT is very noticeable.

[frank13]

It can help treat Alopecia Areta (an autoimmune condition) because it lowers your immune system.
Hairloss from steroids is androgenic alopecia, which sulfasalazine won't treat.
You need a DHT blocker for that.

But if you suffer from ulcerative colitis or rheumatoid arthritis, then sulfasalazine would be a great choice.

What dht blocker would u recommend???

[RajaSultan]

What dht blocker would u recommend???

Fina is the most researched so i will say go with fina, the limp dick sides only start 6-7 months for most people running 0.5mg - 1mg they go away when stopped.
People say Duta is much more effective but it hasn't been researched enough so a No for duta since most people reported side effects of limp dick even after stopping duta.

[Bonaparte]

What dht blocker would u recommend???

Any topical ones (like spironolactone).

[frank13]

Any topical ones (like spironolactone).

I'm guessing that would be prescription only?

[Bonaparte]

I'm guessing that would be prescription only?

Yes, as is just about anything that works.

[tarmyg]

My wife took it for ulcerative colitis and she felt like complete shit. Taking that stuff because you lost hair sounds to me like the dumbest thing I have ever heard. Lowering your immune system to MAYBE get some hair back!?!

[Hoggage_54]